DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and Klhl13

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_001368820.1	Gene:	Klhl13 / 67455	MGIID:	1914705	Length:	660	Species:	Mus musculus

Alignment Length:	594	Identity:	161/594 - (27%)
Similarity:	273/594 - (45%)	Gaps:	47/594 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LLRGLNKLRNEEKLTDVTLIV--EEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIK 96
            :|:|.::||.:..|.||||:.  .:..:..|||::|::||||.|||.. .|.|.....|.|:|:.
Mouse    83 VLQGFDQLRLDGLLCDVTLMPGDTDDAYPVHRVMMASASDYFKAMFTG-GMKEQELMCIKLHGVS 146

  Fly    97 ARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIY 161
            ...:..|||:|||:.|.||.|.:::.|.||:.:|:..|:|.|.:||.:.:.::||:.:..:|:.|
Mouse   147 RVGLRKIIDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTY 211

  Fly   162 GIMDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQLN 226
            .:.::.:....::..:|....:|.:|.::..::|.|:||||......|.||.:..|.:...::..
Mouse   212 HLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLEEPR 276

  Fly   227 ESALGDLLRLIKW------QHISY-KSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNG 284
            ......|::.|::      :.|:| ::||.:|..|..::    |.|..|.|.
Mouse   277 MDVAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVN----LLLEASNYQ------------- 324

  Fly   285 VVSLKDQSLPQGPTNMRGMELCLLKIGGFEWNGL--TNVIMCFSPKKMNWYELTAIPHIDQCNFG 347
            ::......:....|.:|.....|:.:||.....|  :..:..:..|...|..|..: ...:...|
Mouse   325 MMPFMQPVMQSDRTAIRSDTTRLVTLGGVLRQQLVVSKELRMYDEKTHEWKSLAPM-DAPRYQHG 388

  Fly   348 TAVLNNKLFIVGGA--YDVFLKEYIHPFGFCYCPLRNTWMTIAPIQQDRCRFSLNAVGTQHLYAV 410
            .||:.|.|::|||.  ||...|..:... |.:.|..|.|:.:|.:.:.|..|.|:|: ...||||
Mouse   389 IAVIGNFLYVVGGQSNYDTKGKTAVDTV-FRFDPRYNKWIQVASLNEKRTFFHLSAL-KGFLYAV 451

  Fly   411 GGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHLANILASM 475
            ||      ..|...:..||.|:...|.|||:..:.|....|||.|.|..:|||||:........:
Mouse   452 GG------RNAAGELPTVECYNPRTNEWTYVAKMNEPHYGHAGTVYGGVMYISGGITHDTFQKEL 510

  Fly   476 WVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWH-ESLTEWRVLVEHIYAYDIETNTWSV 539
            ..||..|:.|.:.|.|.|....|.:..|.:|:|..||.| ...:::..::...| |....:.|:.
Mouse   511 MCFDPDTDKWTQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSCEY-YSPILDQWTP 574

  Fly   540 ETKIPAPKFYTGVTAMGRTIFFVGGLDSTESIDRASAE-TMAYDLDTKEWWHEKDSWDSPNDVWE 603
            ...:...:...||......|:.|||....   :|...| ...||.:..||....|..:|...:..
Mouse   575 IASMLRGQSDVGVAVFENKIYVVGGYSWN---NRCMVEIVQKYDPEKNEWHKVFDLPESLGGIRA 636

  Fly   604 STCVAIYVP 612
            .| :.:|.|
Mouse   637 CT-LTVYPP 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	40/105 (38%)
		PHA03098	46..588	CDD:222983	150/556 (27%)
		BACK	151..249	CDD:285009	21/104 (20%)
		KELCH repeat	344..390	CDD:276965	16/47 (34%)
		KELCH repeat	394..444	CDD:276965	18/49 (37%)
		Kelch	406..458	CDD:128874	19/51 (37%)
		Kelch_1	448..492	CDD:279660	15/43 (35%)
		KELCH repeat	448..492	CDD:276965	15/43 (35%)
		Kelch_1	494..539	CDD:279660	10/45 (22%)
		KELCH repeat	495..539	CDD:276965	10/44 (23%)
Klhl13	NP_001368820.1	BTB_POZ_KLHL9_13	74..201	CDD:349548	44/118 (37%)
		PHA03098	97..640	CDD:222983	154/574 (27%)
		KELCH repeat	384..432	CDD:276965	16/48 (33%)
		KELCH repeat	436..480	CDD:276965	18/50 (36%)
		KELCH repeat	483..528	CDD:276965	16/44 (36%)
		KELCH repeat	530..579	CDD:276965	10/49 (20%)
		KELCH repeat	582..629	CDD:276965	13/49 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45416
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45632
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030