DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and klhl10

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_001015100.2	Gene:	klhl10 / 3354863	FlyBaseID:	FBgn0040038	Length:	767	Species:	Drosophila melanogaster

Alignment Length:	657	Identity:	153/657 - (23%)
Similarity:	256/657 - (38%)	Gaps:	171/657 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SPEEETL-----------------------LRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAAS 69
            |||::||                       |..||:||.:..|.|..:.|.|..|..||.::.:.
  Fly    39 SPEDKTLGIGRKTILNAHTKSLAPIVSDEALNTLNELREQNLLCDAQISVGEDVFNVHRAIMCSC 103

  Fly    70 SDYFCAMF----------ADCAMIESRKDEINLYGIKARAMGSIIDYIYTSMLELNYDNIEEILA 124
            |.||.|.|          .|.:..:...:.|::.|:.:..|..:|.|.|.....::..|:.|:|.
  Fly   104 SSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLI 168

  Fly   125 AATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEEFATTS-DFK 188
            .|.:|.:..::.:|..:||..:..|||::|.|.|....:.||..:|..|...:|.|.|..: |..
  Fly   169 CADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDIL 233

  Fly   189 EMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQLNESALGDLLRLIKWQHISYKSVDELRNM 253
            :|..:....|:|.: .::..|:|.|..:|                   :||       :|  ||
  Fly   234 DMSAEDFYSIISDD-ELNTREEDHVWKLC-------------------VKW-------ID--RN- 268

  Fly   254 NCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGV--------------------------------- 285
                        |.|     ::.|:.||:.||
  Fly   269 ------------PES-----RKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDT 316

  Fly   286 ----------------VSLKDQSLPQGPTNMRGMELCLLKIGGFEWNGLTN--VIMCFSPKKMNW 332
                            ::....::|:.|..:      :..|||  |:|.|:  .|..:..:...|
  Fly   317 FKFMYDLDFLNPQADELTTPPLAMPRLPHEV------IFAIGG--WSGGTSKGCIETYDTRADRW 373

  Fly   333 YELTA-IPHIDQCNFGTAVLNNKLFIVGGAYDVFLKEYIHPFGFC--YCPLRNTWMTIAPIQQDR 394
            ..:.| .|...:...|||||..|:|.:|| ||..  ||   |..|  :..::..|..|||:...|
  Fly   374 VTINAEDPAGPRAYHGTAVLGFKIFSIGG-YDGV--EY---FNTCRVFDAVKKKWNEIAPMHCRR 432

  Fly   395 CRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDK 459
            |..|:..:... :||:|| .|..|.     ::.||||:...|.|:.:|.:...||..:...:.::
  Fly   433 CYVSVTELNGM-IYAIGG-YDGHNR-----LNTVERYNPRTNQWSVIPPMNMQRSDASACTLQER 490

  Fly   460 LYISGGVHLANILASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWHESL---TEWR 521
            :|.:||.:....|.|...:|..|.||..:.:|.........||..|::|..||::.:.   |..|
  Fly   491 IYATGGFNGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGER 555

  Fly   522 VLVEHIYAYDIETNTWSVETKIPAPKFYTGVTAMGRTIFFVGGLDSTESIDRASAETMAYDLDTK 586
                    :|.:|.||....::...:...|:..:...||.:||.:...:|    :.|..|..:|.
  Fly   556 --------FDPDTQTWHFIREMNHSRSNFGLEIIDDMIFAIGGFNGVSTI----SHTECYVAETD 608

  Fly   587 EWWHEKD 593
            ||....|
  Fly   609 EWMEATD 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	29/113 (26%)
		PHA03098	46..588	CDD:222983	140/609 (23%)
		BACK	151..249	CDD:285009	21/98 (21%)
		KELCH repeat	344..390	CDD:276965	18/47 (38%)
		KELCH repeat	394..444	CDD:276965	16/49 (33%)
		Kelch	406..458	CDD:128874	15/51 (29%)
		Kelch_1	448..492	CDD:279660	11/43 (26%)
		KELCH repeat	448..492	CDD:276965	11/43 (26%)
		Kelch_1	494..539	CDD:279660	12/47 (26%)
		KELCH repeat	495..539	CDD:276965	12/46 (26%)
klhl10	NP_001015100.2	BTB	72..186	CDD:279045	29/113 (26%)
		PHA03098	86..610	CDD:222983	138/603 (23%)
		BACK	195..298	CDD:285009	31/149 (21%)
		Kelch	347..394	CDD:128874	14/54 (26%)
		KELCH repeat	385..428	CDD:276965	18/48 (38%)
		Kelch	396..442	CDD:128874	17/51 (33%)
		Kelch_1	431..476	CDD:279660	16/51 (31%)
		KELCH repeat	432..475	CDD:276965	16/49 (33%)
		KELCH repeat	479..523	CDD:276965	11/43 (26%)
		Kelch	490..536	CDD:128874	12/45 (27%)
		Kelch_1	525..570	CDD:279660	12/52 (23%)
		KELCH repeat	526..571	CDD:276965	12/52 (23%)
		Kelch_1	573..617	CDD:279660	12/47 (26%)
		KELCH repeat	573..617	CDD:276965	12/47 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1072
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
	4	3.860