DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and klhl26

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_001038318.2	Gene:	klhl26 / 558035	ZFINID:	ZDB-GENE-030131-5975	Length:	605	Species:	Danio rerio

Alignment Length:	606	Identity:	178/606 - (29%)
Similarity:	287/606 - (47%)	Gaps:	70/606 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TLLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKA 97
            ||||||:.||::.:|.||.|.::..||:.|:.|||:.||||.|||.. .|.||.::.|.|.|:.|
Zfish    38 TLLRGLSALRDQGQLLDVVLAIDNERFEVHKAVLASCSDYFRAMFTG-GMKESNQNTIELIGLSA 101

  Fly    98 RAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYG 162
            |.:..|||:.|:|.:.|:.|.|:::|.||..:|:..|::.|..||.:.:.:|.||.|..||..:.
Zfish   102 RGLKHIIDFAYSSEVTLDLDCIQDVLGAAVFLQMVPVVELCEEFLKSAMSVETCLNIGQMATTFS 166

  Fly   163 IMDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQLNE 227
            :..|.:....|...||.:.|...||..:.:::|.|.|.||...:.:|.||......:........
Zfish   167 LSSLKQSVDAYTFRHFLQIAQEDDFLHIPMERLTFFLQSNKLKNCSEIDLFHAAIRWLQHDASRR 231

  Fly   228 SALGDLLRLIKWQHI-SYKSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVVSLKDQ 291
            :...::|..:::..: |.:.||.::.::.                .::.....|.|  :.:...|
Zfish   232 TVASEVLCHVRFPLMRSSELVDSVQIVDI----------------MVEDVQCRHFL--LEAFNYQ 278

  Fly   292 SLP------QGP-TNMRGMELCLLKIGGFEWNGLTNVI---MCFSP--KKMNWYELTAIPHIDQC 344
            .||      |.| |::|.....|:..||..:......:   :.|.|  ....:.|||.:..  .|
Zfish   279 ILPFRQHEMQSPRTSIRSDITSLITFGGTPYTDNDRTVSSKVYFLPDITVRQFKELTEMEM--GC 341

  Fly   345 NFG-TAVLNNKLFIVGGAYDVFLKEYIHPFG-----FCYCPLRNTWMTIAPIQQDRCRFSLNAVG 403
            :.. .:||:|.:::|||.:    .:|....|     |.|.|..|.|:.|.|:|:.|.:|.||.:.
Zfish   342 SHACVSVLDNFVYVVGGQH----LQYRSGEGAVDICFRYDPHLNQWLRIQPMQESRIQFQLNVLH 402

  Fly   404 TQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHL 468
            .| |||.||      ......:|:||.|...||.||.:.||:.....|||...|||||:|||..:
Zfish   403 GQ-LYATGG------RNRSGSLSSVECYCPKKNEWTNVDSLKRRIWGHAGATCGDKLYVSGGYGV 460

  Fly   469 A-NILASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWHESLTE-WRVL-VEHIYAY 530
            : ....::..:|:..:.|.....|..|...|.:::.:|||||.||..:.:.. :.|| ||:   |
Zfish   461 SVEDKKTLHCYDSALDQWDFKCPMNEPRVLHAMISANNRIYALGGRMDHVDRCFDVLAVEY---Y 522

  Fly   531 DIETNTWSVETKIPAPKFYTGVTAMGRTIFFVGG----LDSTESIDRASAETMAYDLDTKEWWHE 591
            ..||:.|:..:.:.|.:...|...:.:.|:.|||    |::..||      ...|:.:|.||  |
Zfish   523 IPETDQWTTVSPMRAGQSEAGCCLLDKKIYIVGGYNWHLNNVTSI------VQVYNTETDEW--E 579

  Fly   592 KDSWDSPNDVWESTCVAIYVP 612
            :| ...|.......|..|.:|
Zfish   580 RD-LHFPESFAGIACTPIILP 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	42/103 (41%)
		PHA03098	46..588	CDD:222983	162/567 (29%)
		BACK	151..249	CDD:285009	23/98 (23%)
		KELCH repeat	344..390	CDD:276965	15/51 (29%)
		KELCH repeat	394..444	CDD:276965	18/49 (37%)
		Kelch	406..458	CDD:128874	18/51 (35%)
		Kelch_1	448..492	CDD:279660	13/44 (30%)
		KELCH repeat	448..492	CDD:276965	13/44 (30%)
		Kelch_1	494..539	CDD:279660	17/46 (37%)
		KELCH repeat	495..539	CDD:276965	16/45 (36%)
klhl26	NP_001038318.2	BTB	43..147	CDD:279045	43/104 (41%)
		PHA03098	55..596	CDD:222983	166/584 (28%)
		BACK	155..256	CDD:285009	24/100 (24%)
		Kelch 1	300..351		11/52 (21%)
		Kelch_1	341..390	CDD:279660	16/52 (31%)
		KELCH repeat	342..389	CDD:276965	14/50 (28%)
		Kelch 2	352..403		17/54 (31%)
		KELCH repeat	393..437	CDD:276965	19/50 (38%)
		Kelch	404..450	CDD:128874	19/52 (37%)
		Kelch 3	404..450		19/52 (37%)
		KELCH repeat	440..486	CDD:276965	14/45 (31%)
		Kelch_6	441..488	CDD:290672	14/46 (30%)
		Kelch 4	452..498		10/45 (22%)
		Kelch_1	487..536	CDD:279660	17/51 (33%)
		KELCH repeat	488..535	CDD:276965	16/49 (33%)
		Kelch 5	499..549		16/52 (31%)
		KELCH repeat	539..580	CDD:276965	12/48 (25%)
		Kelch_1	540..580	CDD:279660	12/47 (26%)
		Kelch 6	551..598		16/55 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I7951
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45416
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_112332
Panther	1	1.100	-	-	O	PTHR45632
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.930