DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1812 and Klhdc7a

DIOPT Version :9

Sequence 1:NP_608397.1 Gene:CG1812 / 33049 FlyBaseID:FBgn0031119 Length:616 Species:Drosophila melanogaster
Sequence 2:NP_775603.2 Gene:Klhdc7a / 242721 MGIID:2444612 Length:773 Species:Mus musculus


Alignment Length:576 Identity:116/576 - (20%)
Similarity:170/576 - (29%) Gaps:244/576 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 AATPAPAVTPAATATSAAAKIPVNPVSPEEETLLRGLN-----KLRNEEKLTDVTLIVEEHRFKA 61
            ||:|.|..:|:|...|....:.....:||.:....|..     .|....:|:......|.|    
Mouse   342 AASPQPVASPSAPGFSRKVSLLQIAENPELQLQPEGFRMPLPAHLDQRAQLSSACSHGEPH---- 402

  Fly    62 HRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKARAMGSIIDYIYTSMLELNYDNIEEILAAA 126
              |.|.|.:::|.......:.::.|.|..|.|                .||.|......|.|..|
Mouse   403 --VQLVAGTNFFHIPLTPASALDVRLDLGNCY----------------EMLTLAKRQGLETLKEA 449

  Fly   127 THVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEEFATTSDFKEMK 191
            .:                |:..:|.|.:....||||.:..:||          |......|:..|
Mouse   450 AY----------------KVLSDNYLQVLRSPDIYGGLSGAER----------ELILQRRFRGHK 488

  Fly   192 VDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQLNESALGDLLRLIKWQHISYKSVDELRNMNCS 256
                |.:::...|.|    |..||.|...::.              .|..::             
Mouse   489 ----RLVVADMCPQD----DSGRLCCYDNVQD--------------AWHPLA------------- 518

  Fly   257 LDKGKQLPLPTSYYNRIKQEHMGHLLNGVVSLKDQSLPQGPTNM-RGMELCLLKIGGFEWNGLTN 320
                 |||                                |..| ||..||              
Mouse   519 -----QLP--------------------------------PEAMSRGCALC-------------- 532

  Fly   321 VIMCFSPKKMNWYELTAIPHIDQCNFGTAVLNNKLFIVGGAYDVFLKEYIHPFG------FCYCP 379
                                         .|.|.||:|.|..:        |.|      |||.|
Mouse   533 -----------------------------TLFNYLFVVSGCQE--------PGGQPSNRVFCYNP 560

  Fly   380 LRNTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSL 444
            |...|..:.|:.|.|....|.|: ..||||:||          ..::.|||||...:.||:.|.|
Mouse   561 LTAIWSEVCPLNQARPHCRLVAL-EGHLYAIGG----------ECLNTVERYDPRLDRWTFAPPL 614

  Fly   445 QEN--RSQHAGVVVGDKLYISGGVHLANILASMWVFDTKTEVW---------QELASMPTPCCDH 498
            ..:  ...|...|..::::::|| .|..:|..   |.|:.:.|         ...|.|       
Mouse   615 PNDTFALAHTATVCANEIFVTGG-SLRYLLLR---FSTQEQRWWAGPTGGSKDRTAEM------- 668

  Fly   499 VLVAVD--------NR-----IYACGG----WHESLT---------EWRVLVEHIY 528
              |||:        ||     :|.|..    |:|..|         :..|:.:|||
Mouse   669 --VAVNGFLYRFDLNRSLGISVYRCSASTRLWYECATYRLPYPDAFQCAVVDDHIY 722

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1812NP_608397.1 BTB 38..142 CDD:279045 18/108 (17%)
PHA03098 46..588 CDD:222983 105/527 (20%)
BACK 151..249 CDD:285009 18/97 (19%)
KELCH repeat 344..390 CDD:276965 14/51 (27%)
KELCH repeat 394..444 CDD:276965 17/49 (35%)
Kelch 406..458 CDD:128874 17/53 (32%)
Kelch_1 448..492 CDD:279660 10/52 (19%)
KELCH repeat 448..492 CDD:276965 10/52 (19%)
Kelch_1 494..539 CDD:279660 14/61 (23%)
KELCH repeat 495..539 CDD:276965 14/60 (23%)
Klhdc7aNP_775603.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 64..99
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..207
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 296..355 6/12 (50%)
Kelch 1 323..370 7/27 (26%)
BACK_like 426..>466 CDD:297737 12/71 (17%)
Kelch 2 488..534 18/160 (11%)
KELCH repeat 527..571 CDD:276965 18/94 (19%)
Kelch 3 537..585 17/56 (30%)
Kelch 538..585 CDD:128874 17/55 (31%)
Kelch_1 574..615 CDD:279660 17/51 (33%)
KELCH repeat 575..615 CDD:276965 17/50 (34%)
Kelch 4 586..628 16/51 (31%)
Kelch 5 631..673 12/54 (22%)
KELCH repeat 663..702 CDD:276965 11/47 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1072
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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