Protein Alignment RunxB and runx2a

DIOPT Version :10

• Sequence 1: NP_001259745.1
• Gene: RunxB / 33051
• FlyBaseID: FBgn0259162
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: NP_998023.1
• Gene: runx2a / 405784
• ZFINID: ZDB-GENE-040629-3
• Length: 467
• Species: Danio rerio
• Alignment Length: 394
• Identity: 142/394 - (36%)
• Similarity: 197/394 - (50%)
• Gaps: 65/394 - (16%)

  Fly    88 NNVKTKPVDTSPYLTPENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVL 152
            ::.:.:|....|.|.|.:  .||:..::|:||.|||:|.||:.:|:.||:|||.|||||:||||:
Zfish    42 SDAQPEPNAVVPRLRPHD--NRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVV 104

  Fly   153 ALGEVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIVISTNPI 217
            |||:|.|||:||:.||||||:..||||.:||||||||:||||||||||||||||||||.:.|||.
Zfish   105 ALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPP 169

  Fly   218 QIATYTKAIKVTVDGPREPRSKVRHQGF-----HPFAFGP-----------------QRFGPDPL 260
            |:|||.:|||||||||||||   ||:..     .|..|..                 |...|.|.
Zfish   170 QVATYHRAIKVTVDGPREPR---RHRQKLEDPPKPPLFSERLSELERLRQTTMRVAVQTQSPRPS 231

  Fly   261 MAGLPFKL-PGFAHHLVGMHSHLHAPDWR------AHMALGGRPAAFTAAPFFGHHAAAFPTASG 318
            :...|... |.....:........:|.|.      .:::....|:..:..|.....|...||.|.
Zfish   232 LNATPNSFNPQGQTQISDPRQAQSSPPWSYEQPYPPYLSQMTSPSIHSTTPLSSTRATGLPTISD 296

  Fly   319 L-RGLSGDSQ----QHQQQQQQHQLATVGAAHSTTSPEGS---PTTTTTSGTQLSAFVQPPMTSS 375
            : |.|||.|:    ....:|.:.|..::.:...:..|...   |.|.|.:.|.:::.:...|:::
Zfish   297 VPRRLSGTSELSPFSADPRQFERQFPSLSSLTDSRFPSPRMHYPATFTYTPTPVTSGMSLGMSTT 361

  Fly   376 -------PPPVTSLQHDNNNNNSNNNNSSSHIDAGFESDSIS---VTGSPRK-----------SL 419
                   |||...  ...|.:.....:|:.::..|..|.|..   |.|..|.           |.
Zfish   362 THYHTYLPPPYPG--STQNQSGPFQTSSTPYLYYGASSGSYQFPMVPGGDRSPSRMLPPCTSAST 424

  Fly   420 GSPL 423
            ||.|
Zfish   425 GSTL 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RunxB	NP_001259745.1	Runt	115..239	CDD:459963	91/123 (74%)
runx2a	NP_998023.1	Runt	63..191	CDD:459963	91/130 (70%)
		PHA03247	<222..458	CDD:223021	41/209 (20%)
		RunxI	376..467	CDD:430037	12/53 (23%)