DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1812 and KLHL13

DIOPT Version :9

Sequence 1:NP_608397.1 Gene:CG1812 / 33049 FlyBaseID:FBgn0031119 Length:616 Species:Drosophila melanogaster
Sequence 2:XP_011529711.1 Gene:KLHL13 / 90293 HGNCID:22931 Length:661 Species:Homo sapiens


Alignment Length:607 Identity:168/607 - (27%)
Similarity:275/607 - (45%) Gaps:59/607 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 TSAAAKIPVNPVSPEEETLLRGLNKLRNEEKLTDVTLIV--EEHRFKAHRVVLAASSDYFCAMFA 78
            :|.|....:...:.....:|:|.::||.|..|.||||:.  .:..|..|||::|::||||.|||.
Human    66 SSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFT 130

  Fly    79 DCAMIESRKDEINLYGIKARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLG 143
            . .|.|.....|.|:|:....:..|||:|||:.|.||.||:::.|.||:.:|:..|:|.|.:||.
Human   131 G-GMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 194

  Fly   144 AKIEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVA 208
            :.:.::||:.:..:|:.|.:.::.:....::..:|....:|.:|.::..::|.|:||||......
Human   195 SGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 259

  Fly   209 EQDLVRLVCSFAIEQQLNESALGDLLRLIK---------WQHISY-KSVDELRNMNCSLDKGKQL 263
            |.:|.:..|.:.   :|.|..:....:|:|         .:.|:| ::||.:|..|..::    |
Human   260 ELELFKATCRWL---RLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVN----L 317

  Fly   264 PLPTSYYNRIKQEHMGHLLNGVVSLKDQSLPQGPTNMRGMELCLLKIGGFEWNGL--TNVIMCFS 326
            .|..|.|.             ::......:....|.:|.....|:.:||.....|  :..:..:.
Human   318 LLEASNYQ-------------MMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD 369

  Fly   327 PKKMNWYELTAIPHIDQCNFGTAVLNNKLFIVGGA--YDVFLKEYIHPFGFCYCPLRNTWMTIAP 389
            .|...|..|..: ...:...|.||:.|.|::|||.  ||...|..:... |.:.|..|.||.:|.
Human   370 EKAHEWKSLAPM-DAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTV-FRFDPRYNKWMQVAS 432

  Fly   390 IQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGV 454
            :.:.|..|.|:|: ..:||||||      ..|...:..||.|:...|.|||:..:.|....|||.
Human   433 LNEKRTFFHLSAL-KGYLYAVGG------RNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGT 490

  Fly   455 VVGDKLYISGGVHLANILASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWH-ESLT 518
            |.|..:|||||:........:..||..|:.|.:.|.|.|....|.:..|..|:|..||.| ...:
Human   491 VYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTS 555

  Fly   519 EWRVLVEHIYAYDIETNTWSVETKIPAPKFYTGVTAMGRTIFFVGGLDSTESIDRASAE-TMAYD 582
            ::..::...| |....:.|:....:...:...||......|:.|||....   :|...| ...||
Human   556 DYDDVLSCEY-YSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWN---NRCMVEIVQKYD 616

  Fly   583 LDTKEWWHEKDSWDSPNDVWES 604
            .|       ||.|....|:.||
Human   617 PD-------KDEWHKVFDLPES 631

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1812NP_608397.1 BTB 38..142 CDD:279045 43/105 (41%)
PHA03098 46..588 CDD:222983 155/559 (28%)
BACK 151..249 CDD:285009 22/107 (21%)
KELCH repeat 344..390 CDD:276965 17/47 (36%)
KELCH repeat 394..444 CDD:276965 18/49 (37%)
Kelch 406..458 CDD:128874 19/51 (37%)
Kelch_1 448..492 CDD:279660 15/43 (35%)
KELCH repeat 448..492 CDD:276965 15/43 (35%)
Kelch_1 494..539 CDD:279660 10/45 (22%)
KELCH repeat 495..539 CDD:276965 10/44 (23%)
KLHL13XP_011529711.1 BTB_POZ_KLHL9_13 75..202 CDD:349548 47/127 (37%)
PHA03098 98..641 CDD:222983 160/575 (28%)
KELCH repeat 385..433 CDD:276965 17/48 (35%)
KELCH repeat 437..481 CDD:276965 18/50 (36%)
KELCH repeat 484..529 CDD:276965 16/44 (36%)
KELCH repeat 531..580 CDD:276965 10/49 (20%)
KELCH repeat 583..630 CDD:276965 15/56 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45416
OrthoDB 1 1.010 - - D133095at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45632
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
55.030

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