DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1812 and KBTBD11

DIOPT Version :9

Sequence 1:NP_608397.1 Gene:CG1812 / 33049 FlyBaseID:FBgn0031119 Length:616 Species:Drosophila melanogaster
Sequence 2:NP_055682.1 Gene:KBTBD11 / 9920 HGNCID:29104 Length:623 Species:Homo sapiens


Alignment Length:548 Identity:130/548 - (23%)
Similarity:197/548 - (35%) Gaps:170/548 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 AATPAPAVTP--AATATSAAAKIP------VNPVSPEE----ETLLRGLNKLRNEEKLTDVTLIV 54
            ||:|....:|  .|.....||..|      .:|.||||    ..:..|...:..|   .|:.|.|
Human    85 AASPEELASPEERACPEEPAAPSPEPRVWLEDPASPEEPGEPAPVPPGFGAVYGE---PDLVLEV 146

  Fly    55 EEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKARAMGSIIDYIYTS-MLELNYDN 118
            ...|.:||:.||||.||||.|        .:.:|.:.:.|:...|:..::...|:. |..:..||
Human   147 SGRRLRAHKAVLAARSDYFRA--------RASRDVLRVQGVSLTALRLLLADAYSGRMAGVRPDN 203

  Fly   119 IEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEE--- 180
            :.|::|.|..:|:.....|.|..:|.::.:.||..:...|....:.:|.:.||.:|..|:.|   
Human   204 VAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLEVLR 268

  Fly   181 ----FATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQLNESALGDLLRLIKWQH 241
                |...|.                     ||:||                    |||      
Human   269 EPAVFGRLSG---------------------AERDL--------------------LLR------ 286

  Fly   242 ISYKSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVVSLKDQSLPQGPTNMRGMELC 306
                               ::|        |..:.|:.....|....:..|.||.|:        
Human   287 -------------------RRL--------RAGRAHLLAAALGPAGERAGSRPQSPS-------- 316

  Fly   307 LLKIGGFEWNGLTNVIMCFSPKKMNWYELTAIPH---IDQCNFGTAVLNNKLFIVGGAYDVFLKE 368
                |..:..| ...:.||......|.|||.:|.   ...|  |..||.|.||:.||        
Human   317 ----GDADARG-DAAVYCFHAAAGEWRELTRLPEGAPARGC--GLCVLYNYLFVAGG-------- 366

  Fly   369 YIHPFG-----------FCYCPLRNTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEAL 422
             :.|.|           |||.|..::|..:.|::|.|.:..|.|: ..|||||||          
Human   367 -VAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLAL-DGHLYAVGG---------- 419

  Fly   423 RMISNVERYDIAKNVWTYMPSLQEN--RSQHAGVVVGDKLYISGGVHLANILASMWVFDTKTEVW 485
            ..:.:|||||...:.|..:..|...  ...|.......::|:|||    ::...:..:|.:.:.|
Human   420 ECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG----SLFYRLLKYDPRRDEW 480

  Fly   486 QELASMPTPCCDH-----VLVAVDNRIY 508
            ||     .||...     .:||:|..||
Human   481 QE-----CPCSSSRERSADMVALDGFIY 503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1812NP_608397.1 BTB 38..142 CDD:279045 29/104 (28%)
PHA03098 46..588 CDD:222983 115/492 (23%)
BACK 151..249 CDD:285009 17/104 (16%)
KELCH repeat 344..390 CDD:276965 16/56 (29%)
KELCH repeat 394..444 CDD:276965 16/49 (33%)
Kelch 406..458 CDD:128874 15/53 (28%)
Kelch_1 448..492 CDD:279660 9/43 (21%)
KELCH repeat 448..492 CDD:276965 9/43 (21%)
Kelch_1 494..539 CDD:279660 7/20 (35%)
KELCH repeat 495..539 CDD:276965 6/19 (32%)
KBTBD11NP_055682.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..129 13/43 (30%)
DUF719 54..>136 CDD:283086 14/50 (28%)
BTB 141..226 CDD:197585 28/92 (30%)
BTB 141..225 CDD:279045 27/91 (30%)
Kelch 1 311..359 16/62 (26%)
Kelch_1 348..399 CDD:279660 17/61 (28%)
KELCH repeat 350..398 CDD:276965 16/58 (28%)
Kelch 2 360..412 16/61 (26%)
KELCH repeat 402..442 CDD:276965 16/50 (32%)
Kelch 3 413..455 15/51 (29%)
Kelch 413..449 CDD:128874 14/45 (31%)
Kelch_1 450..484 CDD:279660 9/42 (21%)
Kelch 4 458..500 12/50 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1072
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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