DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1812 and KLHDC8A

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_001258792.1	Gene:	KLHDC8A / 55220	HGNCID:	25573	Length:	350	Species:	Homo sapiens

Alignment Length:	333	Identity:	81/333 - (24%)
Similarity:	135/333 - (40%)	Gaps:	69/333 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 IGGFEWNGLTNVIMCF---SPKKMNWYELTAIPHIDQCNFGTAV--LNNKLFIVGGAYDVFLKEY 369
            |||.:.||:.  :.||   ||:...|   ||:|.:.....|.||  |..::.::||.
Human    36 IGGCDDNGVP--MDCFEVYSPEADQW---TALPRLPTARAGVAVTALGKRIMVIGGV-------- 87

  Fly   370 IHPFGFCYCPLR---------NTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGI-LDDDNEEALRM 424
                |....||:         ..|...:.:::.....|:.| ....:||.||: ||      ||.
Human    88 ----GTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTA-KDYRVYAAGGMGLD------LRP 141

  Fly   425 ISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHLANILASMWVFDTKTEVWQELA 489
            .::::.||:.|::|..:..:...|......:.|.|:|:.||......:.:..|||.:|..|.:..
Human   142 HNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIETRSWTKFP 206

  Fly   490 SMPTPCCDHVLVAVDNRIYACGGWHES-LTEWRVLVEHIYAYDIETNTW-----SVETKIPAPKF 548
            ::|........|.:||.:|:.||..:. |......:..:..:|:|...|     |...|.....|
Human   207 NIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADF 271

  Fly   549 YTGVTAMGRTIFFVGGLDSTESIDRASAETMAYDLDTKEWWHE-KDSWD------SPNDVWESTC 606
            ..| :..||.| ..|||.:..::           |:|.|.:|. |:.|:      :|    ...|
Human   272 VAG-SLSGRVI-VAGGLGNQPTV-----------LETAEAFHPGKNKWEILPAMPTP----RCAC 319

  Fly   607 VAIYVPNC 614
            .:|.|.||
Human   320 SSIVVKNC 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045
		PHA03098	46..588	CDD:222983	71/298 (24%)
		BACK	151..249	CDD:285009
		KELCH repeat	344..390	CDD:276965	10/56 (18%)
		KELCH repeat	394..444	CDD:276965	14/50 (28%)
		Kelch	406..458	CDD:128874	13/52 (25%)
		Kelch_1	448..492	CDD:279660	11/43 (26%)
		KELCH repeat	448..492	CDD:276965	11/43 (26%)
		Kelch_1	494..539	CDD:279660	10/50 (20%)
		KELCH repeat	495..539	CDD:276965	10/49 (20%)
KLHDC8A	NP_001258792.1	Kelch 1	1..31
		BTB	<5..209	CDD:333434	48/196 (24%)
		KELCH repeat	21..65	CDD:276965	13/33 (39%)
		Kelch 2	32..79		17/47 (36%)
		KELCH repeat	69..162	CDD:276965	24/111 (22%)
		Kelch 3	81..127		8/58 (14%)
		Kelch 4	128..175		13/52 (25%)
		BTB	<129..333	CDD:333434	56/222 (25%)
		KELCH repeat	165..210	CDD:276965	11/44 (25%)
		Kelch 5	176..222		11/45 (24%)
		Kelch 6	224..278		11/54 (20%)
		KELCH repeat	268..314	CDD:276965	14/58 (24%)
		Kelch 7	279..326		15/62 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900