Protein Alignment CG1812 and KLHL6

DIOPT Version :10

• Sequence 1: NP_608397.1
• Gene: CG1812 / 33049
• FlyBaseID: FBgn0031119
• Length: 616
• Species: Drosophila melanogaster
• Sequence 2: NP_569713.2
• Gene: KLHL6 / 89857
• HGNCID: 18653
• Length: 621
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 149/595 - (25%)
• Similarity: 248/595 - (41%)
• Gaps: 100/595 - (16%)

  Fly    34 LLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKAR 98
            |..||..||.|..||||.|.|:...|..|||||||:|:||.|||.: .:.|..:..|.:.|:.|.
Human    58 LQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCN-DLKEKYEKRIIIKGVDAE 121

  Fly    99 AMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGI 163
            .|.:::||.|||...:...|::.:|.||...|...::|.|..||...:..|||:.|..:||.:.:
Human   122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSL 186

  Fly   164 MDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQLNES 228
            ..|.::...|:..:|.:...:.:|.::.||.|..||.|: .:.|.|            |.|:.|:
Human   187 DSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSD-DLYVTE------------EAQVFET 238

  Fly   229 ALGDLLRLIKWQHISYKSVDELRNMNCSLD---KGKQLPLPTSYY------------------NR 272
                   ::.|  :.:|..:.|    |.|.   :..:|||...:|                  ..
Human   239 -------VMSW--VRHKPSERL----CLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPL 290

  Fly   273 IKQEHMGHLLNGVVSLKDQSLPQGPTNMRGMELCLLKIGGFEWNGLTN------VIMCFSPKKMN 331
            :::..|.| |:|...:.:::.|:    |...:..:..|.|    |.|.      .:.|..|.:.:
Human   291 LQEARMYH-LSGNEIISERTKPR----MHEFQSEVFMIIG----GCTKDERFVAEVTCLDPLRRS 346

  Fly   332 WYELTAIPHIDQ---------CNFGTAVLNNKLFIVGGAYDVFLKEYIHPFGFCYCPLRNTWMTI 387
            ..|:..:|..:.         ..|....|.|:::|.||      ||..|.. :.|....|.|:.|
Human   347 RLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGG------KETQHDV-WKYNSSINKWIQI 404

  Fly   388 APIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHA 452
            ..:...|.|..:..:|.: :|.:||.      :.|:.|:|||.||...|.|:....|..:.|..|
Human   405 EYLNIGRWRHKMVVLGGK-VYVIGGF------DGLQRINNVETYDPFHNCWSEAAPLLVHVSSFA 462

  Fly   453 GVVVGDKLYISGGVHLANILA-SMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWHES 516
            ......|||:.||.....:.. ....:|..|..|...|:||........|:..:|||..||
Human   463 ATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG---- 523

  Fly   517 LTEWRVLVEHIYAYDIETNTWSVETKIPAPKFYTGVTAMGRTIFFVGGLDSTESIDRASAETMAY 581
                  .:..:|||....::|.:.|::...:...|:......::..||.|....:   .|..:.:
Human   524 ------AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEV---IATVLCW 579

  Fly   582 DLDTKEWWHE 591
            |.:.::...|
Human   580 DPEAQKLTEE 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB_POZ	33..151	CDD:453885	46/116 (40%)
		PHA03098	46..588	CDD:222983	142/578 (25%)
		KELCH repeat	344..390	CDD:276965	13/45 (29%)
		KELCH repeat	394..444	CDD:276965	15/49 (31%)
		KELCH repeat	448..492	CDD:276965	11/44 (25%)
		KELCH repeat	495..539	CDD:276965	10/43 (23%)
KLHL6	NP_569713.2	BTB_POZ_KLHL6	48..176	CDD:349545	48/118 (41%)
		PHA03098	86..565	CDD:222983	130/538 (24%)
		BACK_KLHL6	169..276	CDD:350521	30/132 (23%)
		Kelch 1	320..367		8/50 (16%)
		KELCH repeat	370..407	CDD:276965	13/43 (30%)
		Kelch 2	378..421		12/49 (24%)
		KELCH repeat	411..455	CDD:276965	15/50 (30%)
		Kelch 3	422..468		15/52 (29%)
		KELCH repeat	458..504	CDD:276965	12/45 (27%)
		Kelch 4	470..516		11/45 (24%)
		KELCH repeat	506..546	CDD:276965	11/49 (22%)
		Kelch 5	517..558		11/50 (22%)
		KELCH repeat	548..593	CDD:276965	7/45 (16%)
		Kelch_1	548..585	CDD:396078	6/39 (15%)
		Kelch 6	560..606		6/33 (18%)