DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and ARHGAP32

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_001364953.1	Gene:	ARHGAP32 / 9743	HGNCID:	17399	Length:	2101	Species:	Homo sapiens

Alignment Length:	1499	Identity:	292/1499 - (19%)
Similarity:	514/1499 - (34%)	Gaps:	423/1499 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   927 ETEIEIK-SSCINGKRMSEYRSWRQVKLEIKGDLLRIYSGRHAKSEHNVIELDIRNF-----KFF 985
            |:|:.|: :.|...:|..::|              ::.|..|::.:..|.||. ||.     ..:
Human    19 ESEVIIQVTDCEEEEREEKFR--------------KMKSSVHSEEDDFVPELH-RNVHPRERPDW 68

  Fly   986 DESMDKKKYLIRMQSKPS-PSGAHLASLGNELNLDEGHDKLLTSSGSSSANE----PAANAASAL 1045
            :|::..   :.|....|. |....|.:.|:..::...|.|..|:.|....:.    |........
Human    69 EETLSA---MARGADVPEIPGDLTLKTCGSTASMKVKHVKKSTTPGLMGCDNIHRLPFTKGHFPK 130

  Fly  1046 TASTSSSTCSSGPYTEILFKT-------------KSSNEMKRLFGLLQ-------WKDSLNYDD- 1089
            .|.     |:...|..:.|.:             |:..|.|.|..|:|       |....:|:|
Human   131 MAE-----CAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDF 190

  Fly  1090 ---NEH---------------QPQGKQLAEPQKTVAS--ASYLDDVQGGASAADSSPLSSHSG-- 1132
               ::|               .|:...|.:..::|..  .:||            |.||:.:|
Human   191 RVLDKHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYL------------SRLSAIAGNK 243

  Fly  1133 ---GIA------DASGSH---------HVSALPAAAAIVAATS-----------DSISPVMKARK 1168
               |.|      |..|:|         :..|:.||..|...|:           |.:|.:....|
Human   244 INCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPK 308

  Fly  1169 SSS----HKH------------------IPDKDLGS-PK---SKNWKDLLFRRGGSGSGGVSHHD 1207
            ..|    .||                  :|.....| ||   .|:.|.:.|.|....|
Human   309 VLSTWWRGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKS------- 366

  Fly  1208 LASPSACAAKQIGSIGVPLRSCPMSK--VNA--YVPHLVEVCTNIVETKGLGVVGIYRIPGNKAA 1268
              .|:....||.|.:...:..|.:.:  :|:  .||.:::.||..:|..|: |.||||:.|..:.
Human   367 --RPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDGIYRLSGVASN 428

  Fly  1269 ISELSELVNTKDFQFES-----CASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYINFIEA--- 1325
            |..|..       :|:|     ...:...:|::.|.||.||:.|.||:.|:....|..|.:|
Human   429 IQRLRH-------EFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSA 486

  Fly  1326 --DKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTP 1388
              |:    ||::.:.::::.||...|.|::.|:|||..::..|.:..|..|||||::.|:::|:.
Human   487 ATDE----ERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSK 547

  Fly  1389 NDTLET-------AVKDMKHQCRIVELLVTQYDYFFEGG------------SLPDIAEVSG-GTA 1433
            .  :|:       |..:::.|..:||.::...|..|.|.            |.|....||. .|.
Human   548 Q--IESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLLVSSPSTK 610

  Fly  1434 AVSAAQPQQQTQEDQTSMLLHNLSKIERITERETTRTSRF-----------MPQLRRKTH----- 1482
            .::..:.|.:||....|.::.....|| :.|.......:|           .||.:.|..
Human   611 LLTLEEAQARTQAQVNSPIVTENKYIE-VGEGPAALQGKFHTIIEFPLERKRPQNKMKKSPVGSW 674

  Fly  1483 ------GKRSAVN--------SDTYSGESVLVSGSSSNTTTTTTTTTHTTSS------------- 1520
                  ||.|:|:        |:....:::.:.|..:..|..:..:..:.:|
Human   675 RSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAVDGDSKLFRP 739

  Fly  1521 ---TSSSNTITTTISTTTIQQR-----------RAQRK-------AVQSICDQALILLLPTPVSS 1564
               .|||:.::.:.:...:..|           .::.:       |:.|......:.|.|..:..
Human   740 RRPRSSSDALSASFNGEMLGNRCNSYDNLPHDNESEEEGGLLHIPALMSPHSAEDVDLSPPDIGV 804

  Fly  1565 VSLPFQSLDYAKASASASASASSTASTSSSSTLHSGGKASASSSSSSTTKFSSSSSSACSTTAVA 1629
            .||.|..:.:..:...|.:....:.::...|..:|..|.||:...:.|      .||.|.|....
Human   805 ASLDFDPMSFQCSPPKAESECLESGASFLDSPGYSKDKPSANKKDAET------GSSQCQTPGST 863

  Fly  1630 ISSSISATSSKLLSANFKKRSTGGFLGSRSSHQTRKASLDEKDSGQSSGSLGHSLGVGINLAKEQ 1694
            .||...:...:.||..|...     |.......::.:|..||.....|..:|.      .|:|..
Human   864 ASSEPVSPLQEKLSPFFTLD-----LSPTEDKSSKPSSFTEKVVYAFSPKIGR------KLSKSP 917

  Fly  1695 QRS-SVDISILLTDDDSSSRLSDT-GSMSLTTITDTLDSKLRNLRSGSESNDENGSP-EFPKNR- 1755
            ..| |..||:.|     ..|:|:. |::|.||..:...|...  :...|.:..|.|| :..|.:
Human   918 SMSISEPISVTL-----PPRVSEVIGTVSNTTAQNASSSTWD--KCVEERDATNRSPTQIVKMKT 975

  Fly  1756 RHTLGQPLHMHSENIPYADESPERLFHQFCNPLETAPLSLHLSRSCTATNTIGGDEKPSKQSGGV 1820
            ..|:.|..: .||..|....:.|.:         ..|.....|.|.:.:..:...:   .|:|.|
Human   976 NETVAQEAY-ESEVQPLDQVAAEEV---------ELPGKEDQSVSSSQSKAVASGQ---TQTGAV 1027

  Fly  1821 APLPPSLLKAAHKLQHSATVPIHQGSSTAPTSGAATPVGTPTGSGGAGAIPSRSSSSSVTTLTKS 1885
            ...||           ..:||:...|...|         .|.....|..:....:.|:....|:|
Human  1028 THDPP-----------QDSVPVSSVSLIPP---------PPPPKNVARMLALALAESAQQASTQS 1072

  Fly  1886 I------QPRFSNYLSYERGNAAAGGAERVVGSAGGAASDDDSEGSTTSDPKEKLLLGERPSPSF 1944
            :      |..::||     |:.|....|..:.|:..|.:.|.:...|           :||:..|
Human  1073 LKRPGTSQAGYTNY-----GDIAVATTEDNLSSSYSAVALDKAYFQT-----------DRPAEQF 1121

  Fly  1945 FIERYNKKRRDHRLFRSAS------FNCRNYSTRHITAQTSGGV--AAGVSGGVAGAVAVGVACC 2001
            .::.......||.|..:.:      .|......:|.....:|..  .|.:||...
Human  1122 HLQNNAPGNCDHPLPETTATGDPTHSNTTESGEQHHQVDLTGNQPHQAYLSGDPE---------- 1176

  Fly  2002 QALSTTGLTKDEKTDMNLTKKRQIQNK----------QNRSIKRRHTVGGPHDYSASNGGCSNHS 2056
            :|..|:.....||:|.:::.......|          |::|..|.::...|..|..
Human  1177 KARITSVPLDSEKSDDHVSFPEDQSGKNSMPTVSFLDQDQSPPRFYSGDQPPSYLG--------- 1232

  Fly  2057 HGHDLAAINYNHHNRHHQQQLLKLGSATSGG-------GGSGAAAAETTTTT---TTTTTVLRRL 2111
                 |:::..||......:     |.|...       ..||:....|:|.|   .|||....::
Human  1233 -----ASVDKLHHPLEFADK-----SPTPPNLPSDKIYPPSGSPEENTSTATMTYMTTTPATAQM 1287

  Fly  2112 GTGQA----GAEASVALPASSSGSSSNNNNSPQSDGSNGNGGGVAGVASNAPP------TGVGVG 2166
            .|.:|    ..:.:.|..|:::...::..|.|.....:..       ::..||      ....:|
Human  1288 STKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPPPSQR-------SAEQPPVVGQVQAATNIG 1345

  Fly  2167 GNNS 2170
            .|||
Human  1346 LNNS 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	57/216 (26%)
ARHGAP32	NP_001364953.1	PX_RICS	141..255	CDD:132831	22/125 (18%)
		SH3_ARHGAP32_33	277..330	CDD:212769	10/52 (19%)
		RhoGAP_CdGAP	382..576	CDD:239849	56/207 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	832..872		12/45 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..1052		28/145 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1117..1157		6/39 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1183..1271		16/106 (15%)
		Interaction with GAB2. /evidence=ECO:0000269\|PubMed:12819203	1405..1725
		Interaction with FYN. /evidence=ECO:0000269\|PubMed:12788081	1699..2101
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1812..1910
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940