DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and klhl14

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	XP_002934163.1	Gene:	klhl14 / 100493162	XenbaseID:	XB-GENE-951654	Length:	610	Species:	Xenopus tropicalis

Alignment Length:	648	Identity:	155/648 - (23%)
Similarity:	277/648 - (42%)	Gaps:	124/648 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ETLLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFA------------------ 78
            :.||.|||.|..::...||||..:..:|..|:.|||:.|.||.::|:
Frog    17 DNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPGQDVLPNVPKDQQQQ 81

  Fly    79 -------------DCAMIESRK-DEINLYGIKARAMGSIIDYIYTSMLELNYDNIEEILAAATHV 129
                         |..::..|. :.:.|.|..:..:..:::|:||:.:.|:.|.:||:|:.:..:
Frog    82 QSEEPGTPSSSPDDKLLVSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKIL 146

  Fly   130 QVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEEFATTSDFKEMKVDQ 194
            .:.:|......||..:|.::|...:..:|.::.:.:..:.|.:|:         ..|...:..::
Frog   147 HIPQVTKLSVQFLNDQISVQNYKQVCKIAALHSLEETKKLANKYL---------VEDVLLLNFEE 202

  Fly   195 LRFILSSNYPIDVAEQDLVRL-VCSFAIEQQLNESALGDLLRLIKWQHI-------SYKSVDELR 251
            :|.:|.|..|...:|..|.:: |.....:::.......||::.:::..|       ..:|||.:|
Frog   203 MRAMLDSLPPPVESELALFQMTVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMR 267

  Fly   252 N-----------MNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVVSLKDQSLPQGPTNMRGMEL 305
            :           ||..|...:| ....|..:||:......||.|       .||.||..:.
Frog   268 SDPVCQKLLLDAMNYHLMPFRQ-HCRQSVASRIRSNKKMLLLVG-------GLPPGPDRLP---- 320

  Fly   306 CLLKIGGFEWNGLTNVIMCFSPKKMNWYELTAIPHIDQCNFGTAVLNNKLFIVGGAYDVFLKEYI 370
                         :|::..:..:|..|..||.:|: :..:.....:.|.||::||. |.:.....
Frog   321 -------------SNLVQYYDDEKKTWKILTIMPY-NSAHHCVVEVENFLFVLGGE-DQWNPNGK 370

  Fly   371 HPFGFC--YCPLRNTWMTIAPIQQDR-----CRFSLNAVGTQHLYAVGGILDDDNEEALRMISNV 428
            |...|.  |.|..|:|:.:.|:|:.|     ||..      :|||.:||    .||..  .:|:|
Frog   371 HSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLE------KHLYVIGG----RNETG--YLSSV 423

  Fly   429 ERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHLANILASMWVFDTKTEVWQELASMPT 493
            |.|::..|.|.|:.||.:..:.|||.|...|:|||||||....:..::.:|...:||.....|.|
Frog   424 ECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVQWLYCYDPVMDVWARKQDMNT 488

  Fly   494 PCCDHVLVAVDNRIYACGGWH-ESLTEWRVLVEHIYAYDIETNTWSV-ETKIPAPKFYTGVTAMG 556
            ....|.|..:::|:||.||.| :..:...|::  :..||.:.:.|:: :|.|...:...|...:.
Frog   489 KRAIHALAVMNDRLYAIGGNHLKGFSHLDVML--VECYDPKGDQWNILQTPILEGRSGPGCAVLD 551

  Fly   557 RTIFFVGGLDSTESIDRASAETMAYDLDTKEWWHEKDSW-DSPNDVWE----STCVAIYVPNC 614
            ...:.|||.  :.|:....:.|:.|.       .||.|| :...||.|    ..|..:.:|.|
Frog   552 DRCYLVGGY--SWSMGAYKSSTICYS-------PEKASWTELEGDVAEPLAGPACATVILPAC 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	29/135 (21%)
		PHA03098	46..588	CDD:222983	139/601 (23%)
		BACK	151..249	CDD:285009	16/105 (15%)
		KELCH repeat	344..390	CDD:276965	12/47 (26%)
		KELCH repeat	394..444	CDD:276965	17/54 (31%)
		Kelch	406..458	CDD:128874	20/51 (39%)
		Kelch_1	448..492	CDD:279660	15/43 (35%)
		KELCH repeat	448..492	CDD:276965	15/43 (35%)
		Kelch_1	494..539	CDD:279660	12/45 (27%)
		KELCH repeat	495..539	CDD:276965	12/44 (27%)
klhl14	XP_002934163.1	BTB_POZ_KLHL14_printor	1..170	CDD:349552	36/152 (24%)
		PHA03098	30..582	CDD:222983	142/610 (23%)
		BACK_KLHL14	163..264	CDD:350528	17/109 (16%)
		KELCH repeat	345..392	CDD:276965	12/47 (26%)
		KELCH repeat	396..440	CDD:276965	18/55 (33%)
		KELCH repeat	443..488	CDD:276965	16/44 (36%)
		KELCH repeat	542..584	CDD:276965	11/50 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45416
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45632
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030