Protein Alignment CG1812 and Klhl2

DIOPT Version :10

• Sequence 1: NP_608397.1
• Gene: CG1812 / 33049
• FlyBaseID: FBgn0031119
• Length: 616
• Species: Drosophila melanogaster
• Sequence 2: NP_001406494.1
• Gene: Klhl2 / 290692
• RGDID: 1306388
• Length: 593
• Species: Rattus norvegicus
• Alignment Length: 629
• Identity: 165/629 - (26%)
• Similarity: 272/629 - (43%)
• Gaps: 113/629 - (17%)

  Fly     6 APAVTPAATATSAAAKIPVNPVSPEEETLL-----------RGLNKLRNEEKLTDVTLIVEEHRF 59
            :|.:.||.|.......:.....:||:...|           :.:|:||::..|.|||::.|:...
  Rat     3 SPPLPPACTKQGHQKPLDSKDENPEKHCPLTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEI 67

  Fly    60 KAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKARAMGSIIDYIYTSMLELNYDNIEEILA 124
            .||||||||.|.||.|||.. .|.|||...:.:..:....:..:|||:||:.:::..:|::.:|.
  Rat    68 PAHRVVLAACSPYFHAMFTG-EMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLP 131

  Fly   125 AATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEEFATTSDFKE 189
            ||..:|:::|...|..||.:::...|||.|...||::...||..:|..|...||.:...:.:|..
  Rat   132 AAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLN 196

  Fly   190 MKVDQLRFILSS-------------------NYPIDVAEQDLVRLVCSFAI-------------E 222
            :.::|:..::||                   |:..||.::.:.||:....:             |
  Rat   197 LGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEE 261

  Fly   223 QQL--NESALGD-LLRLIKW------QHISYKSVDELRNMNCSLDK-----GKQLP---LPTSYY 270
            :.|  |.||..| |:..:|:      |.:..|||........:|.|     |.|.|   .....|
  Rat   262 EALVKNSSACKDYLIEAMKYHLLPTEQRMLMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECY 326

  Fly   271 NRIKQEHMGHLLNGVVSLKDQSLPQGPTNMRGMELCLLKIGGFEWNGLTNVIMCFSPKKMNWYEL 335
            : .|:|..    :.|..|..:....|...|.|:   :..:|||..:.....:..:.|.|..|
  Rat   327 D-FKEERW----HQVAELPSRRCRAGMVYMAGL---VFAVGGFNGSLRVRTVDSYDPVKDQW--- 380

  Fly   336 TAIPHI--DQCNFGTAVLNNKLFIVGG-----------AYDVFLKEYIHPFGFCYCPLRNTWMTI 387
            |::.::  .:...|.||||..|:.|||           ||::               ..|.|..:
  Rat   381 TSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNI---------------KSNEWFHV 430

  Fly   388 APIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHA 452
            ||:...|....:..||.. |||||| .|..:.:.|   |.||.|:...|.|||:..:...|| .|
  Rat   431 APMNTRRSSVGVGVVGGL-LYAVGG-YDGASRQCL---STVECYNATANEWTYIAEMSTRRS-GA 489

  Fly   453 GV-VVGDKLYISGGVHLANILASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWHES 516
            || |:.:.||..||.....:..|:.|:|..|..|:::|.|.....:..:.||:..:|..||...|
  Rat   490 GVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGS 554

  Fly   517 LTEWRVLVEHIYAYDIETNTWSVETK-IPAPKFYTGVTAMGRTI 559
            ..     :..:..|:..|:.|:|.:. :...:.|.|||.:.:.:
  Rat   555 CN-----LASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB_POZ	33..151	CDD:453885	41/128 (32%)
		PHA03098	46..588	CDD:222983	155/578 (27%)
		KELCH repeat	344..390	CDD:276965	14/56 (25%)
		KELCH repeat	394..444	CDD:276965	19/49 (39%)
		KELCH repeat	448..492	CDD:276965	16/44 (36%)
		KELCH repeat	495..539	CDD:276965	9/43 (21%)
Klhl2	NP_001406494.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		6/25 (24%)
		BTB_POZ_KLHL2_Mayven	35..155	CDD:349647	40/120 (33%)
		PHA03098	56..573	CDD:222983	149/554 (27%)
		BACK_KLHL2_Mayven	153..282	CDD:350587	29/128 (23%)
		Kelch 1	308..353		10/49 (20%)
		KELCH repeat	343..386	CDD:276965	10/48 (21%)
		Kelch 2	354..400		11/51 (22%)
		KELCH repeat	390..434	CDD:276965	15/58 (26%)
		Kelch 3	402..447		12/59 (20%)
		Kelch 4	449..496		22/51 (43%)
		KELCH repeat	486..530	CDD:276965	16/44 (36%)
		Kelch 5	497..543		13/45 (29%)
		KELCH repeat	533..579	CDD:276965	10/50 (20%)
		Kelch 6	545..591		12/50 (24%)