Protein Alignment HSPA1L and Hsc70Cb

DIOPT Version :9

• Sequence 1: NP_005518.3
• Gene: HSPA1L / 3305
• HGNCID: 5234
• Length: 641
• Species: Homo sapiens
• Sequence 2: NP_001189103.1
• Gene: Hsc70Cb / 39557
• FlyBaseID: FBgn0026418
• Length: 836
• Species: Drosophila melanogaster
• Alignment Length: 710
• Identity: 212/710 - (29%)
• Similarity: 344/710 - (48%)
• Gaps: 116/710 - (16%)

Human     9 IGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDAK 73
            ||||.|.....|...:.|.:|.:|||...|.|||:|||...:|:||.|||||...|.:|||...|
  Fly     4 IGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFK 68

Human    74 RLIGRKFNDPVVQADMKLWPFQVINEG-GKPKVLVSYKGENKAFYPEEISSMVLTKLKETAEAFL 137
            ||:|||||||.||.::...|.:|...| |...:.|:|.||::.|.||::::|:.||||||:.|.:
  Fly    69 RLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAAAM 133

Human   138 GHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGE---RHVLI 199
            ...|.:.||..|.:|.:::|:|..||..||||||||::||.||.|:|||..|....|   |:|:.
  Fly   134 QTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPRNVIF 198

Human   200 FDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRR 264
            .|.|..:...|......|..::.|:..| .:||.|.|..|..:|.:||:.::|.:...|.||..|
  Fly   199 VDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNARANLR 262

Human   265 LRTACERAKRTLS-SSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKM 328
            |.|..|:.|:.:| :||:..|.|:...:.||..:|:.|::.|||||.:.:...:..::.|.::|:
  Fly   263 LLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAESKL 327

Human   329 DKAKIHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDL 393
            ....||.:.:||||:|||.|::|::..|| :..:.::|.||||:.|||:|.||:  ..:.:|::.
  Fly   328 QLDDIHSVEIVGGSSRIPSVKQLIEQVFN-KPASTTLNQDEAVSRGAALQCAIM--SPAVRVREF 389

Human   394 LLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTY---------SDNQPGVL-IQVYEGE 448
            .:.|:...:        |........|..| .:.:||..|         :.|:.|.. :.:..|:
  Fly   390 GVTDIQNYA--------VKVLWDSEGSAAP-GEIEIFPQYHASPFSRLLTINRKGPFNVSIVYGQ 445

Human   449 RAMTKDNNLLGRFDLTGIPPAPRGVPQ-IEVTFDIDANGIL------------------------ 488
            :....|.. :|.:.:..:.|..||..| :::...|:.|||:
  Fly   446 QVPYPDQT-IGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAA 509

Human   489 -----------------------------NVTATDKSTG-----------------------KVN 501
                                         |.|:|..|.|                       |..
  Fly   510 SEEKPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKAT 574

Human   502 KITITNDKGRLSKEEIERMVLDAEKYKAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISE 566
            ::.:.......|..::........|....|:.:.|:|.||||||.:.::|::.:.....:..:.|
  Fly   575 ELPLECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVE 639

Human   567 SDKNKILDKCNELLSWL-EVNQLAEKDEFDHKRKELEQMCNPIITKL----YQGGCTGPA 621
            :::.||:.:.|:|.:|| |..:..|:|.:..:.:.|.|..:||  ||    |:   .|||
  Fly   640 AEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPI--KLRASDYE---QGPA 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA1L	NP_005518.3	Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		153/383 (40%)
		HSP70	4..641	CDD:331774	212/710 (30%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		26/201 (13%)
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	153/380 (40%)
		HSP70	3..682	CDD:278441	204/691 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156587
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740