DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and Klhl26

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_848886.1	Gene:	Klhl26 / 234378	MGIID:	2443079	Length:	606	Species:	Mus musculus

Alignment Length:	634	Identity:	171/634 - (26%)
Similarity:	278/634 - (43%)	Gaps:	77/634 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TSAAAKIPVNPVSPEEET---------------LLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVV 65
            :|.:::.|..|.|..:..               ||:||..||.:.:|.||.|.|....|.||:||
Mouse     7 SSGSSQSPERPSSLADRNGALKCTFSAAGHSTGLLQGLAALRAQGQLLDVVLTVNSEAFHAHKVV 71

  Fly    66 LAASSDYFCAMFADCAMIESRKDEINLYGIKARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQ 130
            |||.||||.|||.. .|.|:.:..|.|.|:.||.:..|||:.|::.:.|:.|.::::|.||..:|
Mouse    72 LAACSDYFRAMFTG-GMREANQAVIQLQGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQ 135

  Fly   131 VREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEEFATTSDFKEMKVDQL 195
            :..|::.|..||.|.:.:|.||.|..||..:.:..|.|....:...||.:.|...||..:.:::|
Mouse   136 MLPVVELCEDFLKAAMSVETCLHIGQMATTFSLTSLRESVDAFTFRHFLQIAAEEDFLRLPLERL 200

  Fly   196 RFILSSNYPIDVAEQDLVRLVCSFAIEQQLNESALGDLLRLIKWQHISY------KSVDELRNMN 254
            .|.|.||.....||.||.|....:........:....:||     |:.:      :.||.::.::
Mouse   201 VFFLQSNRLQSCAEIDLFRAAVRWLQHDPARRARASLVLR-----HVRFPLMQPAELVDSVQTLD 260

  Fly   255 CSLDKG--KQLPLPTSYYNRIKQEHMGHLLNGVVSLKDQSLPQGPTNMRGMELCLLKIGGFEWNG 317
            ..||..  :|..|....|:             |:..:...:....|.:|.....|:..||..:..
Mouse   261 VMLDDALCRQYLLEAFSYH-------------VLPCRQHDMQSPRTAVRSDVASLVAFGGTPYTD 312

  Fly   318 -----LTNVIMCFSPKKMNWYELTAIPHIDQCNFGTAVLNNKLFIVGGAYDVFLKEYIHPFG--- 374
                 .:.|.....|...::.|||.: .:...:.|.|||:|.:::.||      :...|..|
Mouse   313 SDRAVSSKVFQLPEPGARHFRELTEM-ELGCSHAGVAVLDNFVYVAGG------QHLQHRSGEGA 370

  Fly   375 ----FCYCPLRNTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAK 435
                :.|.|.||.|:.:..:::.|.:|.|.|:|.. |||.||      ......:::||||...:
Mouse   371 VDACYRYDPQRNRWLRLRALRESRVQFQLTALGGL-LYATGG------RNRAGSLASVERYCPRR 428

  Fly   436 NVWTYMPSLQENRSQHAGVVVGDKLYISGGVHL-ANILASMWVFDTKTEVWQELASMPTPCCDHV 499
            :.|.:...|:.....|||.....:||||||..: |....::..:|...:.|:..|.|..|...|.
Mouse   429 DSWDFACPLKRRTWGHAGAAAAGRLYISGGYGVSAEDKKALQCYDPAADRWEPRAPMREPRVLHA 493

  Fly   500 LVAVDNRIYACGGWHESLTE-WRVLVEHIYAYDIETNTWSVETKIPAPKFYTGVTAMGRTIFFVG 563
            ::....||||.||..:.:.. :.||....|..|  .:.|:..|.:.|.:...|...:.|.|:.||
Mouse   494 MLGAAGRIYALGGRMDHVDRCFDVLAVEYYVPD--ADQWTSVTPMRAGQSEAGCCLLERKIYIVG 556

  Fly   564 GLDSTESIDRASAETMAYDLDTKEWWHEKDSWDSPNDVWESTCVAIYVP 612
            |.:  ..::..:.....|:.:|.||  |:| ...|.......|.|:.:|
Mouse   557 GYN--WRLNNVTGIVQVYNTETDEW--ERD-LHFPESFAGIACAAVLLP 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	42/103 (41%)
		PHA03098	46..588	CDD:222983	153/563 (27%)
		BACK	151..249	CDD:285009	26/103 (25%)
		KELCH repeat	344..390	CDD:276965	14/52 (27%)
		KELCH repeat	394..444	CDD:276965	15/49 (31%)
		Kelch	406..458	CDD:128874	14/51 (27%)
		Kelch_1	448..492	CDD:279660	13/44 (30%)
		KELCH repeat	448..492	CDD:276965	13/44 (30%)
		Kelch_1	494..539	CDD:279660	13/45 (29%)
		KELCH repeat	495..539	CDD:276965	12/44 (27%)
Klhl26	NP_848886.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		3/12 (25%)
		BTB_POZ_KLHL26	36..156	CDD:349564	49/120 (41%)
		PHA03098	56..588	CDD:222983	156/571 (27%)
		BACK	151..247	CDD:391941	26/100 (26%)
		Kelch 1	301..352		12/51 (24%)
		KELCH repeat	343..390	CDD:276965	14/52 (27%)
		Kelch 2	353..404		13/56 (23%)
		KELCH repeat	394..438	CDD:276965	15/50 (30%)
		Kelch 3	406..451		14/50 (28%)
		KELCH repeat	441..487	CDD:276965	14/45 (31%)
		Kelch 4	452..499		13/46 (28%)
		KELCH repeat	489..536	CDD:276965	13/48 (27%)
		Kelch 5	501..550		13/50 (26%)
		KELCH repeat	541..597	CDD:276965	14/60 (23%)
		Kelch 6	552..599		13/51 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45416
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_112332
Panther	1	1.100	-	-	O	PTHR45632
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.930