DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and Klhl22

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	XP_006248761.1	Gene:	Klhl22 / 303792	RGDID:	1306288	Length:	720	Species:	Rattus norvegicus

Alignment Length:	587	Identity:	168/587 - (28%)
Similarity:	284/587 - (48%)	Gaps:	68/587 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ETLLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIK 96
            :.|||||..||:...|.||.|:||....:|||::||||.|||..|||. .:.|..::|:.::|:.
  Rat   120 QALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAG-GLKEMEQEEVLIHGVS 183

  Fly    97 ARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIY 161
            ..||..|:.:||||.|||:..|::|.|.||..:|:.|:|..|..||.:.::.||.|.:..:|:::
  Rat   184 YNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELF 248

  Fly   162 GIMDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLV---RLVCSFAIEQ 223
            .:..|:::...|:..:|..|:.|..::::.::::..:|||| .::|:.:..|   .|:..:::||
  Rat   249 DLNRLTQQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSN-RLEVSCETEVYEGALLYHYSMEQ 312

  Fly   224 -QLNESALGDLLRLIKWQHISYKSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVVS 287
             |.::.:|.:..:|::.........:.|:.::..|.       |:...:.:....|.|
  Rat   313 VQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLG-------PSPLRDTVASALMYH------- 363

  Fly   288 LKDQSLP---QGP-TNMRGMELCLLKIGGFEWNGLTNVIMCFSPKKMN-----WYELTAIPHIDQ 343
             :::||.   ||| |.:|....|::..||.  :...:.|:....|.:|     |...||......
  Rat   364 -RNESLQPSLQGPHTELRSDFQCVVGFGGI--HSTPSTILSDQAKYLNPLLGEWKHFTASLAPRM 425

  Fly   344 CNFGTAVLNNKLFIVGGAYDVFLKEYIHPFGF-----C--YCPLRNTWMTIAPIQQDRCRFSLNA 401
            .|.|.|||||.::::||..:|        .||     |  |.|..|.|..|..:||:.....:..
  Rat   426 SNQGIAVLNNFVYLIGGDNNV--------QGFRAESRCWRYDPRHNRWFQIQSLQQEHADLCVCV 482

  Fly   402 VGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGV 466
            || :::|||.| .|..|.     :|.|||||.|.|.|.|:..|::....|||..:..|:||:.|.
  Rat   483 VG-KYIYAVAG-RDYHNN-----LSAVERYDPATNSWEYVAPLKKEVYAHAGTTLQGKMYITCGR 540

  Fly   467 HLANILASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWHESLTEWRVLVEHIYAYD 531
            ...:.|.....:|..:..|..||..|.....|.:.|:.::::..||.:.. ..:|..|..:..|.
  Rat   541 RGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMAALLDKLFVIGGSNND-AGYRRDVHQVACYS 604

  Fly   532 IETNTWSVETKIPAPKFYTGVTAMGRTIFFVGGLDSTESIDRAS--AETMAYDLDTKEWWHEKDS 594
            ..:..||....:||.....|:..:...|:.:||    .|.:|.|  .....||:       |||.
  Rat   605 CTSRQWSSVCPLPAGHGEPGIAVLDNRIYVLGG----RSHNRGSRTGYVHIYDM-------EKDC 658

  Fly   595 WD 596
            |:
  Rat   659 WE 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	44/103 (43%)
		PHA03098	46..588	CDD:222983	157/563 (28%)
		BACK	151..249	CDD:285009	19/101 (19%)
		KELCH repeat	344..390	CDD:276965	18/52 (35%)
		KELCH repeat	394..444	CDD:276965	18/49 (37%)
		Kelch	406..458	CDD:128874	20/51 (39%)
		Kelch_1	448..492	CDD:279660	12/43 (28%)
		KELCH repeat	448..492	CDD:276965	12/43 (28%)
		Kelch_1	494..539	CDD:279660	8/44 (18%)
		KELCH repeat	495..539	CDD:276965	8/43 (19%)
Klhl22	XP_006248761.1	BTB	131..229	CDD:279045	41/98 (42%)
		PHA03098	138..678	CDD:222983	159/569 (28%)
		BACK	239..342	CDD:197943	20/103 (19%)
		KELCH repeat	380..421	CDD:276965	10/42 (24%)
		KELCH repeat	426..471	CDD:276965	18/52 (35%)
		Kelch	437..485	CDD:128874	15/56 (27%)
		KELCH repeat	475..519	CDD:276965	18/50 (36%)
		Kelch_1	476..519	CDD:279660	18/49 (37%)
		KELCH repeat	522..567	CDD:276965	12/44 (27%)
		Kelch	533..579	CDD:128874	12/45 (27%)
		KELCH repeat	569..617	CDD:276965	9/48 (19%)
		Kelch	580..630	CDD:128874	10/50 (20%)
		KELCH repeat	620..666	CDD:276965	13/52 (25%)
		Kelch	631..677	CDD:128874	12/41 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H23784
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45632
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020