DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and klhl11

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_956077.1	Gene:	klhl11 / 327313	ZFINID:	ZDB-GENE-030131-5524	Length:	679	Species:	Danio rerio

Alignment Length:	675	Identity:	144/675 - (21%)
Similarity:	259/675 - (38%)	Gaps:	167/675 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SAAAKIPV----NPVSPEEETLLRG------------------LNKLRNEEK----LTDVTL--- 52
            :|||..|.    |..||...:.|.|                  |::.:||::    ..||||
Zfish     2 AAAAPNPEDASRNSSSPSTPSALMGDGESEEAEEFASATHCSELSRRQNEQRKLGLFCDVTLAFS 66

  Fly    53 ----IVEEHRFKAHRVVLAASSDYFCAM----FADCAMIESRKDEINLY----GIKARAMGSIID 105
                ......|.|||.||||::|||..:    |::..   :|:.|:..:    |:....:.|:|.
Zfish    67 SAPGAANNFEFNAHRSVLAAATDYFTPLLGGQFSESV---TRRVEMKEWSSEAGLDQETVESVIQ 128

  Fly   106 YIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLSERA 170
            ::||..:.::..|:.|:|..|....:.::.|.|..||..|:.:.||:||..:|.:|.:..|:.||
Zfish   129 FMYTGEIRVSTANVHEVLELADRFLLVQLKDFCGEFLKRKLSLGNCVAIHSLAHMYTLDQLALRA 193

  Fly   171 YRYMCAHFEEFATTSDFKEMKVDQLRFILS-SNYPIDVAEQDLVRLVCSFAIEQQLNESALGDLL 234
            ...:..:|.:.....:|..:....:|..|| :...:|                   :|..|.|
Zfish   194 VDMIRRNFHKVIQDEEFYTLPFRLVRDWLSDAEITVD-------------------SEEVLFD-- 237

  Fly   235 RLIKW------QHISYKSVDELRNMNCSLDKGKQLP-LPTSYYNR-IKQEHM------------- 278
            .::||      :.:.|  .:||..:       .:|| :..:|..| :|.|.:
Zfish   238 AVVKWVQKNSEERVKY--FEELFRL-------LRLPQIKPTYLTRVVKNEPLVAQNAACLQLVSE 293

  Fly   279 ---GHLLNGVVSLKDQSLPQGPTNM-------------RGMELCLLKIGGFEWNG--LTNVIMCF 325
               ||      :::.::|....|..             :.|:: ::.:||....|  |:..:..|
Zfish   294 AVEGH------AIRFENLKSADTEFWASYMATFQPRFGQNMDV-IMVVGGVSEGGDYLSECVGYF 351

  Fly   326 SPKKMNWYELTAIPHIDQCNFGTAV--LNNKLFIVGGAYDVFLKEYIHPFGFCYCPLRNTWMTIA 388
            ..:. .|..|   |||.....|.|:  .:..:::.|.....|.|....     |.|.||||..::
Zfish   352 VYED-RWVNL---PHIHNHLDGHAIAATDTHVYVAGSMEPGFAKTVER-----YNPNRNTWEQVS 407

  Fly   389 PIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAG 453
            .:...:..|.|..: ...||::||     :........:|..|:..::.|..:.|..:.......
Zfish   408 NLTTRKHSFGLTCI-KNILYSIGG-----HGNFSPGFKDVSVYEPDQDKWHNLESAPKILRDVKA 466

  Fly   454 VVVGDK-LYISGGV--------HLANILASMWVFDTKTEVWQELASMP---TPCCDHVLVAVDNR 506
            :.|.|: :|::...        .|..:...   :||.:..|||:.|:|   ..|...:.||..|.
Zfish   467 ISVEDRYVYVTARTPVDTDSDDGLKTVTTR---YDTDSRQWQEVDSLPLIDNYCLFQMAVASTNF 528

  Fly   507 IYACGGWHESLTEWR--VLVEHIYAY---DIETNTWSVETKIPAPKFYTG--VTAMGRTIFFVGG 564
            .:......:|.|..|  |..:.|.|.   ||      :|:..|......|  :..:|..:|.:||
Zfish   529 YHTASCCPKSYTNVRDDVARQKISARISDDI------LESLPPEVTSIEGAAICYLGDDVFVIGG 587

  Fly   565 LDSTESIDRA-SAETMAYDLDTKEW 588
            ..:::.:|:. ..|...|..:.|.|
Zfish   588 WKNSDDVDKQYRKEAYRYCAERKRW 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	32/122 (26%)
		PHA03098	46..588	CDD:222983	131/622 (21%)
		BACK	151..249	CDD:285009	20/104 (19%)
		KELCH repeat	344..390	CDD:276965	11/47 (23%)
		KELCH repeat	394..444	CDD:276965	9/49 (18%)
		Kelch	406..458	CDD:128874	9/51 (18%)
		Kelch_1	448..492	CDD:279660	10/52 (19%)
		KELCH repeat	448..492	CDD:276965	10/52 (19%)
		Kelch_1	494..539	CDD:279660	12/49 (24%)
		KELCH repeat	495..539	CDD:276965	12/48 (25%)
klhl11	NP_956077.1	BTB	50..166	CDD:279045	32/118 (27%)
		PHA03098	54..541	CDD:222983	113/544 (21%)
		BACK	174..276	CDD:285009	26/131 (20%)
		Kelch_1	369..410	CDD:279660	11/45 (24%)
		KELCH repeat	369..409	CDD:276965	11/44 (25%)
		Kelch_1	412..456	CDD:279660	9/49 (18%)
		KELCH repeat	413..458	CDD:276965	10/50 (20%)
		KELCH repeat	461..511	CDD:276965	10/52 (19%)
		KELCH repeat	572..618	CDD:276965	10/41 (24%)
		Kelch	582..628	CDD:128874	8/31 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900