DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and klhl13

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	XP_005165329.1	Gene:	klhl13 / 323951	ZFINID:	ZDB-GENE-030131-2671	Length:	682	Species:	Danio rerio

Alignment Length:	600	Identity:	174/600 - (28%)
Similarity:	274/600 - (45%)	Gaps:	81/600 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LLRGLNKLRNEEKLTDVTLIV--EEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIK 96
            :|:|.::||.|..|.||||:.  .:..|..||.::|:|||||.|||.. .|.|.....|.|:|:.
Zfish   103 VLQGFDQLRIEGLLCDVTLVAGDGDEAFPVHRAMMASSSDYFKAMFTG-GMKEQDLMCIKLHGVN 166

  Fly    97 ARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIY 161
            ...:..|||:|||:.|.||.:|:::.|.||:.:|:..|:|.|.:||.:.:.::||:.:..:|:.|
Zfish   167 RIGLKKIIDFIYTAKLSLNMENLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTY 231

  Fly   162 GIMDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQLN 226
            .:.::.:....::..:|.....|.:|.::..::|.|:||||.....:|.||.:..|.:...::..
Zfish   232 NLTEVDKYVNNFILKNFPSLLGTGEFVKLPFERLAFVLSSNSLKHCSELDLFKSACRWLRYEEGR 296

  Fly   227 ESALGDLLRLIKWQHIS-------YKSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNG 284
            ......|:|.|::..:|       .::||.:|..|..::    |.|..|.|     :.|.::
Zfish   297 MEYAAKLMRNIRFPLMSPTELINHVQTVDFMRTDNTCVN----LLLEASNY-----QMMPYM--- 349

  Fly   285 VVSLKDQSLPQGP-TNMRGMELCLLKIGGFEWNGL--TNVIMCFSPKKMNWYELTAIPHIDQCNF 346
                  |.:.|.. |.:|.....|:.:||.....|  :..:..|..|...|   .|:..:|...:
Zfish   350 ------QPVMQSERTAIRSDNTHLVTLGGVLRQQLVVSKELRLFDEKAHEW---KALAPMDAPRY 405

  Fly   347 --GTAVLNNKLFIVGGA--YDVFLKEYIHPFGFCYCPLRNTWMTIAPIQQDRCRFSLNAVGTQHL 407
              |.||:.|.|::|||.  ||...|..:... |.|.|..|.|:.:|.:.:.|..|.|:|: ..:|
Zfish   406 QHGIAVIGNFLYVVGGQSNYDTKGKTAVDTV-FRYDPRYNKWIQVACLNEKRTFFHLSAL-KGYL 468

  Fly   408 YAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHLANIL 472
            |||||      ..|...::.||.|:...|.|||:..:.|....|||.|.|..:|||||:......
Zfish   469 YAVGG------RNAAGELATVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGYMYISGGITHDTFQ 527

  Fly   473 ASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWHESLTEWRVLVEHIYAYDIETNTW 537
            ..:..||...:.|.:.|.|.|....|.:..|.:|:|..||.|...|.         .||   :..
Zfish   528 KELMCFDPDADKWTQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTS---------DYD---DVL 580

  Fly   538 SVETKIPAPKFYTGVTAMGR------------TIFFVGGLDSTESIDRASAE-TMAYDLDTKEWW 589
            |.|...||...:|.:.||.|            .|:.|||....   :|...| ...||
Zfish   581 SCEYYSPALDLWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWN---NRCMVEIVQKYD------- 635

  Fly   590 HEKDSWDSPNDVWES 604
            .|||.|....|:.||
Zfish   636 PEKDEWHKVFDLPES 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	42/105 (40%)
		PHA03098	46..588	CDD:222983	162/570 (28%)
		BACK	151..249	CDD:285009	21/104 (20%)
		KELCH repeat	344..390	CDD:276965	17/49 (35%)
		KELCH repeat	394..444	CDD:276965	18/49 (37%)
		Kelch	406..458	CDD:128874	19/51 (37%)
		Kelch_1	448..492	CDD:279660	14/43 (33%)
		KELCH repeat	448..492	CDD:276965	14/43 (33%)
		Kelch_1	494..539	CDD:279660	10/44 (23%)
		KELCH repeat	495..539	CDD:276965	10/43 (23%)
klhl13	XP_005165329.1	BTB	107..213	CDD:279045	43/106 (41%)
		PHA03098	117..660	CDD:222983	167/585 (29%)
		BACK	221..322	CDD:285009	20/100 (20%)
		Kelch_1	403..453	CDD:279660	17/50 (34%)
		KELCH repeat	404..452	CDD:276965	17/48 (35%)
		KELCH repeat	456..500	CDD:276965	18/50 (36%)
		Kelch	468..513	CDD:128874	19/50 (38%)
		Kelch_1	502..547	CDD:279660	14/44 (32%)
		KELCH repeat	503..548	CDD:276965	15/44 (34%)
		KELCH repeat	550..599	CDD:276965	16/60 (27%)
		Kelch	561..612	CDD:128874	16/62 (26%)
		KELCH repeat	602..649	CDD:276965	13/56 (23%)
		Kelch_1	603..644	CDD:279660	12/50 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45416
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45632
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.030