DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1812 and KLHL34

DIOPT Version :9

Sequence 1:NP_608397.1 Gene:CG1812 / 33049 FlyBaseID:FBgn0031119 Length:616 Species:Drosophila melanogaster
Sequence 2:NP_695002.1 Gene:KLHL34 / 257240 HGNCID:26634 Length:644 Species:Homo sapiens


Alignment Length:629 Identity:171/629 - (27%)
Similarity:258/629 - (41%) Gaps:115/629 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 LLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKAR 98
            ||.|...||.|..|.||||..|...|.|||.:||.|||||.|:|..... |||...|:|:...|.
Human    15 LLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQ-ESRARVIHLHVPSAA 78

  Fly    99 AMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGI 163
            .:..::|:|||:.|.|:.|.:|:.|.||:::||.|.:..|..:|..::..|||...|.:|..:|:
Human    79 GLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARFGL 143

  Fly   164 MDLSERAYRYMCAHFEEF----ATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQ 224
            ....:.|.|.:.:|.:|.    |..:...|:....||.:|.:.....|.|..|:.|..:: :.|:
Human   144 AHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLALAW-LRQE 207

  Fly   225 LNESALGDLLRLIKWQHISYKSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVVSLK 289
            .....|.....|::.........|.||.:.    .|..|.||......|.|     .||...:..
Human   208 PTTERLAHCTELLERVRFGLVPADVLRRVY----SGSGLVLPARVKGLIIQ-----ALNYHTTPS 263

  Fly   290 DQSLPQG-PTNMRGMELCLLKIGG----------------------------------------F 313
            .|.|.|| .|::|..:..:|.:||                                        .
Human   264 RQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQVAAPEPEEEEEELEEEEEEE 328

  Fly   314 EWNGLTNVIMCFSPKKMNWYELTAIP-----HIDQCNFGTAVLNNKLFIVGGAYDVFLKEYIHPF 373
            ||. ||..::.|......|..||.:|     | ..|..|     |.||::||.         .|.
Human   329 EWE-LTQNVVAFDVYNHRWRSLTQLPTPLLGH-SVCTAG-----NFLFVLGGE---------SPS 377

  Fly   374 GFCYCPLR-----------------NTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEA 421
            |....||.                 :.|..:..:::.|..|...||| :.|.|||| |....|  
Human   378 GSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVG-ERLLAVGG-LGAGGE-- 438

  Fly   422 LRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDK--LYISG-----GVHLANILASMWVFD 479
              ::::||.||:.::.||...:|......||| .|||:  :||||     |...|:.|..::|..
Human   439 --VLASVEMYDLRRDRWTAAGALPRALHGHAG-AVGDRGVVYISGGKAGRGEGGASSLRDLYVLG 500

  Fly   480 TKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWHESLTEWRVLVEHIYAYDIETNTWSVETKIP 544
            .:.:||.:.|.|.|....|.:..:...::|..|.:|..:|       |..||...:.|:....:|
Human   501 PEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSE-------IERYDPGADQWTRLRPLP 558

  Fly   545 APKFYTGVTAMGRTIFFVGGLDSTESIDRASAETMAYDLDTKEW 588
            ..:|..|:..:..|...:|||...:|....:...:.||||...|
Human   559 YDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRW 602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1812NP_608397.1 BTB 38..142 CDD:279045 43/103 (42%)
PHA03098 46..588 CDD:222983 164/615 (27%)
BACK 151..249 CDD:285009 20/101 (20%)
KELCH repeat 344..390 CDD:276965 12/62 (19%)
KELCH repeat 394..444 CDD:276965 18/49 (37%)
Kelch 406..458 CDD:128874 18/51 (35%)
Kelch_1 448..492 CDD:279660 17/50 (34%)
KELCH repeat 448..492 CDD:276965 17/50 (34%)
Kelch_1 494..539 CDD:279660 9/44 (20%)
KELCH repeat 495..539 CDD:276965 9/43 (21%)
KLHL34NP_695002.1 BTB 19..126 CDD:306997 44/107 (41%)
BTB 29..603 CDD:333434 164/615 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 304..329 0/24 (0%)
Kelch 1 320..366 12/52 (23%)
KELCH repeat 358..411 CDD:276965 13/67 (19%)
Kelch 2 367..425 14/67 (21%)
KELCH repeat 415..513 CDD:276965 36/104 (35%)
Kelch 3 426..473 19/52 (37%)
Kelch 4 475..526 14/50 (28%)
KELCH repeat 516..559 CDD:276965 9/49 (18%)
Kelch 5 528..571 11/49 (22%)
KELCH repeat 561..606 CDD:276965 12/42 (29%)
Kelch 6 573..623 9/30 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D133095at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45632
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
44.020

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