DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1812 and klhl13

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	XP_031746247.1	Gene:	klhl13 / 493457	XenbaseID:	XB-GENE-923144	Length:	655	Species:	Xenopus tropicalis

Alignment Length:	599	Identity:	171/599 - (28%)
Similarity:	270/599 - (45%)	Gaps:	79/599 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LLRGLNKLRNEEKLTDVTLIV--EEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIK 96
            :|:|.::||.|..|.||||:.  .:..|..||.::|:|||||.|||.. .|.|.....|.|:|:.
Frog    78 VLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASSSDYFKAMFTG-GMKEQDLMCIKLHGVN 141

  Fly    97 ARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIY 161
            ...:..|||:|||:.|.||.||:::.|.||:.:|:..|:|.|.:||.:.:.:|||:.:..:|:.|
Frog   142 KIGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLENCVEVGRIANTY 206

  Fly   162 GIMDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQLN 226
            .:.::.:....|:..:|....||.:|.::..|:|.|:||||......|.:|.:..|.:...:...
Frog   207 NLTEVDKYVNNYILKNFPALLTTGEFVKLPFDRLAFVLSSNSLKQCTELELFKAACRWLRYEDAR 271

  Fly   227 ESALGDLLRLIKW---------QHISYKSVDELRN----MNCSLDKGKQLPLPTSYYNRIKQEHM 278
            ......:::.|::         .|:  ::||.:|.    :|..|:......:|  |...:.|...
Frog   272 MEYAAKIMKNIRFPLMTPQDLINHV--QTVDFMRTDNTCVNLLLEASNYQMMP--YMQPVMQSER 332

  Fly   279 -------GHL--LNGVVSLKDQSLPQGPTNMRGMELCLLKIGGFEWNGLTNVIMCFSPKKMNWYE 334
                   .||  |.||  |:.|.:.       ..||.:....|.||..|       :|.....|:
Frog   333 TAIRSDNTHLVTLGGV--LRQQLVV-------SKELRMYDEKGHEWKSL-------APMDAPRYQ 381

  Fly   335 LTAIPHIDQCNFGTAVLNNKLFIVGGA--YDVFLKEYIHPFGFCYCPLRNTWMTIAPIQQDRCRF 397
                       .|.||:.|.|::|||.  ||...|..:... |.:.|..|.||.:|.:.:.|..|
Frog   382 -----------HGIAVIGNFLYVVGGQSNYDTKGKTAVDTV-FRFDPRYNKWMQVASLNEKRTFF 434

  Fly   398 SLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYI 462
            .|:|: ..|||||||      ..|...::.||.|:...|.|:|:..:.|....|||.|.|..:||
Frog   435 HLSAL-KGHLYAVGG------RNAAGELATVECYNPRTNEWSYVAKMNEPHYGHAGTVFGGLMYI 492

  Fly   463 SGGVHLANILASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWH-ESLTEWRVLVEH 526
            |||:........:..||..|:.|.:.|.|.|....|.:..|.:::|..||.| ...:::..::..
Frog   493 SGGITHDTFQKELMCFDPDTDKWTQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSC 557

  Fly   527 IYAYDIETNTWSVETKIPAPKFYTGVTAMGRTIFFVGGLDSTESIDRASAE-TMAYDLDTKEWWH 590
            .| |....:.|:....:...:...||......|:.|||....   :|...| ...||       .
Frog   558 EY-YSPSLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWN---NRCMVEIVQKYD-------P 611

  Fly   591 EKDSWDSPNDVWES 604
            |||.|....|:.||
Frog   612 EKDEWHKVFDLPES 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	43/105 (41%)
		PHA03098	46..588	CDD:222983	159/569 (28%)
		BACK	151..249	CDD:285009	21/106 (20%)
		KELCH repeat	344..390	CDD:276965	17/47 (36%)
		KELCH repeat	394..444	CDD:276965	18/49 (37%)
		Kelch	406..458	CDD:128874	19/51 (37%)
		Kelch_1	448..492	CDD:279660	15/43 (35%)
		KELCH repeat	448..492	CDD:276965	15/43 (35%)
		Kelch_1	494..539	CDD:279660	9/45 (20%)
		KELCH repeat	495..539	CDD:276965	9/44 (20%)
klhl13	XP_031746247.1	BTB_POZ_KLHL9_13	69..196	CDD:349548	48/118 (41%)
		PHA03098	92..635	CDD:222983	165/585 (28%)
		KELCH repeat	379..427	CDD:276965	18/59 (31%)
		KELCH repeat	431..475	CDD:276965	18/50 (36%)
		KELCH repeat	478..523	CDD:276965	16/44 (36%)
		KELCH repeat	525..574	CDD:276965	9/49 (18%)
		KELCH repeat	577..624	CDD:276965	15/56 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45416
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45632
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030