DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSPA1L and Hsc70-4

DIOPT Version :9

Sequence 1:NP_005518.3 Gene:HSPA1L / 3305 HGNCID:5234 Length:641 Species:Homo sapiens
Sequence 2:NP_001262586.1 Gene:Hsc70-4 / 41840 FlyBaseID:FBgn0266599 Length:651 Species:Drosophila melanogaster


Alignment Length:650 Identity:517/650 - (79%)
Similarity:576/650 - (88%) Gaps:12/650 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     4 AKGIAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNT 68
            :|..|:||||||||||||||||||||||||||||||||||||||||||||||||||||||||..|
  Fly     2 SKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQT 66

Human    69 VFDAKRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEEISSMVLTKLKETA 133
            :|||||||||||:|..||:|||.|||:|::..||||:.|:||.|.|.|:|||||||||||:||||
  Fly    67 IFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETA 131

Human   134 EAFLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGERHVL 198
            ||:||..||||||||||||||||||||||||.||||||||||||||||||||||||...|||:||
  Fly   132 EAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNVL 196

Human   199 IFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVR 263
            ||||||||||||||:|||||||||:|||||||||||||||||:|||:|||||||||::.||||:|
  Fly   197 IFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALR 261

Human   264 RLRTACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKM 328
            |||||||||||||||||||::|||||:||.||||||||||||||.|||||.|::||||||||||:
  Fly   262 RLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKL 326

Human   329 DKAKIHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDL 393
            ||:.||||||||||||||||||||||.|||::||||||||||||||||||||||.||||::||||
  Fly   327 DKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDL 391

Human   394 LLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLL 458
            |||||.|||||:|||||||:.|||||:||||||||.|||||||||||||||||||||||||||||
  Fly   392 LLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLL 456

Human   459 GRFDLTGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKVNKITITNDKGRLSKEEIERMVLD 523
            |:|:|:||||||||||||||||||||||||||||.::||.|.|||||||||||||||:|||||.:
  Fly   457 GKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVNE 521

Human   524 AEKYKAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISESDKNKILDKCNELLSWLEVNQL 588
            ||||:.|||.|:|.|||||.||||.||||:.:.::.||.|||:||:..|||||||.:.||:.|||
  Fly   522 AEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDANQL 586

Human   589 AEKDEFDHKRKELEQMCNPIITKLYQGGCTGP------------ACGTGYVPGRPATGPTIEEVD 641
            |:|:|::|::||||.:|||||||||||....|            |.|.....|....||||||||
  Fly   587 ADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGGMPGAAGAAGAAGAGGAGPTIEEVD 651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HSPA1LNP_005518.3 Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 3..388 327/383 (85%)
HSP70 4..641 CDD:331774 515/648 (79%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 396..511 100/114 (88%)
Hsc70-4NP_001262586.1 PTZ00009 1..612 CDD:240227 502/609 (82%)
HSPA1-2_6-8-like_NBD 6..381 CDD:212675 322/374 (86%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53894
OrthoDB 1 1.010 - - D180577at33208
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 1 1.000 - - otm41703
orthoMCL 1 0.900 - - OOG6_100083
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X148
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.730

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