DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and Keap1

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster

Alignment Length:	583	Identity:	148/583 - (25%)
Similarity:	252/583 - (43%)	Gaps:	41/583 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKARA 99
            |:.:..:|:...||||.|.|::..|.||:|||:|:|.||.|||.. .:.||....:.|.|:...|
  Fly    77 LKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTG-GLKESEMSRVQLQGVCPTA 140

  Fly   100 MGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIM 164
            |..|:.::||..:.:....:.::|.|||..||..|||.|..||..:::..|.:.||..|:.:|.:
  Fly   141 MSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCV 205

  Fly   165 DLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFA-IEQQLNES 228
            :|.::|..::..:|.:.....:|.::...||..::..:......|:::...|..:. .::.....
  Fly   206 ELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHC 270

  Fly   229 ALGDLLRLIKWQHISYKSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVVSLKDQSL 293
            .:..:|..::.|.::...:.| :..||  |..:::|....|..:|.::...|...||   |:::
  Fly   271 KMEHILGAVRCQFLTPNFLKE-QMKNC--DVLRKVPACREYLAKIFKDLTLHKCPGV---KERT- 328

  Fly   294 PQGPTNMRGMELCLLKIGGFEWNGLTNVIMCFSPKKMNWYELTAIPHIDQCNFGTAVLNNKLFIV 358
               |...|    .:...|||..:.| :::..::...|.|..|..: .|.:...|.|.|..|.:.|
  Fly   329 ---PNTTR----MIFVAGGFFRHSL-DILEAYNVDDMTWTTLANL-RIPRSGLGAAFLKGKFYAV 384

  Fly   359 GGAYDVFLKEYIHPFGFCYCPLRNTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALR 423
            ||..:.....|...:...|..:..||...||:...|.|..: ||..:.:|||||      ...:.
  Fly   385 GGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGV-AVMDELMYAVGG------SAGME 442

  Fly   424 MISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHLANILASMWVFDTKTEVWQEL 488
            ..:.||.||...:.||.:..:...|.....|||...||..||......|||:..:..:...|..|
  Fly   443 YHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFL 507

  Fly   489 ASMPTPCCDHVLVAVDNRIYACGGWHESLTEWRVLVEHIYAYDIETNTWSVETKIPAPKFYTGVT 553
            ..:.|......:.|::..||..||:..  |.....||.   ||.|.:||.:...|...:....:|
  Fly   508 PPLQTGRSGAGVAAINQYIYVVGGFDG--TRQLATVER---YDTENDTWDMVAPIQIARSALSLT 567

  Fly   554 AMGRTIFFVGGLDSTESIDRASAETMAYDLDTKEWWHEKDSWDSPNDVWES--TCVAIYVPNC 614
            .:...::.:||.|....:....    .||..|..|     :..:|.....|  ....||.|.|
  Fly   568 PLDEKLYAIGGFDGNNFLSIVE----VYDPRTNTW-----TTGTPLKSGRSGHASAVIYQPAC 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	39/103 (38%)
		PHA03098	46..588	CDD:222983	139/542 (26%)
		BACK	151..249	CDD:285009	14/98 (14%)
		KELCH repeat	344..390	CDD:276965	12/45 (27%)
		KELCH repeat	394..444	CDD:276965	15/49 (31%)
		Kelch	406..458	CDD:128874	15/51 (29%)
		Kelch_1	448..492	CDD:279660	13/43 (30%)
		KELCH repeat	448..492	CDD:276965	13/43 (30%)
		Kelch_1	494..539	CDD:279660	13/44 (30%)
		KELCH repeat	495..539	CDD:276965	13/43 (30%)
Keap1	NP_732202.2	BTB	80..183	CDD:279045	39/103 (38%)
		PHA03098	92..599	CDD:222983	137/544 (25%)
		BACK	192..294	CDD:285009	15/102 (15%)
		Kelch	335..379	CDD:128874	11/45 (24%)
		KELCH repeat	369..416	CDD:276965	12/46 (26%)
		Kelch	382..430	CDD:128874	13/48 (27%)
		KELCH repeat	420..463	CDD:276965	15/49 (31%)
		Kelch	433..476	CDD:128874	14/48 (29%)
		KELCH repeat	467..510	CDD:276965	13/42 (31%)
		Kelch	478..523	CDD:128874	11/44 (25%)
		KELCH repeat	514..558	CDD:276965	13/48 (27%)
		Kelch_1	514..556	CDD:279660	13/46 (28%)
		KELCH repeat	561..606	CDD:276965	9/53 (17%)
		Kelch	572..616	CDD:128874	9/52 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I4252
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
	4	3.960