DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1812 and Klhl36

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_666331.1	Gene:	Klhl36 / 234796	MGIID:	2385305	Length:	613	Species:	Mus musculus

Alignment Length:	622	Identity:	177/622 - (28%)
Similarity:	275/622 - (44%)	Gaps:	83/622 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PEEET-LLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINL 92
            |:..| :|:.||:.|......||.|:|||.:..|||.:||..||||.:||. ..|.|:.:.|:.|
Mouse    25 PDHSTAVLQRLNEQRLHGLFCDVVLVVEEQQVPAHRNLLAVCSDYFNSMFT-LGMREAFQKEVEL 88

  Fly    93 YGIKARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGM 157
            .|.....:.:::|::|:|.|||:..||:.||..|..:|:..|:|.|..:|..::..:|.|.:..:
Mouse    89 VGTSYVGLKAVVDFLYSSELELDGSNIDYILETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQEL 153

  Fly   158 ADIYGIMDLSERAYRYMCAHFEEFATTSDF-KEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAI 221
            |.||.:..|......::.:||...:.|.|| :.:.|.:|...|||.......|.||:::...:..
Mouse   154 ASIYSLKRLDAFIDSFVLSHFSTLSFTPDFLQSISVQKLCVYLSSGQVQHKWEYDLLQVALQWLT 218

  Fly   222 EQQLNESALGDLLRLIKW----QHISYKSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLL 282
            :|...|.....:|..|::    :.|..:.|   :...|||       ||:........|...|..
Mouse   219 QQPEREVHTRRVLENIRFPLFPEDILLQRV---KLAMCSL-------LPSEANGEGFVEEAMHYH 273

  Fly   283 NGVVSLKDQSLPQGPTNMRGMELCLLKIGG------FEWNGLTNVIMCF-SPKKMNWYELTAIP- 339
            |.:|:   |.:.|....:...|.|||.:||      .|.:..|    |: ..|...|.:.|::|
Mouse   274 NSLVA---QPVLQTKRTLLRSEECLLFVGGEVSERCLELSDDT----CYLDTKNEQWVKETSLPA 331

  Fly   340 -HIDQCNFGTAVLNNKLFIVGGAYDVFLKEYIHPFG--------FCYCPLRNTWMTIAPIQQDRC 395
             ....|   .|||...:||.||::.       ...|        :.|.|.|..|:.:|.:.|.|.
Mouse   332 RRSHHC---VAVLGGFIFIAGGSFS-------RDNGGNAASNLLYRYDPRRKQWIKVASMNQRRV 386

  Fly   396 RFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKL 460
            .|.|.:: ...|.||||    .||..  .:|:||.|....|.|||:..|......|||.:..|.:
Mouse   387 DFYLASI-EDMLVAVGG----RNENG--ALSSVETYSPKTNSWTYVAGLPRFTYGHAGTIYKDFV 444

  Fly   461 YISG------GVHLANILASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGG---WHES 516
            ||||      |.:..|:|.    :|.:|:||:|...|.|....|.:.::.:.||:.||   ..||
Mouse   445 YISGGHDYQIGPYRKNLLC----YDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDHMES 505

  Fly   517 LTEWRVLVEHIYAYDIETNTWSVETKIPAPKFYTGVTAMGRTIFFVGGL--DSTESIDRASAETM 579
            :..:.||  .:.||..:.|.|:....:......:||......|:.:||.  :|| :..||   ..
Mouse   506 MERFDVL--GVEAYSPQCNQWTRVAPLLQANSESGVAVWQGRIYILGGYSWEST-AFSRA---VQ 564

  Fly   580 AYDLDTKEWWHEKDSWDSPNDV-WESTCVAIYVPNCD 615
            .||.:...|   ....|.||.: ..|.||....|..:
Mouse   565 VYDSEANRW---SRGPDLPNAIAGVSACVCALNPRLE 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	40/103 (39%)
		PHA03098	46..588	CDD:222983	163/574 (28%)
		BACK	151..249	CDD:285009	24/102 (24%)
		KELCH repeat	344..390	CDD:276965	14/53 (26%)
		KELCH repeat	394..444	CDD:276965	18/49 (37%)
		Kelch	406..458	CDD:128874	19/51 (37%)
		Kelch_1	448..492	CDD:279660	16/49 (33%)
		KELCH repeat	448..492	CDD:276965	16/49 (33%)
		Kelch_1	494..539	CDD:279660	13/47 (28%)
		KELCH repeat	495..539	CDD:276965	13/46 (28%)
Klhl36	NP_666331.1	BTB	35..138	CDD:279045	40/103 (39%)
		PHA03098	58..583	CDD:222983	161/572 (28%)
		BACK	147..247	CDD:197943	23/99 (23%)
		Kelch 1	294..343		16/55 (29%)
		Kelch	<315..343	CDD:128874	8/30 (27%)
		Kelch_1	332..382	CDD:279660	14/59 (24%)
		KELCH repeat	333..381	CDD:276965	14/57 (25%)
		Kelch 2	344..395		14/58 (24%)
		Kelch_1	384..429	CDD:279660	18/51 (35%)
		KELCH repeat	385..429	CDD:276965	18/50 (36%)
		Kelch 3	396..442		19/51 (37%)
		KELCH repeat	432..479	CDD:276965	17/50 (34%)
		Kelch	444..491	CDD:128874	15/50 (30%)
		Kelch 4	444..491		15/50 (30%)
		KELCH repeat	481..531	CDD:276965	13/51 (25%)
		Kelch_1	484..530	CDD:279660	13/47 (28%)
		Kelch 5	492..544		14/53 (26%)
		KELCH repeat	534..580	CDD:276965	13/52 (25%)
		Kelch 6	545..593		16/54 (30%)
		Kelch	545..591	CDD:128874	15/52 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45416
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45632
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030