DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and klhl14

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	XP_001334729.4	Gene:	klhl14 / 794722	ZFINID:	ZDB-GENE-091204-223	Length:	616	Species:	Danio rerio

Alignment Length:	650	Identity:	165/650 - (25%)
Similarity:	285/650 - (43%)	Gaps:	131/650 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ETLLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIK 96
            :|||.|||.|..::...||||..:..:|..||.|||:.|.||.::|:..:|: ||:|     |:.
Zfish    26 DTLLHGLNLLWRKQLFCDVTLTAQGQQFHCHRAVLASCSQYFRSLFSTHSML-SRED-----GLA 84

  Fly    97 ARAMGS-----------------------------------IIDYIYTSMLELNYDNIEEILAAA 126
            |:..||                                   :::|:||:.:.|:.|.:||:|:.:
Zfish    85 AKDQGSSGTPSSSPDDKLLPSPHSTINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVS 149

  Fly   127 THVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEEFATTSDFKEM- 190
            ..:.:.::......||..:|.::|...|..:|.::|:.:..:.|.:|:.    |.....:|:||
Zfish   150 KILNIPQITKLSVQFLNDQISVQNYKQICKIAALHGLDETKKLANKYLV----EDVLLLNFEEMC 210

  Fly   191 -KVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQLNESAL---GDLLRLIKWQHI-------SY 244
             .:|.|        |..| |.:|.....|....:...|:.:   .||::.:::..|       ..
Zfish   211 AMLDAL--------PPPV-ESELALFQMSVLWLEHDRETRMHYAPDLMKRLRFALIPAPELVERV 266

  Fly   245 KSVDELRN-----------MNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVVSLKDQSLPQGPT 298
            :|||.:|:           ||..|...:|....|: .:||:......||.|       .||.||.
Zfish   267 QSVDFMRSDPVCQKLLLDAMNYHLMPFRQHCRQTT-ASRIRSNKRMLLLVG-------GLPPGPD 323

  Fly   299 NMRGMELCLLKIGGFEWNGLTNVIMCFSPKKMNWYELTAIPHIDQCNFGTAVLNNKLFIVGGAYD 363
            .:.                 :|::..:..:|..|..||.:|: :..:.....:.|.|.::||. |
Zfish   324 RLP-----------------SNLVQYYDDEKKTWKILTIMPY-NSAHHCVVEVENFLLLLGGE-D 369

  Fly   364 VFLKEYIHPFGFC--YCPLRNTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRMIS 426
            .:.....|...|.  |.|..|:|:.:.|:|:.|..|....: .:|||.|||    .||..  .:|
Zfish   370 QWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFFACCL-DKHLYVVGG----RNETG--YLS 427

  Fly   427 NVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHLANILASMWVFDTKTEVWQELASM 491
            :||.|::..|.|.|:.||.:..:.|||.|...|:|||||||....::.::.:|...:||.....|
Zfish   428 SVEAYNLETNEWNYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVSWLYCYDPVMDVWARKQDM 492

  Fly   492 PTPCCDHVLVAVDNRIYACGGWH-ESLTEWRVLVEHIYAYDIETNTWSV-ETKIPAPKFYTGVTA 554
            .|....|.|..:::|:||.||.| :..:...|::  :..||.:.:.||: :|.|...:...|...
Zfish   493 NTKRAIHALAGMNDRLYAIGGNHLKGFSHLDVML--VECYDPKADQWSILQTPILEGRSGPGCAV 555

  Fly   555 MGRTIFFVGGLDSTESIDRASAETMAYDLDTKEWWHEKDSW-DSPNDVWE----STCVAIYVPNC 614
            :..:|:.|||.  :.|:....:.|:.|.       .||.:| :...:|.|    ..|..:.:|.|
Zfish   556 LDDSIYLVGGY--SWSMGAYKSSTICYS-------PEKATWTEMEGEVAEPLAGPACATVILPAC 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	33/138 (24%)
		PHA03098	46..588	CDD:222983	150/603 (25%)
		BACK	151..249	CDD:285009	22/109 (20%)
		KELCH repeat	344..390	CDD:276965	11/47 (23%)
		KELCH repeat	394..444	CDD:276965	17/49 (35%)
		Kelch	406..458	CDD:128874	21/51 (41%)
		Kelch_1	448..492	CDD:279660	15/43 (35%)
		KELCH repeat	448..492	CDD:276965	15/43 (35%)
		Kelch_1	494..539	CDD:279660	12/45 (27%)
		KELCH repeat	495..539	CDD:276965	12/44 (27%)
klhl14	XP_001334729.4	BTB	32..165	CDD:279045	33/138 (24%)
		PHA03098	39..588	CDD:222983	152/612 (25%)
		BACK	177..265	CDD:197943	20/100 (20%)
		KELCH repeat	351..398	CDD:276965	11/47 (23%)
		Kelch	374..408	CDD:128874	10/33 (30%)
		KELCH repeat	402..446	CDD:276965	18/50 (36%)
		Kelch	413..459	CDD:128874	21/51 (41%)
		Kelch_1	448..493	CDD:279660	15/44 (34%)
		KELCH repeat	449..494	CDD:276965	16/44 (36%)
		KELCH repeat	496..540	CDD:276965	13/45 (29%)
		Kelch	507..558	CDD:128874	14/52 (27%)
		Kelch_1	548..590	CDD:279660	11/50 (22%)
		KELCH repeat	548..590	CDD:276965	11/50 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45416
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45632
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.030