DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1812 and Klhdc8a

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	NP_659059.1	Gene:	Klhdc8a / 213417	MGIID:	2442630	Length:	350	Species:	Mus musculus

Alignment Length:	329	Identity:	77/329 - (23%)
Similarity:	134/329 - (40%)	Gaps:	61/329 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 IGGFEWNGLTNVIMCF---SPKKMNWYELTAIPHIDQCNFGTAV--LNNKLFIVGGAYDVFLKEY 369
            |||.:.||:.  :.||   ||:...|   |::|.:.....|.|:  |..::.::||.
Mouse    36 IGGCDDNGVP--MDCFEVYSPEADQW---TSLPSLPTARAGVAITALGKRIMVIGGV-------- 87

  Fly   370 IHPFGFCYCPLR---------NTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGI-LDDDNEEALRM 424
                |....|::         ..|...:.:::.....|:.| ....:||.||: ||      ||.
Mouse    88 ----GTNQLPVKVVEMYNIDEGKWKKRSVLREAAMGISVTA-KDYRVYAAGGMGLD------LRP 141

  Fly   425 ISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHLANILASMWVFDTKTEVWQELA 489
            .:.::.||:.|::|..:..:...|......:.|.|:|:.||......:.:..|||.::..|.:..
Mouse   142 HNYLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIESRSWTKFP 206

  Fly   490 SMPTPCCDHVLVAVDNRIYACGGWHES-LTEWRVLVEHIYAYDIETNTW-----SVETKIPAPKF 548
            ::|........|.:||.:|:.||..:. |......:..:..:|:|...|     |...|.....|
Mouse   207 NIPCKRAFSSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKKRRADF 271

  Fly   549 YTGVTAMGRTIFFVGGLDSTESIDRASAETMAYDLDTKEWWH-EKDSWDS--PNDVWESTCVAIY 610
            ..|..: ||.| ..|||.:..::           |:|.|.:| ||:.|::  |.......|.:|.
Mouse   272 VAGGLS-GRVI-VAGGLGNQPTV-----------LETAEAFHPEKNKWEALPPMPTPRCACSSIV 323

  Fly   611 VPNC 614
            ..||
Mouse   324 FKNC 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045
		PHA03098	46..588	CDD:222983	67/298 (22%)
		BACK	151..249	CDD:285009
		KELCH repeat	344..390	CDD:276965	8/56 (14%)
		KELCH repeat	394..444	CDD:276965	14/50 (28%)
		Kelch	406..458	CDD:128874	13/52 (25%)
		Kelch_1	448..492	CDD:279660	10/43 (23%)
		KELCH repeat	448..492	CDD:276965	10/43 (23%)
		Kelch_1	494..539	CDD:279660	10/50 (20%)
		KELCH repeat	495..539	CDD:276965	10/49 (20%)
Klhdc8a	NP_659059.1	Kelch 1	1..31
		PHA03098	<5..209	CDD:222983	44/196 (22%)
		KELCH repeat	21..65	CDD:276965	12/33 (36%)
		Kelch 2	32..79		15/47 (32%)
		KELCH repeat	69..162	CDD:276965	22/111 (20%)
		Kelch 3	81..127		7/58 (12%)
		Kelch 4	128..175		13/52 (25%)
		PHA03098	<129..333	CDD:222983	55/218 (25%)
		KELCH repeat	165..209	CDD:276965	10/43 (23%)
		Kelch 5	176..222		10/45 (22%)
		KELCH repeat	212..265	CDD:276965	11/52 (21%)
		Kelch 6	224..278		11/54 (20%)
		KELCH repeat	268..314	CDD:276965	16/58 (28%)
		Kelch 7	279..326		15/58 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900