DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG1812 and KLHL11

DIOPT Version :10

Sequence 1:NP_608397.1 Gene:CG1812 / 33049 FlyBaseID:FBgn0031119 Length:616 Species:Drosophila melanogaster
Sequence 2:NP_060613.1 Gene:KLHL11 / 55175 HGNCID:19008 Length:708 Species:Homo sapiens


Alignment Length:647 Identity:129/647 - (19%)
Similarity:238/647 - (36%) Gaps:157/647 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 PAATATSAAAKIPVNPVSPEEE---------TLLRGLNKLRNEEKLTDVTLI---VEEHRFKAHR 63
            |..:|..|:...|    .||.|         .|....|:.|.:....|:||.   .....|:|||
Human    52 PGISAMEASGGDP----GPEAEDFECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHR 112

  Fly    64 VVLAASSDYFCAMFADCAMIESRKDEINLY------GIKARAMGSIIDYIYTSMLELNYDNIEEI 122
            .||||:::||..:.:. ...|||...:.:.      |.:...:.::|:|:||..:.::..::.|:
Human   113 SVLAAATEYFTPLLSG-QFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEV 176

  Fly   123 LAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEEFATTSDF 187
            |..|....:..:.:.|..||..|:.:.||:||..:|.:|.:..|:.:|...:..:|.:.....:|
Human   177 LELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEF 241

  Fly   188 KEMKVDQLRFILSS-NYPIDVAE---QDLVRLVCSFAIEQQLNESALGDLLRLIKWQHISYKSVD 248
            ..:....:|..||. ...:|..|   :.:::.|...|.|::.....|..||||.:.:        
Human   242 YTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMK-------- 298

  Fly   249 ELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVV------------SLKDQSLPQG----P 297
                             ||.....:|.|.:  :.|..|            :|:.:::..|    |
Human   299 -----------------PTYLTRHVKPERL--VANNEVCVKLVADAVERHALRAENIQSGTCQHP 344

  Fly   298 TNM--------RGMELCLLKIGGFEWNG--LTNVIMCFSPKKMNWYELTAI-PHIDQCNFGTAVL 351
            |:.        :.|:: ::.|||....|  |:..:..|..:. .|..|..| .|:|  ....||.
Human   345 TSHVSLLPRYGQNMDV-IMVIGGVSEGGDYLSECVGYFVDED-RWVNLPHIHNHLD--GHAVAVT 405

  Fly   352 NNKLFIVGGAYDVFLKEYIHPFGFCYCPLRNTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDD 416
            .:.:::.|.....|.|....     |.|..|||..:..:...:..|.|..|..: ||::||    
Human   406 ESYVYVAGSMEPGFAKTVER-----YNPNLNTWEHVCSLMTRKHSFGLTEVKGK-LYSIGG---- 460

  Fly   417 DNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDK-LYISGGVHL-----ANILASM 475
             :........:|..|:...:.|..:.|..:.......:.:.|: :||:....:     ..:.|.:
Human   461 -HGNFSPGFKDVTVYNPELDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVI 524

  Fly   476 WVFDTKTEVWQELASMP--------------------TPCC--------------------DHVL 500
            ..:||:|..||::.|:|                    ..||                    |.:|
Human   525 TCYDTETRQWQDVESLPLIDNYCFFQMSVVNSNFYQTASCCPKSYCLENEEAVRKIASQVSDEIL 589

  Fly   501 VAV---------------DNRIYACGGWHESLTEWRVLVEHIYAYDIETNTWSVETKIPAPK 547
            .::               .:.::..|||..|....:...:..|.|..|...|.:...:|.|:
Human   590 ESLPPEVLSIEGAAICYYKDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPMPQPR 651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1812NP_608397.1 BTB_POZ 33..151 CDD:453885 31/126 (25%)
PHA03098 46..588 CDD:222983 119/603 (20%)
KELCH repeat 344..390 CDD:276965 10/45 (22%)
KELCH repeat 394..444 CDD:276965 10/49 (20%)
KELCH repeat 448..492 CDD:276965 10/49 (20%)
KELCH repeat 495..539 CDD:276965 12/78 (15%)
KLHL11NP_060613.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 47..70 6/21 (29%)
BTB_POZ_KLHL11 71..205 CDD:349550 31/134 (23%)
PHA03098 90..553 CDD:222983 105/505 (21%)
BACK_KLHL11 200..287 CDD:350526 18/86 (21%)
Kelch 1 360..407 13/50 (26%)
KELCH repeat 399..439 CDD:276965 10/44 (23%)
Kelch 2 408..453 11/49 (22%)
KELCH repeat 443..488 CDD:276965 11/50 (22%)
Kelch 3 455..501 8/50 (16%)
KELCH repeat 491..541 CDD:276965 10/49 (20%)
Kelch 4 503..556 10/52 (19%)
KELCH repeat 567..649 CDD:276965 10/81 (12%)
Kelch 5 610..661 10/42 (24%)
Kelch 611..657 CDD:128874 10/41 (24%)

Return to query results.
Submit another query.