DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and klhl36

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	XP_005169991.1	Gene:	klhl36 / 553604	ZFINID:	ZDB-GENE-050522-324	Length:	613	Species:	Danio rerio

Alignment Length:	631	Identity:	174/631 - (27%)
Similarity:	279/631 - (44%)	Gaps:	109/631 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EEETLLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYG 94
            :...||:|||:.|...::.||.|:.::.|..|||.:||.||.||.|||. ..|.|..:.||.|.|
Zfish    35 QANNLLQGLNEQRQHGQMCDVVLVADDQRIPAHRALLAVSSPYFQAMFT-LGMREEHESEIELVG 98

  Fly    95 IKARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMAD 159
            .....:.::||::|:..|.|:..||:.:|..|..:||.:.:|.|..:|..::..:|.|.:..:|.
Zfish    99 ASYVGVKAVIDFLYSGNLPLDGGNIDYVLETAHLLQVWQAVDFCCQYLEKEVREDNYLYLQELAL 163

  Fly   160 IYGIMDLSERAYRYMCAHFEEFATTSDF-KEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQ 223
            :|.:..|.....|::..||...:.||:| :::::.:|...|||       ||           .|
Zfish   164 LYSLDRLDAFIDRFILKHFSTLSITSEFLQDVRMFKLCAYLSS-------EQ-----------VQ 210

  Fly   224 QLNESALGDLLRLIKW-----QHISYKSVDELRNMNCSL------------DKGKQLPLPTS--- 268
            .|||..|.::  ..||     :.:.: ::..|.|:..:|            :....|||.||
Zfish   211 CLNEETLFEV--AFKWLKQKPERLEF-ALQLLSNIRFALIPFYLLKYYVLPNVHSLLPLDTSCKV 272

  Fly   269 -------YYNRIKQEHMGHLLNGVVSLKDQSLPQGPTNMRGMELCLLKIGG---FEWNGLTNVIM 323
                   |:.::..:.:         ::.|.     |.:||...|||.:||   ....||:..:.
Zfish   273 LVEEAIDYHRKLSAQPV---------MQTQR-----TGLRGGVECLLLLGGEVSERGEGLSAEVC 323

  Fly   324 CFSPKKMNWYELTAI--PHIDQCNFGTAVLNNKLFIVGG----------AYDVFLKEYIHPFGFC 376
            ....:...|.|.|.:  |....|   .|||...:|..||          |.|:..:
Zfish   324 WLDEEAGKWVEETKMPAPRSQHC---VAVLGGFIFTAGGSCSPDNGGDSASDMLYR--------- 376

  Fly   377 YCPLRNTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYM 441
            |.|.|..|:..||:.|.|..|.|..:| :.|.||||..|..      .:|:||.|..|.:.|||:
Zfish   377 YDPRRCHWIKGAPMNQRRVDFYLGTMG-ECLIAVGGRNDSG------PLSSVEVYHPADDHWTYV 434

  Fly   442 PSLQENRSQHAGVVVGDKLYISGG--VHLANILASMWVFDTKT-EVWQELASMPTPCCDHVLVAV 503
            ..|.:....|||.:....:|||||  ..:......|..:|.|| :.|.|..:|......|.:.::
Zfish   435 AELPKFTYGHAGTIHKGIVYISGGHDYQIGPYRHDMLSYDPKTADAWNECQAMILARGWHSMASL 499

  Fly   504 DNRIYACGGW--HESLTEWRVLVEHIYAYDIETNTWSVETKIPAPKFYTGVTAMGRTIFFVGGLD 566
            ::||||.||.  ||...| |..|..:.|:|.:||.|::...:.......|:..:.|.|:.:||.
Zfish   500 EDRIYAIGGSDDHEDSME-RFDVLEVEAFDPQTNQWTMIAPLRYASSEAGLAVLNRKIYVLGGY- 562

  Fly   567 STESIDRASAETMAYDLDTKEWWHEKDSWDSPNDVWESTCVAIYVP 612
            |.|::| .|..|..:|.|.::|....   :.|..:...:||.:..|
Zfish   563 SWEAMD-FSQGTQVFDPDKEQWTLGP---NLPKHIAGPSCVCLIKP 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	38/103 (37%)
		PHA03098	46..588	CDD:222983	163/589 (28%)
		BACK	151..249	CDD:285009	23/103 (22%)
		KELCH repeat	344..390	CDD:276965	14/55 (25%)
		KELCH repeat	394..444	CDD:276965	18/49 (37%)
		Kelch	406..458	CDD:128874	18/51 (35%)
		Kelch_1	448..492	CDD:279660	14/46 (30%)
		KELCH repeat	448..492	CDD:276965	14/46 (30%)
		Kelch_1	494..539	CDD:279660	17/46 (37%)
		KELCH repeat	495..539	CDD:276965	17/45 (38%)
klhl36	XP_005169991.1	BTB	43..146	CDD:279045	38/103 (37%)
		PHA03098	53..593	CDD:222983	165/600 (28%)
		BACK	155..248	CDD:197943	26/113 (23%)
		Kelch	<324..352	CDD:128874	8/30 (27%)
		Kelch_1	341..391	CDD:279660	16/61 (26%)
		KELCH repeat	342..390	CDD:276965	14/59 (24%)
		Kelch_1	393..438	CDD:279660	18/51 (35%)
		KELCH repeat	394..438	CDD:276965	18/50 (36%)
		KELCH repeat	442..487	CDD:276965	14/44 (32%)
		KELCH repeat	491..540	CDD:276965	17/49 (35%)
		Kelch	502..553	CDD:128874	17/51 (33%)
		KELCH repeat	544..590	CDD:276965	13/50 (26%)
		Kelch_1	545..590	CDD:279660	13/49 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45416
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45632
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.030