Protein Alignment HSPA1L and Hsc70-3

DIOPT Version :9

• Sequence 1: NP_005518.3
• Gene: HSPA1L / 3305
• HGNCID: 5234
• Length: 641
• Species: Homo sapiens
• Sequence 2: NP_001285139.1
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Alignment Length: 617
• Identity: 384/617 - (62%)
• Similarity: 494/617 - (80%)
• Gaps: 5/617 - (0%)

Human     6 GIAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPQNTV 69
            |..||||||||||||||:::|:|||||||||||.|||||||| |.|||||||||||:..||:|||
  Fly    29 GTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTV 93

Human    70 FDAKRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEEISSMVLTKLKETAE 134
            |||||||||:::|..||.|:|.:||:|:.:..||.:.|......|.|.|||||:|||.|:|||||
  Fly    94 FDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAE 158

Human   135 AFLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGERHVLI 199
            |:||..||:||:||||||||:||||||||||||||.|:||||||||||||||||| .:||::||:
  Fly   159 AYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDK-KEGEKNVLV 222

Human   200 FDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRR 264
            |||||||||||:||||:|:|||.||.|||||||||||.|::.||::.:|:|..|||.::.|||::
  Fly   223 FDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQK 287

Human   265 LRTACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKMD 329
            ||...|:|||.||.|.|..:||:|.:||.||..::|||:||||..||||.||:||:|.|.||.|:
  Fly   288 LRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMN 352

Human   330 KAKIHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLL 394
            |..:|:||||||||||||||:|::|:|.|::.::.|||||||||||||||.:|.|:  :....::
  Fly   353 KKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTDAIV 415

Human   395 LLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLG 459
            ||||.||::|:||.|||||.||.||:.||||::|:|:|.||||..|.||||||||.|||||:|||
  Fly   416 LLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLG 480

Human   460 RFDLTGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKVNKITITNDKGRLSKEEIERMVLDA 524
            :||||||||||||:|||||:|:|||||||.|:|.||.||...||.||||:.||:.|:|:||:.||
  Fly   481 KFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDA 545

Human   525 EKYKAEDEVQREKIAAKNALESYAFNMKSVVSD-EGLKGKISESDKNKILDKCNELLSWLEVNQL 588
            ||:..||:..:|::.::|.|||||:::|:.:.| :.|..|:|:.:|||:....:|.:.|||.|..
  Fly   546 EKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPD 610

Human   589 AEKDEFDHKRKELEQMCNPIITKLYQGGCTGP 620
            |:.:|:..::|:||.:..|:|.|||||....|
  Fly   611 ADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAP 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA1L	NP_005518.3	Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		256/382 (67%)
		HSP70	4..641	CDD:331774	384/617 (62%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		82/114 (72%)
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	253/374 (68%)
		PTZ00009	32..643	CDD:240227	383/614 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730