DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and klhl31

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_001003727.1	Gene:	klhl31 / 407079	ZFINID:	ZDB-GENE-030131-2052	Length:	635	Species:	Danio rerio

Alignment Length:	611	Identity:	148/611 - (24%)
Similarity:	253/611 - (41%)	Gaps:	86/611 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKD----EINLYG 94
            ||.||..:|.:..|.|:|:..:...|..|:||:|:.|:|...|.        |||    :|.|..
Zfish    60 LLEGLGHMRQDSFLCDLTVATKSKSFDVHKVVMASCSEYIQNML--------RKDPSLKKIELSD 116

  Fly    95 IKARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMAD 159
            :....:.::|.|.|:..|.|:...|...::||..:|:..::..|:.||..:..:|||:.:..:||
Zfish   117 LSPVGLATVITYAYSGKLTLSLYTIGSTISAALLLQIHTLVKMCSDFLMRETSVENCMYVVNIAD 181

  Fly   160 IYGIMDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQ 224
            .|.:.:..|.|.::|..:|.||:....|.::..:|:...|:.:               |..:..:
Zfish   182 TYNLKETKEAAQKFMRENFIEFSEMEQFLKLTYEQINEFLTDD---------------SLQLPSE 231

  Fly   225 LNESALGDLLRLIKWQHISYKSV----DELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLL--- 282
            |....:.     :||.....|.:    |.|.|:.......:.|........|:.|:...|.|
Zfish   232 LTAFQIA-----VKWLDFDEKRLKYAPDLLSNIRFGTITPQDLVSHVQNVPRMMQDAECHRLLVD 291

  Fly   283 ---NGVVSLKDQSLPQGPTNMRGMELCLLKIGG---FEWNGLTNVIMCFSPKKMNWYELTAIP-- 339
               ..::..:...|....|.:||....||.:||   .....|:..|: :..:...|.:||.:|
Zfish   292 AMNYHLLPFQQNILQSRRTKVRGGLRVLLTVGGRPALTEKSLSKDIL-YRDEDNVWNKLTEMPAK 355

  Fly   340 HIDQCNFGTAVLNNKLFIVGG------------AYDVFLKEYIHPFGFCYCPLRNTWMTIAPIQQ 392
            ..:||   .|||:..|::.||            |...|.:         |.|..|||:.:|.:.|
Zfish   356 SFNQC---VAVLDGFLYVAGGEDQNDARNQAKHAVSNFSR---------YDPRFNTWIHLANMIQ 408

  Fly   393 DRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVG 457
            .|..||||..... |:||||...|..:      ::||.|..:.|.|.....::..|..||..|:.
Zfish   409 KRTHFSLNTFNGL-LFAVGGRNSDGCQ------ASVECYVPSSNQWQMKAPMEVPRCCHASSVID 466

  Fly   458 DKLYISGGVHLANILA-SMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWHESLTEWR 521
            .|:.:||| ::.|..: ::..:|..|:.||:..|:.:|...|..|.|.:|.|..||........|
Zfish   467 GKILVSGG-YINNAYSRAVCSYDPSTDSWQDKNSLSSPRGWHCSVTVGDRAYVLGGSQLGGRGER 530

  Fly   522 VLVEHIYAYDIETNTWSVETKIPAPKFYTGVTAMGRTIFFVGGLDSTESIDRASAETMAYDLDTK 586
            |.|..:..|:..:..||....:.......|...:...|:.:||.:..|...:...:  .|:.|..
Zfish   531 VDVLPVECYNPHSGQWSYVAPLLTGVSTAGAATLNNKIYLLGGWNEIEKKYKKCIQ--VYNPDLN 593

  Fly   587 EWWHEKDSWDSPNDVWESTCVAIYVP 612
            ||..:.   :.|......:|..:.:|
Zfish   594 EWTEDD---ELPEATVGISCCVVTIP 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	28/107 (26%)
		PHA03098	46..588	CDD:222983	138/573 (24%)
		BACK	151..249	CDD:285009	18/101 (18%)
		KELCH repeat	344..390	CDD:276965	15/57 (26%)
		KELCH repeat	394..444	CDD:276965	16/49 (33%)
		Kelch	406..458	CDD:128874	15/51 (29%)
		Kelch_1	448..492	CDD:279660	14/44 (32%)
		KELCH repeat	448..492	CDD:276965	14/44 (32%)
		Kelch_1	494..539	CDD:279660	13/44 (30%)
		KELCH repeat	495..539	CDD:276965	12/43 (28%)
klhl31	NP_001003727.1	BTB	64..164	CDD:279045	28/107 (26%)
		PHA03098	74..614	CDD:222983	141/593 (24%)
		BACK	173..274	CDD:285009	22/120 (18%)
		Kelch 1	318..366		15/51 (29%)
		KELCH repeat	357..406	CDD:276965	16/60 (27%)
		Kelch 2	367..420		17/61 (28%)
		Kelch	368..420	CDD:128874	17/60 (28%)
		KELCH repeat	410..454	CDD:276965	16/50 (32%)
		Kelch	421..467	CDD:128874	15/52 (29%)
		Kelch 3	421..467		15/52 (29%)
		Kelch_1	456..501	CDD:279660	14/45 (31%)
		KELCH repeat	457..502	CDD:276965	14/45 (31%)
		Kelch 4	469..514		13/45 (29%)
		KELCH repeat	504..554	CDD:276965	13/49 (27%)
		Kelch 5	516..566		10/49 (20%)
		Kelch	517..566	CDD:128874	10/48 (21%)
		KELCH repeat	556..603	CDD:276965	9/51 (18%)
		Kelch_1	559..597	CDD:279660	9/39 (23%)
		Kelch 6	567..615		10/52 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45416
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45632
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.030