DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1812 and klhdc8a

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	XP_001334194.3	Gene:	klhdc8a / 794258	ZFINID:	ZDB-GENE-120810-3	Length:	354	Species:	Danio rerio

Alignment Length:	347	Identity:	84/347 - (24%)
Similarity:	132/347 - (38%)	Gaps:	96/347 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 LLKIGGFEWNGL-TNVIMCFSPKKMNWYELTAIPHIDQCNFGTAVLNNKLFIVGG---------A 361
            |..:||.:.:|. |:.:..:||:...|..|..:| ..:.....|||..:|.:|||         |
Zfish    33 LYLVGGCDASGQPTSALELYSPEVDRWLSLPPMP-TPRAGAAVAVLGKQLLVVGGMGKEQRPLKA 96

  Fly   362 YDVFLKEYIHPFGFCYCPLRNT----WMTIAPIQQDRCRFSLNAVGTQ------HLYAVGGILDD 416
            .:|:                ||    |       :.||.....::|..      ...||||:..|
Zfish    97 VEVY----------------NTDEGKW-------RKRCSLREASMGVSVTVKDGRALAVGGMGPD 138

  Fly   417 DNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHLANILASMWVFDTK 481
                 |...|.:::||:.|:||..:|::...|...:..::|.|:|::||.....::.:..|||.:
Zfish   139 -----LLPRSVLQQYDLRKDVWALLPAMPTPRYDTSICLLGSKIYVAGGRQCKRLVKAFEVFDME 198

  Fly   482 TEVWQELASMPTPCCDHVLVAV--DNRIYAC-------GGWHESLTEWRVLVEHIYAYDIETNTW 537
            ...|..|.|:|   |......|  |:....|       ||.|:|    ....:::..:|.....|
Zfish   199 NRTWSSLPSLP---CKRSYSGVLWDSAGCLCWLGGLRQGGIHQS----SKFTKNVNIFDTNKGVW 256

  Fly   538 -----SVETKIPAPKFYTGVTAMGRTIFFVGGLDSTESIDRASAETMAYDLDTKEWWH-EKDSWD 596
                 :|..|.....|...: ..||.| ..|||....|:           |||.|.:| ||..|:
Zfish   257 LKSEDTVPLKTKRADFAAAI-VRGRMI-VAGGLGHQPSV-----------LDTVEAFHPEKRKWE 308

  Fly   597 --SPNDVWESTCVAIYVPNCDA 616
              ||          :..|.|.|
Zfish   309 RLSP----------MATPRCSA 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045
		PHA03098	46..588	CDD:222983	74/314 (24%)
		BACK	151..249	CDD:285009
		KELCH repeat	344..390	CDD:276965	12/58 (21%)
		KELCH repeat	394..444	CDD:276965	16/55 (29%)
		Kelch	406..458	CDD:128874	14/51 (27%)
		Kelch_1	448..492	CDD:279660	12/43 (28%)
		KELCH repeat	448..492	CDD:276965	12/43 (28%)
		Kelch_1	494..539	CDD:279660	10/58 (17%)
		KELCH repeat	495..539	CDD:276965	10/57 (18%)
klhdc8a	XP_001334194.3	KELCH repeat	21..65	CDD:276965	9/31 (29%)
		Kelch	32..79	CDD:128874	13/46 (28%)
		Kelch_1	68..109	CDD:279660	12/63 (19%)
		KELCH repeat	69..162	CDD:276965	28/120 (23%)
		mutarot_permut	70..334	CDD:274642	74/309 (24%)
		KELCH repeat	119..157	CDD:276965	13/42 (31%)
		Kelch	131..171	CDD:128874	14/44 (32%)
		KELCH repeat	165..209	CDD:276965	12/43 (28%)
		Kelch	176..217	CDD:128874	12/43 (28%)
		KELCH repeat	269..315	CDD:276965	18/68 (26%)
		Kelch_1	269..313	CDD:279660	18/66 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900