DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1812 and Klhl31

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_001101640.1	Gene:	Klhl31 / 315833	RGDID:	1560540	Length:	634	Species:	Rattus norvegicus

Alignment Length:	601	Identity:	155/601 - (25%)
Similarity:	265/601 - (44%)	Gaps:	64/601 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKAR 98
            ||.||:|:|.|..|.|:.:..:...|..|:.|:|:.|:||..:..:    :.....::|..|...
  Rat    59 LLEGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKN----DPSTKRVDLNDIAPL 119

  Fly    99 AMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGI 163
            .:.::|.|.||..|.|:...|..|::||.::|:..::..|:.||..:|.:|||:.:..||:.|.:
  Rat   120 GLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMYVVNMAETYCL 184

  Fly   164 MDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAI------- 221
            .:....|.:::..:|.|||.:..|.::..:|:..:|..:      :..|...:.:|.|
  Rat   185 KNAKATAQKFIRDNFIEFADSEQFMKLTFEQINELLIDD------DLQLPSELVAFQIAMKWIEF 243

  Fly   222 -EQQLNESALGDLLRLIKWQHISYKS----VDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHL 281
             ::::..:|  |||..|::..||.:.    |..:..|....|..|.|....:|          ||
  Rat   244 DQKRVKHAA--DLLSNIRFGTISAQDLVNYVQTVPRMMQDADCHKLLVDAMNY----------HL 296

  Fly   282 LNGVVSLKDQSLPQGPTNMRGMELCLLKIGGFEWNGLTNVIM----CFSPKKMNWYELTAIP--H 340
            |    .....:|....|.:||....|:.:||..  |||...:    .:...:..|.:||.:|  .
  Rat   297 L----PYHQNTLQSRRTRIRGGCRVLITVGGRP--GLTEKSLSRDVLYRDPENGWSKLTEMPAKS 355

  Fly   341 IDQCNFGTAVLNNKLFIVGG--AYDVFLKEYIHPFGFC-YCPLRNTWMTIAPIQQDRCRFSLNAV 402
            .:||   .||::..|::.||  ..|...:.......|| |.|..|||:.:..:.|.|..||| :|
  Rat   356 FNQC---VAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLGSMNQKRTHFSL-SV 416

  Fly   403 GTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVH 467
            ....||||||      ..|...::::|.|..:.|.|.....|:..|..||..|...::.::||..
  Rat   417 FNGLLYAVGG------RNAEGSLASLECYVPSTNQWQPKAPLEVARCCHASAVADGRVIVTGGYI 475

  Fly   468 LANILASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWHESLTEWRVLVEHIYAYDI 532
            .:....|:..:|...:.||||..:.||...|..||:.:|:|..||........||.|..:.::..
  Rat   476 GSAYSRSVCAYDPALDAWQELPGLSTPRGWHCSVALGDRVYVMGGSQLGPRGERVDVLTVESFSP 540

  Fly   533 ETNTWSVETKIPAPKFYTGVTAMGRTIFFVGGLDSTESIDRASAETMAYDLDTKEWWHEKDSWDS 597
            ....||....:|......||:|:....:.|||.:..|...:...:....:|:.   |.|.|  :.
  Rat   541 VARQWSFVAPLPVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFNPELNE---WMEDD--EL 600

  Fly   598 PNDVWESTCVAIYVPN 613
            |......:|..:.:||
  Rat   601 PEATVGVSCCTLAMPN 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	27/103 (26%)
		PHA03098	46..588	CDD:222983	141/562 (25%)
		BACK	151..249	CDD:285009	23/109 (21%)
		KELCH repeat	344..390	CDD:276965	14/48 (29%)
		KELCH repeat	394..444	CDD:276965	16/49 (33%)
		Kelch	406..458	CDD:128874	16/51 (31%)
		Kelch_1	448..492	CDD:279660	12/43 (28%)
		KELCH repeat	448..492	CDD:276965	12/43 (28%)
		Kelch_1	494..539	CDD:279660	12/44 (27%)
		KELCH repeat	495..539	CDD:276965	11/43 (26%)
Klhl31	NP_001101640.1	BTB	63..164	CDD:279045	28/104 (27%)
		PHA03098	73..601	CDD:222983	143/570 (25%)
		BACK	172..273	CDD:285009	22/108 (20%)
		KELCH repeat	356..405	CDD:276965	15/51 (29%)
		Kelch	367..419	CDD:128874	17/52 (33%)
		KELCH repeat	409..453	CDD:276965	16/50 (32%)
		Kelch	420..466	CDD:128874	16/51 (31%)
		KELCH repeat	456..501	CDD:276965	12/44 (27%)
		Kelch	467..513	CDD:128874	13/45 (29%)
		Kelch_1	502..552	CDD:279660	13/49 (27%)
		KELCH repeat	503..553	CDD:276965	12/49 (24%)
		KELCH repeat	555..602	CDD:276965	11/51 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45416
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45632
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030