Protein Alignment HSPA1L and Hsc70-5

DIOPT Version :9

• Sequence 1: NP_005518.3
• Gene: HSPA1L / 3305
• HGNCID: 5234
• Length: 641
• Species: Homo sapiens
• Sequence 2: NP_001286414.1
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 606
• Identity: 306/606 - (50%)
• Similarity: 409/606 - (67%)
• Gaps: 21/606 - (3%)

Human     5 KGIAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPQNT 68
            ||..||||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..||
  Fly    51 KGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115

Human    69 VFDAKRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEEISSMVLTKLKETA 133
            .:..||||||:|:||.|:.|:....::|:........:.|..|  |.:.|.:|.:.:|.|:||||
  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDG--KVYSPSQIGAFILMKMKETA 178

Human   134 EAFLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGERHVL 198
            ||:|..||.|||:||||||||||||||||||.||||||||:||||||||:|||:||  ..::.:.
  Fly   179 EAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDK--TEDKIIA 241

Human   199 IFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVR 263
            ::||||||||:|||.|..|:||||:|.|||.||||||||.:|:..|.|||:....||.::..|::
  Fly   242 VYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQ 306

Human   264 RLRTACERAKRTLSSSTQANLEIDSLYEGID------FYTSITRARFEELCADLFRGTLEPVEKA 322
            ||:.|.|:||..||||.|.::.:.  |..:|      ....:||::.|.|..||.:.|::|.:||
  Fly   307 RLKEAAEKAKCELSSSQQTDINLP--YLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKA 369

Human   323 LRDAKMDKAKIHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKS 387
            |.||::.|::|.:::||||.||:||||..:|:.| ||..::|:|||||||.|||||..:|.||
  Fly   370 LSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD-- 431

Human   388 EKVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMT 452
              |.|:|||||.|||||:||.|||.|.||.||:|||||::|:|:|.||.|..|.|:|::|||.|.
  Fly   432 --VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMA 494

Human   453 KDNNLLGRFDLTGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKVNKITITNDKGRLSKEEI 517
            .||.|||.|.|.||||||||||||||.||||||||::|:|.||.|||..:|.| ...|.|||:||
  Fly   495 NDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKDEI 558

Human   518 ERMVLDAEKYKAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISESDKNKILDKCNELLSW 582
            |.|:..||:|...|:.:||.|...|..||...:.::.:  |..|.::...:..|:..:..:|.:.
  Fly   559 ENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKM--EEFKSQLPAEECEKLKKEIADLRTL 621

Human   583 LEVNQLAEKDEFDHKRKELEQ 603
            |...:.|:.:|.......|:|
  Fly   622 LANKETADLEEVRKATSSLQQ 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA1L	NP_005518.3	Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		201/389 (52%)
		HSP70	4..641	CDD:331774	306/606 (50%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		74/114 (65%)
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	306/606 (50%)
		HSPA9-like_NBD	51..428	CDD:212683	198/383 (52%)
		Syntaphilin	<566..>642	CDD:291936	17/77 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820