Protein Alignment CG1812 and KLHL34

DIOPT Version :10

• Sequence 1: NP_608397.1
• Gene: CG1812 / 33049
• FlyBaseID: FBgn0031119
• Length: 616
• Species: Drosophila melanogaster
• Sequence 2: NP_695002.1
• Gene: KLHL34 / 257240
• HGNCID: 26634
• Length: 644
• Species: Homo sapiens
• Alignment Length: 629
• Identity: 171/629 - (27%)
• Similarity: 258/629 - (41%)
• Gaps: 115/629 - (18%)

  Fly    34 LLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKAR 98
            ||.|...||.|..|.||||..|...|.|||.:||.|||||.|:|..... |||...|:|:...|.
Human    15 LLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQ-ESRARVIHLHVPSAA 78

  Fly    99 AMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGI 163
            .:..::|:|||:.|.|:.|.:|:.|.||:::||.|.:..|..:|..::..|||...|.:|..:|:
Human    79 GLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARFGL 143

  Fly   164 MDLSERAYRYMCAHFEEF----ATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQ 224
            ....:.|.|.:.:|.:|.    |..:...|:....||.:|.:.....|.|..|:.|..:: :.|:
Human   144 AHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLALAW-LRQE 207

  Fly   225 LNESALGDLLRLIKWQHISYKSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVVSLK 289
            .....|.....|::.........|.||.:.    .|..|.||......|.|     .||...:..
Human   208 PTTERLAHCTELLERVRFGLVPADVLRRVY----SGSGLVLPARVKGLIIQ-----ALNYHTTPS 263

  Fly   290 DQSLPQG-PTNMRGMELCLLKIGG----------------------------------------F 313
            .|.|.|| .|::|..:..:|.:||                                        .
Human   264 RQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQVAAPEPEEEEEELEEEEEEE 328

  Fly   314 EWNGLTNVIMCFSPKKMNWYELTAIP-----HIDQCNFGTAVLNNKLFIVGGAYDVFLKEYIHPF 373
            ||. ||..::.|......|..||.:|     | ..|..|     |.||::||.         .|.
Human   329 EWE-LTQNVVAFDVYNHRWRSLTQLPTPLLGH-SVCTAG-----NFLFVLGGE---------SPS 377

  Fly   374 GFCYCPLR-----------------NTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEA 421
            |....||.                 :.|..:..:::.|..|...||| :.|.|||| |....|
Human   378 GSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVG-ERLLAVGG-LGAGGE-- 438

  Fly   422 LRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDK--LYISG-----GVHLANILASMWVFD 479
              ::::||.||:.::.||...:|......||| .|||:  :||||     |...|:.|..::|..
Human   439 --VLASVEMYDLRRDRWTAAGALPRALHGHAG-AVGDRGVVYISGGKAGRGEGGASSLRDLYVLG 500

  Fly   480 TKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWHESLTEWRVLVEHIYAYDIETNTWSVETKIP 544
            .:.:||.:.|.|.|....|.:..:...::|..|.:|..:|       |..||...:.|:....:|
Human   501 PEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSE-------IERYDPGADQWTRLRPLP 558

  Fly   545 APKFYTGVTAMGRTIFFVGGLDSTESIDRASAETMAYDLDTKEW 588
            ..:|..|:..:..|...:|||...:|....:...:.||||...|
Human   559 YDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRW 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB_POZ	33..151	CDD:453885	48/116 (41%)
		PHA03098	46..588	CDD:222983	164/615 (27%)
		KELCH repeat	344..390	CDD:276965	12/62 (19%)
		KELCH repeat	394..444	CDD:276965	18/49 (37%)
		KELCH repeat	448..492	CDD:276965	17/50 (34%)
		KELCH repeat	495..539	CDD:276965	9/43 (21%)
KLHL34	NP_695002.1	BTB_POZ_KLHL34	1..136	CDD:349573	50/121 (41%)
		BACK_KLHL34	126..233	CDD:350548	23/107 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	304..329		0/24 (0%)
		Kelch 1	320..366		12/52 (23%)
		NanM	333..578	CDD:442289	70/273 (26%)
		KELCH repeat	358..411	CDD:276965	13/67 (19%)
		Kelch 2	367..425		14/67 (21%)
		KELCH repeat	415..513	CDD:276965	36/104 (35%)
		Kelch 3	426..473		19/52 (37%)
		Kelch 4	475..526		14/50 (28%)
		KELCH repeat	516..559	CDD:276965	9/49 (18%)
		Kelch 5	528..571		11/49 (22%)
		KELCH repeat	561..606	CDD:276965	12/42 (29%)
		Kelch 6	573..623		9/30 (30%)