Protein Alignment HSPA1L and Hsc70-2

DIOPT Version :9

• Sequence 1: NP_005518.3
• Gene: HSPA1L / 3305
• HGNCID: 5234
• Length: 641
• Species: Homo sapiens
• Sequence 2: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Alignment Length: 635
• Identity: 456/635 - (71%)
• Similarity: 536/635 - (84%)
• Gaps: 9/635 - (1%)

Human     8 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDA 72
            |||||||||||||||:|:.||||||||||||||||||||.:|||||||.||||||||.:||||||
  Fly     6 AIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDA 70

Human    73 KRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEEISSMVLTKLKETAEAFL 137
            ||||||||:|..:|.|:|||||:||||.||||:.|.:|||.|.|.|||||||||||::|.||.:|
  Fly    71 KRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYL 135

Human   138 GHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGERHVLIFDL 202
            |..|.:||:||||||||||||||||||.|||||||||||||||||:||||||..:|||:||||||
  Fly   136 GGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 200

Human   203 GGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLR 266
            ||||||||:|:||:| :||||||||||||||||||||||:||.||||||||.||..|.||:||||
  Fly   201 GGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRRLR 265

Human   267 TACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKMDKA 331
            ||||||||||||||:|:||||:|:||||||:.|:|||||||..||||.|::|||:||.||||||.
  Fly   266 TACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKMDKK 330

Human   332 KIHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLL 396
            .|||:|||||||||||:|:||||.|.|:.||.|||||||||||||||||||.|..|.::|||||:
  Fly   331 AIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLLV 395

Human   397 DVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRF 461
            ||||||||:||||||||.|::||:.||.||.||||||||||..|.||||||||||||||||||.|
  Fly   396 DVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNNLLGTF 460

Human   462 DLTGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKVNKITITNDKGRLSKEEIERMVLDAEK 526
            :||||||||||||||||.||::|:|||||.|.|.||||..||||:||||||||.||:||:.:|||
  Fly   461 NLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRMLSEAEK 525

Human   527 YKAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISESDKNKILDKCNELLSWLEVNQLAEK 591
            ||.||:.|||::.:||.||:|.:..:..| |:...|.:||::::|:.|||:...|||:.|.||||
  Fly   526 YKVEDDRQRERVQSKNNLEAYIYACRQAV-DDAPSGVLSETERSKVRDKCSSEASWLDKNSLAEK 589

Human   592 DEFDHKRKELEQMCNPIITKLYQGGCTGPACGTGYVPGRPATGPTIEEVD 641
            :||:...||.:::|.||::|::.|.....:.|.|       :.||:||||
  Fly   590 EEFESHLKECQRICTPIMSKIHGGKKGKSSMGKG-------SHPTVEEVD 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA1L	NP_005518.3	Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		302/380 (79%)
		HSP70	4..641	CDD:331774	454/633 (72%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		90/114 (79%)
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	454/633 (72%)
		HSPA1-2_6-8-like_NBD	6..382	CDD:212675	300/375 (80%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.830