Protein Alignment CG1812 and Klhl14

DIOPT Version :10

• Sequence 1: NP_608397.1
• Gene: CG1812 / 33049
• FlyBaseID: FBgn0031119
• Length: 616
• Species: Drosophila melanogaster
• Sequence 2: NP_001074872.1
• Gene: Klhl14 / 225266
• MGIID: 1921249
• Length: 630
• Species: Mus musculus
• Alignment Length: 668
• Identity: 158/668 - (23%)
• Similarity: 279/668 - (41%)
• Gaps: 144/668 - (21%)

  Fly    32 ETLLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFA------------------ 78
            :.||.|||.|..::...||||..:..:|..|:.|||:.|.||.::|:
Mouse    17 DNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAP 81

  Fly    79 --------------------------------DCAMIESRK--DEINLYGIKARAMGSIIDYIYT 109
                                            |..::.|.:  :.:.|.|..:..:..:::|:||
Mouse    82 KDQQQQQQPQQQPPQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIGLRLVLEYLYT 146

  Fly   110 SMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLSERAYRYM 174
            :.:.|:.|.:||:|:.:..:.:.:|...|..||..:|.::|...:..:|.::|:.:..:.|.:|:
Mouse   147 ANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANKYL 211

  Fly   175 CAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRL-VCSFAIEQQLNESALGDLLRLIK 238
                     ..|...:..:::|.:|.|..|...:|..|.:: |.....:::.......||::.::
Mouse   212 ---------VEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLR 267

  Fly   239 WQHI-------SYKSVDELRN-----------MNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGV 285
            :..|       ..:|||.:|.           ||..|...:| ....|..:||:......||.|
Mouse   268 FALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPFRQ-HCRQSLASRIRSNKKMLLLVG- 330

  Fly   286 VSLKDQSLPQGPTNMRGMELCLLKIGGFEWNGLTNVIMCFSPKKMNWYELTAIPHIDQCNFGTAV 350
                  .||.||..:.                 :|::..:..:|..|..||.:|: :..:.....
Mouse   331 ------GLPPGPDRLP-----------------SNLVQYYDDEKKTWKILTIMPY-NSAHHCVVE 371

  Fly   351 LNNKLFIVGGAYDVFLKEYIHPFGFC--YCPLRNTWMTIAPIQQDR-----CRFSLNAVGTQHLY 408
            :.|.||::||. |.:.....|...|.  |.|..|:|:.:.|:|:.|     ||..      :|||
Mouse   372 VENFLFVLGGE-DQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLD------KHLY 429

  Fly   409 AVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHLANILA 473
            .:||    .||..  .:|:||.|::..|.|.|:.||.:..:.|||.|...|:|||||||....:.
Mouse   430 VIGG----RNETG--YLSSVECYNLDTNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVP 488

  Fly   474 SMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWH-ESLTEWRVLVEHIYAYDIETNTW 537
            .::.:|...:||.....|.|....|.|..:::|:||.||.| :..:...|::  :..||.:.:.|
Mouse   489 WLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVML--VECYDPKGDQW 551

  Fly   538 SV-ETKIPAPKFYTGVTAMGRTIFFVGGLDSTESIDRASAETMAYDLDTKEWWHEKDSW-DSPND 600
            :: :|.|...:...|...:..:|:.|||.         |....||...|..:..||.:| :...|
Mouse   552 NILQTPILEGRSGPGCAVLDDSIYLVGGY---------SWSMGAYKSSTICYCPEKGTWTELEGD 607

  Fly   601 VWE----STCVAIYVPNC 614
            |.|    ..|..:.:|.|
Mouse   608 VAEPLAGPACATVILPAC 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB_POZ	33..151	CDD:453885	36/169 (21%)
		PHA03098	46..588	CDD:222983	143/621 (23%)
		KELCH repeat	344..390	CDD:276965	12/47 (26%)
		KELCH repeat	394..444	CDD:276965	17/54 (31%)
		KELCH repeat	448..492	CDD:276965	15/43 (35%)
		KELCH repeat	495..539	CDD:276965	12/44 (27%)
Klhl14	NP_001074872.1	BTB_POZ_KLHL14_printor	1..190	CDD:349552	37/172 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	69..117		1/47 (2%)
		BACK_KLHL14	183..284	CDD:350528	18/109 (17%)
		Kelch 1	325..374		13/73 (18%)
		NanM	326..579	CDD:442289	80/292 (27%)
		KELCH repeat	365..412	CDD:276965	12/47 (26%)
		Kelch 2	375..426		16/57 (28%)
		KELCH repeat	416..460	CDD:276965	18/55 (33%)
		Kelch 3	427..473		20/51 (39%)
		KELCH repeat	463..508	CDD:276965	16/44 (36%)
		Kelch 4	475..520		14/44 (32%)
		Kelch 5	522..572		12/51 (24%)
		Kelch_1	562..604	CDD:396078	12/50 (24%)
		KELCH repeat	562..604	CDD:276965	12/50 (24%)
		Kelch 6	574..622		15/56 (27%)