DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG1812 and KLHL9

DIOPT Version :9

Sequence 1:NP_608397.1 Gene:CG1812 / 33049 FlyBaseID:FBgn0031119 Length:616 Species:Drosophila melanogaster
Sequence 2:NP_061335.1 Gene:KLHL9 / 55958 HGNCID:18732 Length:617 Species:Homo sapiens


Alignment Length:586 Identity:161/586 - (27%)
Similarity:270/586 - (46%) Gaps:53/586 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 LLRGLNKLRNEEKLTDVTLIV--EEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIK 96
            :|:|.::||.|..|.||||:.  .:..|..||.::|::||||.|||.. .|.|.....|.|:|:.
Human    36 VLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTG-GMKEQDLMCIKLHGVN 99

  Fly    97 ARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIY 161
            ...:..|||:|||:.|.||.||:::.|.||:.:|:..|:|.|.:||.:.:.::||:.:..:|:.|
Human   100 KVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTY 164

  Fly   162 GIMDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQLN 226
            .::::.:....::..:|....:|.:|.::..::|.|:||||......|.:|.:..|.:...:...
Human   165 NLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPR 229

  Fly   227 ESALGDLLRLIKW------QHISY-KSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNG 284
            ......|::.|::      ..|:| ::||.:|..|..::    |.|..|.|.             
Human   230 MDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVN----LLLEASNYQ------------- 277

  Fly   285 VVSLKDQSLPQGPTNMRGMELCLLKIGGFEWNGL--TNVIMCFSPKKMNWYELTAIPHIDQCNFG 347
            ::......:....|.:|.....|:.:||.....|  :..:..:..:...|..|..: ...:...|
Human   278 MMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPM-DAPRYQHG 341

  Fly   348 TAVLNNKLFIVGGA--YDVFLKEYIHPFGFCYCPLRNTWMTIAPIQQDRCRFSLNAVGTQHLYAV 410
            .||:.|.|::|||.  ||...|..:... |.:.|..|.||.:|.:.:.|..|.|:|: ..|||||
Human   342 IAVIGNFLYVVGGQSNYDTKGKTAVDTV-FRFDPRYNKWMQVASLNEKRTFFHLSAL-KGHLYAV 404

  Fly   411 GGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHLANILASM 475
            ||      ..|...::.||.|:...|.|:|:..:.|....|||.|.|..:|||||:........:
Human   405 GG------RSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNEL 463

  Fly   476 WVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWH-ESLTEWRVLVEHIYAYDIETNTWSV 539
            ..||..|:.|.:.|.|.|....|.:..|.:::|..||.| ...:::..::...| |....:.|:.
Human   464 MCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEY-YSPTLDQWTP 527

  Fly   540 ETKIPAPKFYTGVTAMGRTIFFVGGLDSTESIDRASAE-TMAYDLDTKEWWHEKDSWDSPNDVWE 603
            ...:...:...||......|:.|||....   :|...| ...||       .|||.|....|:.|
Human   528 IAAMLRGQSDVGVAVFENKIYVVGGYSWN---NRCMVEIVQKYD-------PEKDEWHKVFDLPE 582

  Fly   604 S 604
            |
Human   583 S 583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1812NP_608397.1 BTB 38..142 CDD:279045 42/105 (40%)
PHA03098 46..588 CDD:222983 149/556 (27%)
BACK 151..249 CDD:285009 20/104 (19%)
KELCH repeat 344..390 CDD:276965 17/47 (36%)
KELCH repeat 394..444 CDD:276965 18/49 (37%)
Kelch 406..458 CDD:128874 19/51 (37%)
Kelch_1 448..492 CDD:279660 15/43 (35%)
KELCH repeat 448..492 CDD:276965 15/43 (35%)
Kelch_1 494..539 CDD:279660 9/45 (20%)
KELCH repeat 495..539 CDD:276965 9/44 (20%)
KLHL9NP_061335.1 BTB_POZ_KLHL9_13 27..154 CDD:349548 46/118 (39%)
PHA03098 50..593 CDD:222983 155/572 (27%)
Kelch 1 300..347 9/47 (19%)
KELCH repeat 337..385 CDD:276965 17/48 (35%)
Kelch 2 348..399 17/52 (33%)
KELCH repeat 389..433 CDD:276965 18/50 (36%)
Kelch 3 400..446 19/51 (37%)
KELCH repeat 436..481 CDD:276965 16/44 (36%)
Kelch 4 448..493 14/44 (32%)
KELCH repeat 483..532 CDD:276965 9/49 (18%)
Kelch 5 495..545 9/50 (18%)
KELCH repeat 535..582 CDD:276965 15/56 (27%)
Kelch 6 546..595 15/48 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 595..617
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45416
OrthoDB 1 1.010 - - D133095at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR45632
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
55.030

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