DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG1812 and KLHL42

DIOPT Version :9

Sequence 1:NP_608397.1 Gene:CG1812 / 33049 FlyBaseID:FBgn0031119 Length:616 Species:Drosophila melanogaster
Sequence 2:NP_065833.1 Gene:KLHL42 / 57542 HGNCID:29252 Length:505 Species:Homo sapiens


Alignment Length:645 Identity:144/645 - (22%)
Similarity:237/645 - (36%) Gaps:223/645 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 EKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEI------NLYGIKARAMGSI 103
            |::..:.|  |:..:...:..|...||||.|::.. .|.|:...|.      .|.|:.|..:..:
Human     4 EEMVQIRL--EDRCYPVSKRKLIEQSDYFRALYRS-GMREALSQEAGGPEVQQLRGLSAPGLRLV 65

  Fly   104 IDYIYT-----------------------SMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAK 145
            :|:|..                       .|.|::.  :.|::.||:.:||..::.    .|.::
Human    66 LDFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSL--LSELVEAASFLQVTSLLQ----LLLSQ 124

  Fly   146 IEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSS--NYPIDVA 208
            :.:.|||.:..:|.:||:.||.|...|:|..||.|......|         .:|.|  ..|.|| 
Human   125 VRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQF---------HLLGSPPQAPGDV- 179

  Fly   209 EQDLVRLVCSFAIEQQLNES---------ALGDLLRLIKWQHISYKSVDELRNMNCSLDKGKQLP 264
                       :::|:|.|:         ||||.|                        .|...|
Human   180 -----------SLKQRLREARMTGTPVLVALGDFL------------------------GGPLAP 209

  Fly   265 LPTSYY----NRIKQEHMGH----LLNGVVSLKDQSLPQGPTNMRGMELCLLKIGGFEWNGLTNV 321
            .|  |.    :.::.|.|..    |.|        :||....|:||                   
Human   210 HP--YQGEPPSMLRYEEMTERWFPLAN--------NLPPDLVNVRG------------------- 245

  Fly   322 IMCFSPKKMNWYELTAIPHIDQCNFGTAVLNNKLFIVGGAYDVFLKEYIHPFGFCYCPLRNTWMT 386
                                    :|:|:|:|.|||||| |.:..:|.  .....|.|..|.|:.
Human   246 ------------------------YGSAILDNYLFIVGG-YRITSQEI--SAAHSYNPSTNEWLQ 283

  Fly   387 IAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQH 451
            :|.:.|.|..|.|.||.:: |||:||          :.:||||.|:..::.|.::..|....::.
Human   284 VASMNQKRSNFKLVAVNSK-LYAIGG----------QAVSNVECYNPEQDAWNFVAPLPNPLAEF 337

  Fly   452 AGVVVGDKLYISGGV----HLANIL-----ASMW-VFDTKTEVWQELASMPTPCCD-HV----LV 501
            :......|:|:.||.    ...|||     :.|| :|:|               || |:    :|
Human   338 SACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFET---------------CDVHIRKQQMV 387

  Fly   502 AVDNRIYACGG-WHE-------SLTEWRVLVEHIYAYDIETNTWSVETKIPAPKFYTGVT-AMGR 557
            :|:..||..|| .||       |.:|..:.|:   :|:..|..| :..|....|....:| |:..
Human   388 SVEETIYIVGGCLHELGPNRRSSQSEDMLTVQ---SYNTVTRQW-LYLKENTSKSGLNLTCALHN 448

  Fly   558 TIFFVGGLDSTESIDRASAETMAYDLDTKEWWHEKDSWDS----PNDVWESTCVAIYVPN 613
            ...::...|.|.|........:.|::.:       |||::    |.........::|:||
Human   449 DGIYIMSRDVTLSTSLEHRVFLKYNIFS-------DSWEAFRRFPAFGHNLLVSSLYLPN 501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1812NP_608397.1 BTB 38..142 CDD:279045 24/125 (19%)
PHA03098 46..588 CDD:222983 136/613 (22%)
BACK 151..249 CDD:285009 27/108 (25%)
KELCH repeat 344..390 CDD:276965 17/45 (38%)
KELCH repeat 394..444 CDD:276965 16/49 (33%)
Kelch 406..458 CDD:128874 12/51 (24%)
Kelch_1 448..492 CDD:279660 11/53 (21%)
KELCH repeat 448..492 CDD:276965 11/53 (21%)
Kelch_1 494..539 CDD:279660 17/57 (30%)
KELCH repeat 495..539 CDD:276965 17/56 (30%)
KLHL42NP_065833.1 BTB_POZ_KLHL42 4..111 CDD:349628 22/111 (20%)
BACK_KLHL42_KLHDC5 128..237 CDD:350553 36/163 (22%)
Kelch 1 176..234 18/95 (19%)
PHA03098 <210..497 CDD:222983 86/379 (23%)
Kelch 2 235..282 20/92 (22%)
KELCH repeat 244..287 CDD:276965 19/88 (22%)
Kelch 3 284..325 17/51 (33%)
KELCH repeat 291..331 CDD:276965 16/50 (32%)
Kelch 4 327..372 9/44 (20%)
KELCH repeat 334..372 CDD:276965 8/37 (22%)
Kelch 5 374..429 19/73 (26%)
Kelch 6 431..480 10/55 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1072
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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