DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and Klhl34

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	XP_228962.2	Gene:	Klhl34 / 302703	RGDID:	1560439	Length:	645	Species:	Rattus norvegicus

Alignment Length:	626	Identity:	172/626 - (27%)
Similarity:	256/626 - (40%)	Gaps:	106/626 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TLLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKA 97
            :||.|...||.|..|.||||..|...|.|||.:||.|||||.|:|..... |||...|:|:...|
  Rat    14 SLLTGYQALRAEGFLCDVTLEAEGSEFPAHRSLLACSSDYFRALFKSHTQ-ESRARVIHLHVPSA 77

  Fly    98 RAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYG 162
            ..:..::|:|||:.|.|:.|.:|:.|.||:::||.|.:..|..:|..::..|||...|.:|..:|
  Rat    78 AGLQRLLDFIYTAWLPLSMDTVEDTLEAASYLQVTEALGLCAHYLERQLTPENCCFTANVAARFG 142

  Fly   163 IMDLSERAYRYMCAHFEEF----ATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQ 223
            :......|...:..|..|.    |..|...|:....::.:|.:.....|||..|:||..:: ::|
  Rat   143 LARTLGAAEHCIVRHLGELLLMGAGPSGLLELNPISMKAVLGAPNVARVAETRLLRLALAW-LQQ 206

  Fly   224 QLNESALGDLLRLIKWQHISYKSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVVSL 288
            :.....|.....|:............||.|.    .|..|.|||...:.|.|     .||...:.
  Rat   207 EPTTQRLAHSSTLLGCIRFGLVPASVLRRMY----SGSGLILPTRIKSLIIQ-----ALNYHTAP 262

  Fly   289 KDQSLPQG-PTNMRGMELCLLKIGGF--------------------------------------- 313
            ..|.|.|| .|::|..:..:|.:||.
  Rat   263 SSQPLLQGEQTSVRSPQTRILLVGGLRARETVTEEIMVLPEVVRNRRPAPEPEEEEGEEEEEMEE 327

  Fly   314 --EWNGLTNVIMCFSPKKMNWYELTAIP-----HIDQCNFGTAVLNNKLFIVGGAY--------- 362
              ||. ||..::.|.....:|:.||.:|     | ..|..|     |.||::||..
  Rat   328 EKEWE-LTQDVVSFDVYNHSWHTLTQLPTPLLGH-SVCTIG-----NFLFVLGGESLSGSPSSSL 385

  Fly   363 ---DVFLKEYIHPFGFCYCPLRNTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRM 424
               ...:...:|.    |.|..:||..:..:::.|..|....|| :.|.||||:  ....|||
  Rat   386 ADGSRSVTALVHR----YDPRFHTWTEVPAMREARAYFWCGVVG-ESLLAVGGL--GTCGEAL-- 441

  Fly   425 ISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDK--LYISG-----GVHLANILASMWVFDTKT 482
             ::||.||:.::.|.....|......||| .|||.  :||||     |....:.|..|:......
  Rat   442 -ASVEMYDLRRDRWVAAGELPRAVHGHAG-AVGDHGVVYISGGKAGRGEGGTSSLRDMYSLSPGE 504

  Fly   483 EVWQELASMPTPCCDHVLVAVDNRIYACGGWHESLTEWRVLVEHIYAYDIETNTWSVETKIPAPK 547
            .||.:.|.|.|....|.|..:...::|..|.:|..:|       |..||..|:.|:....:|..:
  Rat   505 RVWSKRAPMGTARYGHYLAVLRGAVFAFLGRYEPFSE-------IERYDPSTDQWTRLRSLPYDR 562

  Fly   548 FYTGVTAMGRTIFFVGGLDSTESIDRASAETMAYDLDTKEW 588
            |..|:..:..|:..:|||...:|....:...:.||||...|
  Rat   563 FCYGLAVVEETVLLLGGLKWRDSRQVPTRNVVGYDLDLDRW 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	43/103 (42%)
		PHA03098	46..588	CDD:222983	165/611 (27%)
		BACK	151..249	CDD:285009	20/101 (20%)
		KELCH repeat	344..390	CDD:276965	12/57 (21%)
		KELCH repeat	394..444	CDD:276965	17/49 (35%)
		Kelch	406..458	CDD:128874	18/51 (35%)
		Kelch_1	448..492	CDD:279660	16/50 (32%)
		KELCH repeat	448..492	CDD:276965	16/50 (32%)
		Kelch_1	494..539	CDD:279660	11/44 (25%)
		KELCH repeat	495..539	CDD:276965	11/43 (26%)
Klhl34	XP_228962.2	BTB	19..122	CDD:279045	43/103 (42%)
		BTB	30..126	CDD:197585	40/96 (42%)
		BACK	131..235	CDD:197943	21/104 (20%)
		PLN02153	354..622	CDD:177814	74/274 (27%)
		KELCH repeat	359..412	CDD:276965	13/62 (21%)
		KELCH repeat	416..514	CDD:276965	34/104 (33%)
		Kelch	428..473	CDD:128874	18/50 (36%)
		Kelch_1	516..559	CDD:279660	11/49 (22%)
		KELCH repeat	517..560	CDD:276965	11/49 (22%)
		KELCH repeat	562..607	CDD:276965	12/42 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45632
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020