DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and Klhl15

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_001101491.1	Gene:	Klhl15 / 314111	RGDID:	1563101	Length:	604	Species:	Rattus norvegicus

Alignment Length:	616	Identity:	158/616 - (25%)
Similarity:	278/616 - (45%)	Gaps:	111/616 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SPEEETLLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMF-ADCAMIESRKDEIN 91
            |..:.::..|...|..|..|.||||::|:|:|:||:.:||..||||..|| ||  |.|..:|:|:
  Rat    11 SIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTAD--MRERDQDKIH 73

  Fly    92 LYGIKARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAG 156
            |.|:.|.....::.::|...:||:.:.:.|||.||.:||:.||:..|..||.|||.:|||..|..
  Rat    74 LKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMR 138

  Fly   157 MADIYG--IMDLSERAYRYMCAHFEEFATTSDF-KEMKVDQLRFILSSNYPIDVAEQDLVRLVCS 218
            :.|.:|  |..:.|:...::..:|....:..|| ..:..::|...|.:::.....|.:|...|.|
  Rat   139 LLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQS 203

  Fly   219 FAIEQQLNESALGDLLRLIKWQHISYKSVDE----------LRNMNCSLDKGKQLPLPTSYYNRI 273
            :....:........:::.|::..::..||.|          .|.:...:|:.      .:|:..:
  Rat   204 WLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQA------LNYFQNV 262

  Fly   274 KQEHMGHLLNG-VVSLKDQSLPQGPTNMRGMELCLLKIGGFEWNGLTNVIMCFSPKKMNWYELTA 337
            .|:.:..:.:. :.|.|.|:     |..|||      ||    :.:.|..:....|...|:||..
  Rat   263 HQQPLLDMKSSRIRSAKPQT-----TVFRGM------IG----HSMVNSKILLLKKPRVWWELEG 312

  Fly   338 --IPHIDQCNFGTAVLNNKLFIVGGAYDVFLKEYIHPFG--------FCYCPLRNTWMTIAPIQQ 392
              :|....|   .|::||.:|::||       |.:.|.|        |.|.|.:|:|:.:|.:..
  Rat   313 PQVPLRPDC---LAIVNNFVFLLGG-------EELGPDGEFHASSKVFRYDPRQNSWLRMADMSV 367

  Fly   393 DRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVG 457
            .|..|::..:| :.:|||.|...|:.      ..:.|||||..:.|.::.....|:..|.|.|:.
  Rat   368 PRSEFAVGVIG-KFIYAVAGRTRDET------FYSTERYDITNDKWEFVDPYPVNKYGHEGTVLN 425

  Fly   458 DKLYISGGVHLANILASMWVFDTK---------------TEVWQELASMPTPCCDHVLVAVDNRI 507
            :||:|:||:..::....:.|||..               |..|:..:.|....|.|.:::.:.::
  Rat   426 NKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKL 490

  Fly   508 YACGGWHESL-----------TEWRVLVEHIYAYDIETNTWSVETKIPAPKFYTGVTAMGRTIFF 561
            |..||....|           ||         .|:.:|:.|::...:|..:...|||.:.:.|..
  Rat   491 YVFGGVCVILRASFESQGCPSTE---------VYNPDTDQWTILASMPIGRSGHGVTVLDKQIMV 546

  Fly   562 VGGL----DSTESIDRASAETMAYDLDTKEW 588
            :|||    ..::||       :.:|.|..:|
  Rat   547 LGGLCYNGHYSDSI-------LTFDPDENKW 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	42/104 (40%)
		PHA03098	46..588	CDD:222983	153/596 (26%)
		BACK	151..249	CDD:285009	18/100 (18%)
		KELCH repeat	344..390	CDD:276965	16/53 (30%)
		KELCH repeat	394..444	CDD:276965	14/49 (29%)
		Kelch	406..458	CDD:128874	15/51 (29%)
		Kelch_1	448..492	CDD:279660	13/58 (22%)
		KELCH repeat	448..492	CDD:276965	13/58 (22%)
		Kelch_1	494..539	CDD:279660	11/55 (20%)
		KELCH repeat	495..539	CDD:276965	11/54 (20%)
Klhl15	NP_001101491.1	BTB_POZ_KLHL15	1..137	CDD:349553	52/127 (41%)
		PHA03098	33..576	CDD:222983	152/594 (26%)
		BACK_KLHL15	128..235	CDD:350529	21/106 (20%)
		KELCH repeat	321..365	CDD:276965	16/53 (30%)
		Kelch 1	328..379		15/58 (26%)
		KELCH repeat	369..412	CDD:276965	14/49 (29%)
		Kelch 2	381..426		15/50 (30%)
		KELCH repeat	417..474	CDD:276965	13/56 (23%)
		Kelch 3	428..473		9/44 (20%)
		KELCH repeat	478..529	CDD:276965	11/59 (19%)
		Kelch 4	489..542		13/61 (21%)
		KELCH repeat	532..572	CDD:276965	12/46 (26%)
		Kelch 5	544..590		9/34 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45632
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020