DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and klhl26

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	XP_031762238.1	Gene:	klhl26 / 100494192	XenbaseID:	XB-GENE-6036105	Length:	630	Species:	Xenopus tropicalis

Alignment Length:	627	Identity:	179/627 - (28%)
Similarity:	279/627 - (44%)	Gaps:	112/627 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TLLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKA 97
            |||:||..||.:.:|.||.|.:....|:.|:|||||.||||.|||.. .|.|:.:|.|.|.|:.:
Frog    63 TLLQGLTTLRAQGQLLDVILTINNEVFQVHKVVLAACSDYFRAMFTG-GMREANQDVIELKGVSS 126

  Fly    98 RAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYG 162
            |.:..|||:.|::.:.|:.|.|.::|.||..:|:..|::.|..||.:.:.:|.||.|..||..:.
Frog   127 RGLRHIIDFAYSAEVTLDLDCIHDVLGAAVFLQMVPVVELCEEFLKSAMSVETCLNIGQMATTFS 191

  Fly   163 IMDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQLNE 227
            :..|.|....:...||.:.|...||..:.:::|.|.|.||...:.:|.||....
Frog   192 LASLKESVDSFTFKHFLKIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFHAA----------- 245

  Fly   228 SALGDLLRLIKWQHISYKSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGV----VSL 288
                     |:|....|........:.|.:    :.||..|          ..|::.|    :.:
Frog   246 ---------IRWLQFDYSRRANASRVLCHI----RFPLMKS----------SELVDSVQTVDIMV 287

  Fly   289 KD-------------QSLP------QGP-TNMRGMELCLLKIGGFEWNGLTNVI---MCFSP--- 327
            :|             |.||      |.| |.:|.....|:..||..:......:   :.:.|
Frog   288 EDALCRHYLLEAFNYQILPFRQHEMQSPRTVIRSDVFSLVTFGGTPYTDNDRTVSNKVYYLPDIC 352

  Fly   328 ----KKMNWYELTAIPHIDQCNFG-TAVLNNKLFIVGGAYDVFLKEYIHPFG-----FCYCPLRN 382
                |.:|..|:       .|:.. .|||:|.:::|||.    |.:|....|     |.|.|..|
Frog   353 ARQFKDLNEMEI-------GCSHACVAVLDNFVYVVGGQ----LLQYRSGEGAVDVCFRYDPHLN 406

  Fly   383 TWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQEN 447
            .|:.|..:|:.|.:|.|:.:... |||.||      ......:::||||....|.|||:.||:..
Frog   407 QWLRILAMQESRIQFQLHVLNGM-LYATGG------RNRSGSLASVERYCPKNNEWTYVCSLKRR 464

  Fly   448 RSQHAGVVVGDKLYISGGVHLA-NILASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACG 511
            ...|||..:|.:||||||..:: :...|:..:|...:.|:..:.|..|...|.:|...|||||.|
Frog   465 TWGHAGATLGGRLYISGGYGVSVDDKKSLHCYDPSVDQWEFKSPMNEPRVLHAMVGTKNRIYALG 529

  Fly   512 GWHESLTE-WRVL-VEHIYAYDIETNTWSVETKIPAPKFYTGVTAMGRTIFFVGG----LDSTES 570
            |..:.:.. :.|| ||:   |..||:||:....:.|.:...|...:.:.|:.|||    |::..|
Frog   530 GRMDHVDRCFDVLAVEY---YVPETDTWTTVIPMKAGQSEAGCCLLDKKIYIVGGYNWHLNNVTS 591

  Fly   571 IDRASAETMAYDLDTKEWWHEKDSWDSPNDVWESTCVAIYVP 612
            |      ...|:.:|.||  |:| ...|.......|:::.:|
Frog   592 I------VQVYNTETDEW--ERD-LHFPESFAGIACISVILP 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	41/103 (40%)
		PHA03098	46..588	CDD:222983	165/588 (28%)
		BACK	151..249	CDD:285009	23/97 (24%)
		KELCH repeat	344..390	CDD:276965	17/51 (33%)
		KELCH repeat	394..444	CDD:276965	16/49 (33%)
		Kelch	406..458	CDD:128874	18/51 (35%)
		Kelch_1	448..492	CDD:279660	13/44 (30%)
		KELCH repeat	448..492	CDD:276965	13/44 (30%)
		Kelch_1	494..539	CDD:279660	19/46 (41%)
		KELCH repeat	495..539	CDD:276965	18/45 (40%)
klhl26	XP_031762238.1	BTB_POZ_KLHL26	72..180	CDD:349564	42/108 (39%)
		PHA03098	80..621	CDD:222983	169/605 (28%)
		BACK_KLHL26	175..271	CDD:350540	26/119 (22%)
		KELCH repeat	367..414	CDD:276965	16/50 (32%)
		KELCH repeat	418..462	CDD:276965	17/50 (34%)
		KELCH repeat	465..511	CDD:276965	14/45 (31%)
		KELCH repeat	513..561	CDD:276965	18/50 (36%)
		KELCH repeat	564..605	CDD:276965	12/48 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45416
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45632
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030