DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG1812 and KLHL36

DIOPT Version :9

Sequence 1:NP_608397.1 Gene:CG1812 / 33049 FlyBaseID:FBgn0031119 Length:616 Species:Drosophila melanogaster
Sequence 2:NP_079007.2 Gene:KLHL36 / 79786 HGNCID:17844 Length:616 Species:Homo sapiens


Alignment Length:618 Identity:166/618 - (26%)
Similarity:267/618 - (43%) Gaps:89/618 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 TLLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKA 97
            |:|:.||:.|......||.|:.:|.|..|||.:||..||||.:||. ..|.|:.:.|:.|.|...
Human    31 TVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFT-IGMREAFQKEVELIGASY 94

  Fly    98 RAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYG 162
            ..:.:::|::|...|.|:..||:.:|..|..:|:..|:|.|..:|..::..:|.|.:..:|.||.
Human    95 IGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYS 159

  Fly   163 IMDLSERAYRYMCAHFEEFATTSDF-KEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQLN 226
            :..|......::..||...:.|.|| :.:.:.:|...|||:......|.||::....:..:|...
Human   160 LKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPER 224

  Fly   227 ESALGDLLRLIKWQHISYKS-VDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVVSLKD 290
            |:....:|..|.:..|.... :..::...|||     ||...:....|::....|     .:|..
Human   225 EAHARQVLENIHFPLIPKNDLLHRVKPAVCSL-----LPKEANCEGFIEEAVRYH-----NNLAA 279

  Fly   291 QSLPQGP-TNMRGMELCLLKIGG------FEWNGLTNVIMCF-SPKKMNWYELTAIP--HIDQCN 345
            |.:.|.. |.:|..:..||.:||      .|.:..|    |: ..|...|.:.|.:|  ....| 
Human   280 QPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDT----CYLDAKSEQWVKETPLPARRSHHC- 339

  Fly   346 FGTAVLNNKLFIVGGAYDVFLKEYIHPFG--------FCYCPLRNTWMTIAPIQQDRCRFSLNAV 402
              .|||...:||.||::.       ...|        :.|.|....|:.:|.:.|.|..|.|.::
Human   340 --VAVLGGFIFIAGGSFS-------RDNGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASI 395

  Fly   403 GTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISG--- 464
             ...|.|:||    .||..  .:|:||.|....:.|:|:..|......|||.:..|.:||||   
Human   396 -EDMLVAIGG----RNENG--ALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDFVYISGGHD 453

  Fly   465 ---GVHLANILASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWH---ESLTEWRVL 523
               |.:..|:|.    :|.:|:||:|...|.|....|.:.::.:.||:.||..   ||:..:.||
Human   454 YQIGPYRKNLLC----YDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVL 514

  Fly   524 VEHIYAYDIETNTWSVETKIPAPKFY----TGVTAMGRTIFFVGGLDSTESIDRASAETMAYDLD 584
              .:.||..:.|.|   |:: ||..:    :||......|:.:||.         |.|..|:...
Human   515 --GVEAYSPQCNQW---TRV-APLLHANSESGVAVWEGRIYILGGY---------SWENTAFSKT 564

  Fly   585 TKEWWHEKDSW----DSPNDV-WESTCVAIYVP 612
            .:.:..|.|.|    |.|..: ..|.||....|
Human   565 VQVYDREADKWSRGVDLPKAIAGGSACVCALEP 597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1812NP_608397.1 BTB 38..142 CDD:279045 36/103 (35%)
PHA03098 46..588 CDD:222983 152/574 (26%)
BACK 151..249 CDD:285009 22/99 (22%)
KELCH repeat 344..390 CDD:276965 13/53 (25%)
KELCH repeat 394..444 CDD:276965 15/49 (31%)
Kelch 406..458 CDD:128874 16/51 (31%)
Kelch_1 448..492 CDD:279660 16/49 (33%)
KELCH repeat 448..492 CDD:276965 16/49 (33%)
Kelch_1 494..539 CDD:279660 13/47 (28%)
KELCH repeat 495..539 CDD:276965 13/46 (28%)
KLHL36NP_079007.2 BTB 36..139 CDD:279045 36/103 (35%)
PHA03098 45..585 CDD:222983 157/590 (27%)
BACK 149..250 CDD:285009 22/100 (22%)
Kelch 1 296..345 15/55 (27%)
Kelch <317..345 CDD:128874 8/30 (27%)
Kelch_1 334..384 CDD:279660 13/59 (22%)
KELCH repeat 335..383 CDD:276965 13/57 (23%)
Kelch 2 346..397 13/58 (22%)
Kelch_1 386..431 CDD:279660 15/51 (29%)
KELCH repeat 387..431 CDD:276965 15/50 (30%)
Kelch 3 398..444 16/51 (31%)
KELCH repeat 434..481 CDD:276965 17/50 (34%)
Kelch 446..493 CDD:128874 15/50 (30%)
Kelch 4 446..493 15/50 (30%)
KELCH repeat 483..533 CDD:276965 16/55 (29%)
Kelch_1 486..532 CDD:279660 15/51 (29%)
Kelch 5 494..546 17/57 (30%)
KELCH repeat 536..582 CDD:276965 12/54 (22%)
Kelch 6 547..595 14/56 (25%)
Kelch 547..593 CDD:128874 13/54 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..616 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45416
OrthoDB 1 1.010 - - D133095at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45632
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
55.030

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