DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1812 and klhdc8a

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_001072317.1	Gene:	klhdc8a / 779770	XenbaseID:	XB-GENE-492242	Length:	350	Species:	Xenopus tropicalis

Alignment Length:	328	Identity:	76/328 - (23%)
Similarity:	126/328 - (38%)	Gaps:	55/328 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 LLKIGGFEWNG-LTNVIMCFSPKKMNWYELTAIPHIDQCNFGTAV--LNNKLFIVGGAYDVFLKE 368
            :..:||.:..| ..|....|||:...|..|..:|   ....|.||  |..::.:|||.
Frog    33 IFAVGGCDDAGNPMNSFEVFSPEANRWSSLEPMP---SSRAGVAVVALGKRIMVVGGV------- 87

  Fly   369 YIHPFGFCYCPLR---------NTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRM 424
                 |....||:         ..|...:.:::.....|: .|....:||.||:..|     ||.
Frog    88 -----GENQTPLKVVEVYNIDEGKWKKKSSLREPAMGISV-TVRDCRVYAAGGMGSD-----LRP 141

  Fly   425 ISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHLANILASMWVFDTKTEVWQELA 489
            ...:::||:.|::|.:...:...|......:.|.|:|:.||......:.:..|||.:|..|.:..
Frog   142 HCFLQQYDMLKDIWVHFAPMPTPRYGATSFLRGTKIYVLGGRQAKYAVNAFEVFDIETRSWTKFP 206

  Fly   490 SMPTPCCDHVLVAVDNRIYACGGWHESLTEWR-VLVEHIYAYDIETNTW-----SVETKIPAPKF 548
            |:|........|..:..:|:.||..:..|..| ...:.:..:|:|...|     |...:.....|
Frog   207 SIPNKRAYSRYVLSEGSLYSLGGLRQGGTYRRPKFTKTVDIFDMEQGGWMKTERSCFLRKRRADF 271

  Fly   549 YTGVTAMGRTIFFVGGLDSTESIDRASAETMAYDLDTKEWWHE-KDSWD--SPNDVWESTCVAIY 610
            ..| :..||.: ..|||.:..|:           |:|.|.:|. |..|:  ||.......|.:|.
Frog   272 VAG-SVHGRVV-VAGGLGNQPSV-----------LETAEIFHPVKSRWESLSPMPTPRCACASIV 323

  Fly   611 VPN 613
            :.|
Frog   324 LKN 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045
		PHA03098	46..588	CDD:222983	67/298 (22%)
		BACK	151..249	CDD:285009
		KELCH repeat	344..390	CDD:276965	11/56 (20%)
		KELCH repeat	394..444	CDD:276965	13/49 (27%)
		Kelch	406..458	CDD:128874	12/51 (24%)
		Kelch_1	448..492	CDD:279660	12/43 (28%)
		KELCH repeat	448..492	CDD:276965	12/43 (28%)
		Kelch_1	494..539	CDD:279660	9/50 (18%)
		KELCH repeat	495..539	CDD:276965	9/49 (18%)
klhdc8a	NP_001072317.1	PHA03098	<11..210	CDD:222983	46/197 (23%)
		KELCH repeat	21..65	CDD:276965	9/31 (29%)
		KELCH repeat	69..114	CDD:276965	11/56 (20%)
		KELCH repeat	117..163	CDD:276965	13/51 (25%)
		PHA03098	<145..349	CDD:222983	46/195 (24%)
		KELCH repeat	165..209	CDD:276965	12/43 (28%)
		KELCH repeat	268..313	CDD:276965	16/57 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000