DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1812 and Klhl33

DIOPT Version :9

Sequence 1:	NP_608397.1	Gene:	CG1812 / 33049	FlyBaseID:	FBgn0031119	Length:	616	Species:	Drosophila melanogaster
Sequence 2:	XP_002728241.3	Gene:	Klhl33 / 100362676	RGDID:	2324282	Length:	793	Species:	Rattus norvegicus

Alignment Length:	615	Identity:	151/615 - (24%)
Similarity:	245/615 - (39%)	Gaps:	108/615 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PAP--AVTPAATATSAAAKIPVNPVSPEEETLLRGLNKLR-NEEKLT------------------ 48
            |||  .|..||.|..|........:.||      ||.|.| :|:|||
  Rat   171 PAPQDEVLAAAKALGAPRVKIAAQLRPE------GLGKAREDEKKLTQAEELRENLHSIERLYRE 229

  Fly    49 ----DVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKARAMGSIIDYIYT 109
                |:.|..|.:|.:.|||.||..|::|.||... .|.||:..:::|..|.::.:..::.:.||
  Rat   230 GIGCDLELEAEGYRLQVHRVALACGSEFFGAMLLS-GMRESQGTKVSLRTISSQDLRLLVSFAYT 293

  Fly   110 SMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLSERAYRYM 174
            .::...:..:.....||...|....:|.|...|...:....|||:..|.:..|:..:.::|:.|:
  Rat   294 GVVRERWPGLLRAAQAALQYQSSSCLDLCQRALAQSLCPALCLALFPMIEAPGLEKVWKKAHHYL 358

  Fly   175 CAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAE--QDLVRLVCSFAIEQQLNESALGDLLRLI 237
            ..|....|:...|..:.|..|..:|.|: .:.|.|  :......|..|...:..||....|||.:
  Rat   359 LTHLPAVASCPAFPSLPVTCLAELLDSD-ELHVQEEFEAFAAARCWLAANPETQESEAKALLRCV 422

  Fly   238 KWQHISYKSVDELRNMNCSLDKGKQLPL-PTSYYNRIKQEHMGHLLNGVVSLKDQSLPQGPTNMR 301
            ::..:|.:   |||.:..:   |...|| |...|..:.:..:                .|....|
  Rat   423 RFGRMSTR---ELRKVRAA---GLPEPLQPDLLYQLMVEAEV----------------PGQERWR 465

  Fly   302 GMELCLLKIGGFEWNGLTNVIMCFSP-----------------KKMNWYELTAIPHIDQCNFGTA 349
            ..:..|:.|||   :||...:....|                 :.:.|..|..:|...:...|.|
  Rat   466 EPDQALVVIGG---DGLRPDMDRRKPSCKVWWARAFHCGMGLVRTVEWCRLPNLPAPGRFRHGAA 527

  Fly   350 VL-NNKLFIVGGAYDVFLKEYIHPFGFCYCPLR-----NTWMTIAPIQQDRCRFSLNAVGTQHLY 408
            .| ..:|::.||      :::..|.......||     ..|..:||:.|.|..|.| .|....||
  Rat   528 SLTGGELYVCGG------QDFYSPTNTLASTLRWSSSQEDWEEMAPLCQARSFFPL-VVFDGQLY 585

  Fly   409 AVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVH-LANIL 472
            .:||   .||..||   ::||.|:...|||...|:|......||..::.|:||:|||.. ....|
  Rat   586 VLGG---RDNGVAL---NSVETYNPELNVWRPAPALPAPCFAHAAAILEDRLYVSGGCSGTGQYL 644

  Fly   473 ASMWVFDTKTEVWQELAS-MPTPCCDHVLVAVDNRIYACGGWHES--LTEWRVLVEHIYAYDIET 534
            .|:..:|.|.:....|.| |......||:.|:..::|..||..::  |..:.       ||:.:|
  Rat   645 DSLIHYDPKLKKPGTLLSPMGVARASHVMAALGGKLYVAGGIGDTGDLLSFE-------AYEPKT 702

  Fly   535 NTWSVETKIPAPKFYTGVTAMGRTIFFVGG 564
            ::|:....:|:|........:...:..:||
  Rat   703 DSWTHLASLPSPHVGAAGAVLQGELLVLGG 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1812	NP_608397.1	BTB	38..142	CDD:279045	32/126 (25%)
		PHA03098	46..588	CDD:222983	136/571 (24%)
		BACK	151..249	CDD:285009	24/99 (24%)
		KELCH repeat	344..390	CDD:276965	11/51 (22%)
		KELCH repeat	394..444	CDD:276965	19/49 (39%)
		Kelch	406..458	CDD:128874	18/51 (35%)
		Kelch_1	448..492	CDD:279660	14/45 (31%)
		KELCH repeat	448..492	CDD:276965	14/45 (31%)
		Kelch_1	494..539	CDD:279660	11/46 (24%)
		KELCH repeat	495..539	CDD:276965	11/45 (24%)
Klhl33	XP_002728241.3	BTB	234..330	CDD:197585	26/96 (27%)
		BACK	335..435	CDD:197943	27/103 (26%)
		muta_rot_YjhT	513..765	CDD:274641	65/240 (27%)
		KELCH repeat	521..569	CDD:276965	12/53 (23%)
		Kelch	534..582	CDD:128874	14/54 (26%)
		KELCH repeat	572..615	CDD:276965	19/49 (39%)
		Kelch	583..629	CDD:128874	18/51 (35%)
		Kelch_1	618..656	CDD:279660	12/37 (32%)
		KELCH repeat	619..665	CDD:276965	14/45 (31%)
		Kelch_1	667..712	CDD:279660	11/51 (22%)
		KELCH repeat	668..713	CDD:276965	11/51 (22%)
		KELCH repeat	715..761	CDD:276965	2/18 (11%)
		BTB	100..190	CDD:295341	8/18 (44%)
		BTB	224..326	CDD:279045	25/102 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45632
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.100