Protein Alignment RunxB and RUNX1

DIOPT Version :9

• Sequence 1: NP_001259745.1
• Gene: RunxB / 33051
• FlyBaseID: FBgn0259162
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: NP_001745.2
• Gene: RUNX1 / 861
• HGNCID: 10471
• Length: 480
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 167/489 - (34%)
• Similarity: 224/489 - (45%)
• Gaps: 138/489 - (28%)

  Fly   108 ERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDEN 172
            :|::..:||:||||||:|.||:.:|:.||||||.||||||||||:|||:|.|||:||:.||||||
Human    75 DRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDEN 139

  Fly   173 FCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIVISTNPIQIATYTKAIKVTVDGPREPR 237
            :..||||.||.||||||:||||||||||||||||||||.:.|||.|:|||.:|||:|||||||||
Human   140 YSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 204

  Fly   238 SKVRHQGFHPFAFGPQRFGPDPLMAGLPFKLPGFAHHLVGMHSHLHAPDWRAHMALGGRPAAFTA 302
               ||:         |:.........|     .|:..|..:...              |..|...
Human   205 ---RHR---------QKLDDQTKPGSL-----SFSERLSELEQL--------------RRTAMRV 238

  Fly   303 APFFGHHAAAFPT--ASGLRGLSGDSQQHQQQQQQHQLAT------------VGAAHSTTSPEGS 353
            :|   ||.|..|.  ||.....:.:.|...|.|...|:..            :|   |..||...
Human   239 SP---HHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLG---SIASPSVH 297

  Fly   354 PTTTTTSG-----TQLSAFVQPPMTSSP-----------PPVTSLQHDNNNNNSNNNNSSSHIDA 402
            |.|..:.|     |.|||.:...::::|           |.:.|:           ::...|...
Human   298 PATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSI-----------SDPRMHYPG 351

  Fly   403 GFESDSISVTGSPRKSLGSPLTHDEEEAEAEAEAEAEAEAEAEEAEVG-GLSRNGGGIQ-----G 461
            .|       |.||     :|:|                      :.:| |:|..|...:     .
Human   352 AF-------TYSP-----TPVT----------------------SGIGIGMSAMGSATRYHTYLP 382

  Fly   462 PLHSESSPGSGGAFTALIQRSGKNPT-ELFGGFAAAGGNHFAPSGHSFNPA--------LAAQLF 517
            |.:..||...||.|.|      .:|: .|:.| |:||...|:..|...:|.        .:....
Human   383 PPYPGSSQAQGGPFQA------SSPSYHLYYG-ASAGSYQFSMVGGERSPPRILPPCTNASTGSA 440

  Fly   518 LQSPLLPQSSQWLYTQLYGSYSDLPWLRNAAAAA 551
            |.:|.||..|.  ..:..||:|:.|  .|.|.:|
Human   441 LLNPSLPNQSD--VVEAEGSHSNSP--TNMAPSA 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RunxB	NP_001259745.1	Runt	118..239	CDD:279225	92/120 (77%)
RUNX1	NP_001745.2	Runt	81..207	CDD:395684	95/128 (74%)
		RunxI	389..480	CDD:400691	26/93 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2778
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	1	1.000	-	-		mtm8468
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.010