DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and klhl32

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	XP_012818485.1	Gene:	klhl32 / 549611	XenbaseID:	XB-GENE-5858956	Length:	657	Species:	Xenopus tropicalis

Alignment Length:	563	Identity:	161/563 - (28%)
Similarity:	262/563 - (46%)	Gaps:	62/563 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 EETLLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGI 95
            ::.:|..||:.||:..|.|:||:.||.:|.||:.||||.||||.|||:.| |:||..||:||:|:
Frog    62 KDAVLSALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLC-MVESEADEVNLHGV 125

  Fly    96 KARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADI 160
            .:..:...:|:.||..:.|....|:::|||.:|:|:.|:::.|:.:|..::...|.|.:..:||:
Frog   126 TSLGLKQALDFAYTGQILLEPGAIQDVLAAGSHLQLLELLNLCSQYLIQELNSFNYLDLYKLADL 190

  Fly   161 YGIMDLSERAYRYMCAHFEEFATT--SDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQ 223
            :.:..|......::..|..|....  .:...:....||.:|.|:....::|:.:.:|...: :|.
Frog   191 FNLTLLETAVVEFLVKHLSELLKNHPEEVLALPFRLLREVLKSDQLTSMSEEQIWQLAVRW-LEH 254

  Fly   224 QLNESALGDLLRLIKWQHISYKSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVVSL 288
            ......:.:||:.:::   .....:.|..:..|....:.....|:..|...:.|
Frog   255 NCRYQYMDELLQYVRF---GLMDTNTLHTVALSHPLIQSSETATALINEALEYH----------- 305

  Fly   289 KDQSLPQGP------TNMRGMELCLLKIGGFEWNGLTNV--IMCFSPKKM---------NWYELT 336
              ||:...|      |..|.....|..:|| :...:..|  :..|:|...         ||.|||
Frog   306 --QSIYAQPVWQTIRTEPRFQSNTLYIVGG-KKREICKVRELRYFNPIDQENVHIAGIANWSELT 367

  Fly   337 AIPHIDQCNFGTAVLNNKLFIVGGAYDVFLKEYIHPFG-------FC-YCPLRNTWMTIAPIQQD 393
            .:| :.:.:...|::.|.||..||       |..|..|       .| |.|..|:|:.|||::..
Frog   368 PMP-VGRSHHCVAIMGNFLFAAGG-------EVEHASGRTCAVRTACRYDPRSNSWIEIAPMKNC 424

  Fly   394 RCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGD 458
            |..|.|.||| ..||||||     ..|..:::.:||||...||.||:..|...:.|.|||.|...
Frog   425 REHFVLGAVG-DLLYAVGG-----RNELRQVLPSVERYCPKKNKWTFAQSFDRSLSCHAGCVADG 483

  Fly   459 KLYISGGV-HLANILASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWHESLTEWRV 522
            .|:||||| :.|.....:.|:|.....|...:.|......|.:.||..::|..||........|:
Frog   484 LLWISGGVTNTAQYQNRLMVYDPSQNKWISRSPMLQRRVYHAMAAVQRKLYVLGGNDLDYNNDRI 548

  Fly   523 LVEHIYAYDIETNTWS-VETKIPAPKFYTGVTAMGRTIFFVGG 564
            ||.||.:|:|:|:.|: ....:...:..:||......|:.|||
Frog   549 LVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVYNGRIYLVGG 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	45/103 (44%)
		PHA03098	46..588	CDD:222983	156/548 (28%)
		BACK	151..249	CDD:285009	15/99 (15%)
		KELCH repeat	344..390	CDD:276965	16/53 (30%)
		KELCH repeat	394..444	CDD:276965	21/49 (43%)
		Kelch	406..458	CDD:128874	21/51 (41%)
		Kelch_1	448..492	CDD:279660	15/44 (34%)
		KELCH repeat	448..492	CDD:276965	15/44 (34%)
		Kelch_1	494..539	CDD:279660	15/45 (33%)
		KELCH repeat	495..539	CDD:276965	15/44 (34%)
klhl32	XP_012818485.1	BTB_POZ_KLHL32	51..183	CDD:349570	48/121 (40%)
		PHA03098	74..564	CDD:222983	150/522 (29%)
		BACK_KLHL32_BKLHD5	176..273	CDD:350546	16/100 (16%)
		KELCH repeat	373..421	CDD:276965	16/54 (30%)
		KELCH repeat	425..470	CDD:276965	22/50 (44%)
		KELCH repeat	473..519	CDD:276965	16/45 (36%)
		KELCH repeat	521..571	CDD:276965	15/49 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7141
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	1	1.000	-	-		FOG0009747
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010