Protein Alignment CG1812 and Klhl32

DIOPT Version :10

• Sequence 1: NP_608397.1
• Gene: CG1812 / 33049
• FlyBaseID: FBgn0031119
• Length: 616
• Species: Drosophila melanogaster
• Sequence 2: NP_001156492.1
• Gene: Klhl32 / 212390
• MGIID: 3612790
• Length: 620
• Species: Mus musculus
• Alignment Length: 567
• Identity: 163/567 - (28%)
• Similarity: 264/567 - (46%)
• Gaps: 72/567 - (12%)

  Fly    32 ETLLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIK 96
            :|:|..||:.|::..|.|||||.||.:|.||:.||||.||||.|||:.| |:||..||:||.|:.
Mouse    26 DTVLAALNQQRSDGILCDVTLIAEEQKFHAHKAVLAACSDYFRAMFSLC-MVESGADEVNLRGVT 89

  Fly    97 ARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIY 161
            :..:...:::.||..:.|....|:::|||.:|:|:.|:::.|:.:|..::...|.|.:..:||::
Mouse    90 SLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLF 154

  Fly   162 GIMDLSERAYRYMCAHFEEF--ATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQ 224
            .:..|.:....::..|..|.  :...|...:....|:.:|.|:....::|:.:.:|...: :|..
Mouse   155 HLTLLEKAVIDFLVKHLSELLKSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRW-LEHN 218

  Fly   225 LNESALGDLLRLIKWQHISYKSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVVSLK 289
            .:...|.:||:.|::   ....||.|..:..|....:.....|:..|...:.|
Mouse   219 CHYQHLDELLQYIRF---GLMDVDTLHTVALSHPLVQASETATALVNEALEYH------------ 268

  Fly   290 DQSLPQGP------TNMRGMELCLLKIGGFEWNGLTNVIMC-------FSPKKM---------NW 332
             ||:...|      |..|.....|..|||.:..      :|       |:|...         ||
Mouse   269 -QSIYAQPVWQTRRTKPRFQSDTLYIIGGKKRE------VCKVKELRYFNPVDQENALIAAIANW 326

  Fly   333 YELTAIPHIDQCNFGTAVLNNKLFIVGGAYDVFLKEYIHPFG-------FC-YCPLRNTWMTIAP 389
            .||..:| :.:.:...||:.:.||:.||       |..|..|       .| |.|..|:|..|||
Mouse   327 SELAPMP-VGRSHHCVAVMGDFLFVAGG-------EVEHASGRTCAVRTACRYDPRSNSWAEIAP 383

  Fly   390 IQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGV 454
            ::..|..|.|.|: .::||||||     ..|..:::..||||...||.||::.|...:.|.|||.
Mouse   384 MKNCREHFVLGAM-DEYLYAVGG-----RNELCQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGY 442

  Fly   455 VVGDKLYISGGV-HLANILASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWHESLT 518
            |....|:||||| :.|.....:.|::.....|...:.|......|.:.||..::|..||......
Mouse   443 VADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYN 507

  Fly   519 EWRVLVEHIYAYDIETNTWS-VETKIPAPKFYTGVTAMGRTIFFVGG 564
            ..|:||.||.:|:|:|:.|: ....:...:..:||......|:.|||
Mouse   508 NDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGG 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB_POZ	33..151	CDD:453885	48/117 (41%)
		PHA03098	46..588	CDD:222983	158/553 (29%)
		KELCH repeat	344..390	CDD:276965	16/53 (30%)
		KELCH repeat	394..444	CDD:276965	19/49 (39%)
		KELCH repeat	448..492	CDD:276965	14/44 (32%)
		KELCH repeat	495..539	CDD:276965	15/44 (34%)
Klhl32	NP_001156492.1	BTB_POZ_KLHL32	14..146	CDD:349570	49/120 (41%)
		BACK_KLHL32_BKLHD5	139..236	CDD:350546	18/100 (18%)
		Kelch	291..346	CDD:128874	14/61 (23%)
		NanM	324..595	CDD:442289	78/245 (32%)
		KELCH repeat	336..384	CDD:276965	16/54 (30%)
		KELCH repeat	388..433	CDD:276965	20/50 (40%)
		KELCH repeat	436..482	CDD:276965	15/45 (33%)
		KELCH repeat	484..534	CDD:276965	15/49 (31%)