DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1812 and klhl15

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	XP_002935246.1	Gene:	klhl15 / 100492783	XenbaseID:	XB-GENE-1002764	Length:	604	Species:	Xenopus tropicalis

Alignment Length:	633	Identity:	156/633 - (24%)
Similarity:	274/633 - (43%)	Gaps:	145/633 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SPEEETLLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMF-ADCAMIESRKDEIN 91
            |..:.::..|...|..|..|.||||::|:|:|:||:.:||..||||..|| ||  |.|..:|:|.
Frog    11 SLHDTSVSAGFRALYEEGLLVDVTLVIEDHQFQAHKALLATQSDYFRIMFTAD--MRERDQDKIY 73

  Fly    92 LYGIKARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAG 156
            |.|:.|.....::.::|...::|:...:.|||.||.:||:.||:..|..||.|||.::||..|..
Frog    74 LKGLTATGFSHVLQFMYYGNIDLSMATVHEILQAAMYVQLTEVVKFCCSFLMAKICLDNCAEIMR 138

  Fly   157 MADIYG--IMDLSERAYRYMCAHFEEFATTSDF-KEMKVDQLRFILS----SNYP-IDVAEQDLV 213
            :.|.:.  :..:.|:...::..:|....:..|| ..:..::|:..|.    |.:| |::.|
Frog   139 LLDDFSVDVEGVREKLDLFLLENFVPLMSRPDFLSYLSFEKLKSYLDNDRLSRFPEIELYE---- 199

  Fly   214 RLVCSFAIEQQLNESALGDLLRLIKWQHISYKSVDELRNMN-CSLDKGKQLPLPTSYYNRIK--- 274
                  |::..|.....       :|:|..    ..::|:. |       |..|.:.|.::|
Frog   200 ------AVQAWLRHDRR-------RWRHTD----TIIQNIRFC-------LMTPANVYEKVKTSE 240

  Fly   275 --------QEHMGHLLNGVVSLKDQSLPQGPTN-----------MRGMELCLLKIGGFEWNGLTN 320
                    :..:...||...::.:|.|.:..:|           .|||      ||....|  :.
Frog   241 FYRYSRQLRHEVEQALNYFHNVSEQPLMEMKSNHIRSAKPQTAVFRGM------IGHSMVN--SK 297

  Fly   321 VIMCFSPKKMNWYELTA--IPHIDQCNFGTAVLNNKLFIVGGAYDVFLKEYIHPFG--------F 375
            :::...|:.  |:||..  :|....|   .|::||.:|::||       |.:.|.|        |
Frog   298 ILLLHKPRV--WWELEGPLVPLRPDC---LAIVNNFVFLLGG-------EELGPDGEFHASSKVF 350

  Fly   376 CYCPLRNTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTY 440
            .|.|.:|:|:.:|.:...|..|::..:| :::|||.|...|:.      ..:.|||||.:|.|.:
Frog   351 RYDPRQNSWLRMADMSVPRSEFAVGVIG-RYIYAVAGRTRDET------FYSTERYDIIENKWEF 408

  Fly   441 MPSLQENRSQHAGVVVGDKLYISGGVHLANILASMWVFDTK---------------TEVWQELAS 490
            :.....|:..|.|.|:.:||:|:||:..::....:.|||..               |..|:....
Frog   409 VDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKVGTVEQRTRRTQVLTNCWENKCK 473

  Fly   491 MPTPCCDHVLVAVDNRIYACGGWHESL-----------TEWRVLVEHIYAYDIETNTWSVETKIP 544
            |....|.|.:::.:.::|..||....|           ||         .||.:.:.|::...:|
Frog   474 MNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTE---------VYDPDMDQWTILASMP 529

  Fly   545 APKFYTGVTAMGRTIFFVGGL----DSTESIDRASAETMAYDLDTKEW 588
            ..:...||..:...|..:|||    ..::||       :.:|.:..:|
Frog   530 IGRSGHGVAVLDNQIIVLGGLCYNGHYSDSI-------LTFDPEENKW 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	41/104 (39%)
		PHA03098	46..588	CDD:222983	151/613 (25%)
		BACK	151..249	CDD:285009	17/105 (16%)
		KELCH repeat	344..390	CDD:276965	16/53 (30%)
		KELCH repeat	394..444	CDD:276965	15/49 (31%)
		Kelch	406..458	CDD:128874	16/51 (31%)
		Kelch_1	448..492	CDD:279660	13/58 (22%)
		KELCH repeat	448..492	CDD:276965	13/58 (22%)
		Kelch_1	494..539	CDD:279660	11/55 (20%)
		KELCH repeat	495..539	CDD:276965	11/54 (20%)
klhl15	XP_002935246.1	BTB_POZ_KLHL15	1..137	CDD:349553	50/127 (39%)
		PHA03098	31..590	CDD:222983	151/613 (25%)
		BACK_KLHL15	128..235	CDD:350529	24/134 (18%)
		KELCH repeat	321..365	CDD:276965	16/53 (30%)
		KELCH repeat	369..412	CDD:276965	15/49 (31%)
		KELCH repeat	417..474	CDD:276965	13/56 (23%)
		KELCH repeat	478..529	CDD:276965	11/59 (19%)
		KELCH repeat	532..572	CDD:276965	10/46 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133095at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45632
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.110