Protein Alignment CG1812 and Klhl11

DIOPT Version :10

• Sequence 1: NP_608397.1
• Gene: CG1812 / 33049
• FlyBaseID: FBgn0031119
• Length: 616
• Species: Drosophila melanogaster
• Sequence 2: NP_766153.1
• Gene: Klhl11 / 217194
• MGIID: 2388648
• Length: 709
• Species: Mus musculus
• Alignment Length: 694
• Identity: 135/694 - (19%)
• Similarity: 247/694 - (35%)
• Gaps: 195/694 - (28%)

  Fly     6 APAVTPAATATSAAAKIPV------------------------------------------NPVS 28
            |.||..||.|.:|||...|                                          :...
Mouse     2 AAAVAAAAAAAAAAASFQVLEMESMETAVAGSASLAAEVRGSGTVDFVTGAGISTLVDTGGSDPG 66

  Fly    29 PEEE-----TLLRGLNKLRNEEK----LTDVTLI---VEEHRFKAHRVVLAASSDYFCAMFADCA 81
            ||.|     |....|:..:||::    ..|:||.   .....|:|||.||||:::||..:.:. .
Mouse    67 PEAEDFECSTHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSG-Q 130

  Fly    82 MIESRKDEINLY------GIKARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTI 140
            ..|||...:.:.      |.:...:.::|:|:||..:.::..::.|:|..|....:..:.:.|..
Mouse   131 FSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGE 195

  Fly   141 FLGAKIEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSS-NYP 204
            ||..|:.:.||:||..:|.:|.:..|:.:|...:..:|.:.....:|..:....:|..||. ...
Mouse   196 FLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFYKVIQDEEFYTLPFHLIRDWLSDLEIT 260

  Fly   205 IDVAE---QDLVRLVCSFAIEQQLNESALGDLLRLIKWQHISYKSVDELRNMNCSLDKGKQLPLP 266
            :|..|   :.:::.|...|.|::.....|..||||.:.:                         |
Mouse   261 VDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMK-------------------------P 300

  Fly   267 TSYYNRIKQEHMGHLLNGVV------------SLKDQSLPQG----PTNM--------RGMELCL 307
            |.....:|.|.:  :.|..|            :|:.:::..|    ||:.        :.|:: :
Mouse   301 TYLTRHVKPERL--VANNEVCVKLVAEAVERHALRAENIQSGTLQQPTSQVSLLPRYGQNMDV-I 362

  Fly   308 LKIGGFEWNG--LTNVIMCFSPKKMNWYELTAI-PHIDQCNFGTAVLNNKLFIVGGAYDVFLKEY 369
            :.|||....|  |:..:..|..:. .|..|..| .|:|  ....|:..:.:::.|.....|.|..
Mouse   363 MVIGGVSEGGDYLSECVGYFVDED-RWVNLPHIHNHLD--GHAVAITESYVYVAGSMEPGFAKTV 424

  Fly   370 IHPFGFCYCPLRNTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIA 434
            ..     |.|..|||..:..:...:..|.|..|..: ||::||     :........:|..|:..
Mouse   425 ER-----YNPNLNTWEHVCSLMTRKHSFGLTEVKGK-LYSIGG-----HGNFSPGFKDVTVYNPE 478

  Fly   435 KNVWTYMPSLQENRSQHAGVVVGDK-LYISGGVHL-----ANILASMWVFDTKTEVWQELASMP- 492
            .:.|..:.|..:.......:.:.|: :||:....:     ..:.|.:..:||:|..||::.|:|
Mouse   479 LDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPL 543

  Fly   493 -------------------TPCC--------------------DHVLVAVD-------------- 504
                               ..||                    |.:|.::.
Mouse   544 IDNYCFFQMSVVNSNFYQTASCCPKSYSLENEEAVRKIAGQVSDEILESLPPEVLSIEGAAICYY 608

  Fly   505 -NRIYACGGWHESLTEWRVLVEHIYAYDIETNTWSVETKIPAPK 547
             :.::..|||..|....:...:..|.|..|...|.:...:|.|:
Mouse   609 RDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPMPQPR 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB_POZ	33..151	CDD:453885	32/130 (25%)
		PHA03098	46..588	CDD:222983	118/607 (19%)
		KELCH repeat	344..390	CDD:276965	9/45 (20%)
		KELCH repeat	394..444	CDD:276965	10/49 (20%)
		KELCH repeat	448..492	CDD:276965	10/49 (20%)
		KELCH repeat	495..539	CDD:276965	12/78 (15%)
Klhl11	NP_766153.1	BTB_POZ_KLHL11	72..206	CDD:349550	32/134 (24%)
		PHA03098	91..554	CDD:222983	104/505 (21%)
		BACK_KLHL11	201..288	CDD:350526	18/86 (21%)
		Kelch 1	361..408		12/50 (24%)
		KELCH repeat	400..440	CDD:276965	9/44 (20%)
		Kelch 2	409..454		11/49 (22%)
		KELCH repeat	444..489	CDD:276965	11/50 (22%)
		Kelch 3	456..502		8/50 (16%)
		KELCH repeat	492..542	CDD:276965	10/49 (20%)
		Kelch 4	504..557		10/52 (19%)
		KELCH repeat	568..650	CDD:276965	10/81 (12%)
		Kelch 5	611..662		10/42 (24%)
		Kelch	612..658	CDD:128874	10/41 (24%)