DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1812 and Klhl33

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_001357693.1	Gene:	Klhl33 / 546611	MGIID:	3644593	Length:	793	Species:	Mus musculus

Alignment Length:	604	Identity:	145/604 - (24%)
Similarity:	239/604 - (39%)	Gaps:	96/604 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VTPAATATSAAAKIPVNPVSPEEETLLRGLNKLR-NEEKLT----------------------DV 50
            |..||.|..|........:.||      ||.|.| ||:||:                      |:
Mouse   177 VLAAAEALGAPRVKKAAQLKPE------GLGKARGNEKKLSQAEELRENLHSIERLYREGIGCDL 235

  Fly    51 TLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKARAMGSIIDYIYTSMLELN 115
            .|..|.:|.:.|||.||..|::|.||... .|.||:..::.|..|.::.:..::.:.||.::...
Mouse   236 ELEAEGYRLRVHRVALACGSEFFGAMLLS-GMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRER 299

  Fly   116 YDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEE 180
            :..:.....||...|....:|.|...|...:....|||:..|.:..|:..:..:|:.|:.:|...
Mouse   300 WPGLLRAAQAALQYQSSSCLDLCQKALAQSLCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPA 364

  Fly   181 FATTSDFKEMKVDQLRFILSSNYPIDVAEQ----DLVRLVCSFAIEQQLNESALGDLLRLIKWQH 241
            .|:...|..:.|..|..:|.|: .:.|.|:    ...|  |..|...:.:||....|||.:::..
Mouse   365 VASCPTFSSLPVTCLAELLDSD-ELHVQEEFEAFSAAR--CWLAANPETHESEAKALLRCVRFGR 426

  Fly   242 ISYKSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVVSLKDQSLPQGPTNMRGMELC 306
            :|.:   |||.:..:   |....||.....::              :.:..:| |....|..:..
Mouse   427 MSTR---ELRKVRAA---GLPPSLPPDLLYQL--------------MVEAEVP-GQERWREPDQA 470

  Fly   307 LLKIGGFEWNGLTNVIMCFSP-----------------KKMNWYELTAIPHIDQCNFGTAVLNNK 354
            |:.|||   :||...:....|                 :.:.|..|..:|...:...|.|.|...
Mouse   471 LVVIGG---DGLRPDMDRRQPSCKVWWARAFHCGMGLVRTVEWCRLPNLPAPGRFRHGAASLTGS 532

  Fly   355 LFIVGGAYDVFLKEYIHPFGFCYCPLRNTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNE 419
            ...|.|..|.:...........:...:..|..:||:.|.|..|.| .|....|||:||   .||.
Mouse   533 ELYVCGGQDFYSHNSTLASTLRWSSSQEDWEEMAPLCQARSFFPL-VVFDGQLYALGG---RDNG 593

  Fly   420 EALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVH-LANILASMWVFDTKTE 483
            .||   ::||.|:...|||...|:|......||..::.|:||:|||.. ....|.|:..:|.|.:
Mouse   594 VAL---NSVETYNPELNVWRPAPALPAPCFAHAAAILEDRLYVSGGCSGTGQYLDSLIHYDPKLK 655

  Fly   484 VWQELAS-MPTPCCDHVLVAVDNRIYACGGWHES--LTEWRVLVEHIYAYDIETNTWSVETKIPA 545
            ....|.| |......||:.|:..::|..||..::  |..:.       ||:.::::|:....:|:
Mouse   656 RPGTLLSPMGVARASHVMAALGGKLYVAGGVGDTGDLLSFE-------AYEPKSDSWTQLASLPS 713

  Fly   546 PKFYTGVTAMGRTIFFVGG 564
            |........:...:..:||
Mouse   714 PHVGAAGAVLQGELLVLGG 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	32/126 (25%)
		PHA03098	46..588	CDD:222983	132/566 (23%)
		BACK	151..249	CDD:285009	25/101 (25%)
		KELCH repeat	344..390	CDD:276965	8/45 (18%)
		KELCH repeat	394..444	CDD:276965	20/49 (41%)
		Kelch	406..458	CDD:128874	19/51 (37%)
		Kelch_1	448..492	CDD:279660	14/45 (31%)
		KELCH repeat	448..492	CDD:276965	14/45 (31%)
		Kelch_1	494..539	CDD:279660	10/46 (22%)
		KELCH repeat	495..539	CDD:276965	10/45 (22%)
Klhl33	NP_001357693.1	BTB_POZ	91..189	CDD:365784	5/11 (45%)
		BTB_POZ	220..337	CDD:365784	27/117 (23%)
		PHA03098	319..738	CDD:222983	107/455 (24%)
		KELCH repeat	521..569	CDD:276965	9/47 (19%)
		KELCH repeat	572..615	CDD:276965	20/49 (41%)
		KELCH repeat	619..665	CDD:276965	14/45 (31%)
		KELCH repeat	668..713	CDD:276965	10/51 (20%)
		KELCH repeat	715..761	CDD:276965	2/18 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45632
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000