Protein Alignment RunxB and Runx1

DIOPT Version :9

• Sequence 1: NP_001259745.1
• Gene: RunxB / 33051
• FlyBaseID: FBgn0259162
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: NP_001104491.1
• Gene: Runx1 / 12394
• MGIID: 99852
• Length: 465
• Species: Mus musculus
• Alignment Length: 461
• Identity: 163/461 - (35%)
• Similarity: 221/461 - (47%)
• Gaps: 99/461 - (21%)

  Fly   108 ERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDEN 172
            :|::..:||:||||||:|.||:.:|:.||||||.||||||||||:|||:|.|||:||:.||||||
Mouse    62 DRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDEN 126

  Fly   173 FCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIVISTNPIQIATYTKAIKVTVDGPREPR 237
            :..||||.||.||||||:||||||||||||||||||||.:.|||.|:|||.:|||:|||||||||
Mouse   127 YSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 191

  Fly   238 SKVRHQGFHPFAFGPQRFGPDPLMAGLPFKLPGFAHHLVGMHSHLHAPDWRAHMALGGRPAAFTA 302
               ||:         |:.........|     .|:..|..:...              |..|...
Mouse   192 ---RHR---------QKLDDQTKPGSL-----SFSERLSELEQL--------------RRTAMRV 225

  Fly   303 APFFGHHAAAFPTASGLRGLSGDSQQHQQQQQQHQLATVGAAHSTTSPEGSPTTTTTS----GTQ 363
            :|   ||.|  ||.:....|:..:..:.|.|.|.|    .|.....||   |.:...|    |:.
Mouse   226 SP---HHPA--PTPNPRASLNHSTAFNPQPQSQMQ----DARQIQPSP---PWSYDQSYQYLGSI 278

  Fly   364 LSAFVQPPMTSSP---PPVTSLQHDNNNNNSNNNNSSSHIDAGFESDSISVTGSPRK-----SLG 420
            .|:.|.|....||   ..:|||..:.::..|.             :..::..|.||:     |:.
Mouse   279 TSSSVHPATPISPGRASGMTSLSAELSSRLST-------------APDLTAFGDPRQFPTLPSIS 330

  Fly   421 SPLTHDEEEAEAEAEAEAEAEAEAEEAEVG-GLSRNGGGIQ-----GPLHSESSPGSGGAFTALI 479
            .|..|         ...|...:....:.:| |:|......:     .|.:..||....|.|
Mouse   331 DPRMH---------YPGAFTYSPPVTSGIGIGMSAMSSASRYHTYLPPPYPGSSQAQAGPF---- 382

  Fly   480 QRSGKNPTELFGGFAAAGGNHFAPSGHSFNPA--------LAAQLFLQSPLLPQSSQWLYTQLYG 536
             ::|.....|:.| |:||...|:..|...:|.        .:....|.:|.||..|..:.|:  |
Mouse   383 -QTGSPSYHLYYG-ASAGSYQFSMVGGERSPPRILPPCTNASTGAALLNPSLPSQSDVVETE--G 443

  Fly   537 SYSDLP 542
            |:|:.|
Mouse   444 SHSNSP 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RunxB	NP_001259745.1	Runt	118..239	CDD:279225	92/120 (77%)
Runx1	NP_001104491.1	Runt	72..193	CDD:307137	92/123 (75%)
		RunxI	375..465	CDD:312115	22/83 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2765
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	1	1.000	-	-		mtm8706
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.010