DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and ARHGAP12

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_060757.4	Gene:	ARHGAP12 / 94134	HGNCID:	16348	Length:	846	Species:	Homo sapiens

Alignment Length:	886	Identity:	190/886 - (21%)
Similarity:	318/886 - (35%)	Gaps:	283/886 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 KATLANATIDPV------PVGSSKFVT---LPDKPDKGSSVATLADIAESSAAAIVDSASGSGNV 759
            |.....|.:.||      |..|:|.:.   |....:..:.:..|:...:.|:     |..|:| :
Human    70 KEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPSS-----SVQGTG-L 128

  Fly   760 VRRYKPLSSSSFDEGKPMRRISYLRATNNETDFNAEAAAGGDAAATGASGPASASAASSAPGPTP 824
            :|........|:::|:.: .:| |..|:|...||.:                |.|...|:...|.
Human   129 IRDANQNFGPSYNQGQTV-NLS-LDLTHNNGKFNND----------------SHSPKVSSQNRTR 175

  Fly   825 SSAPAPAPAPAPLPISIPIPVAAVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFI--ETPNGLED 887
            |....|.|              ..::.:||....|:..|       ..|.|.|.|  ::.:|.|.
Human   176 SFGHFPGP--------------EFLDVEKTSFSQEQSCD-------SAGEGSERIHQDSESGDEL 219

  Fly   888 VRLSAHGSRRASMSSDMRSSIHIDA---------------------ELNGKYVPNELEAFETEIE 931
            ...|....|..:..:..|....:.|                     ::||::        ||..:
Human   220 SSSSTEQIRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAIQINGEW--------ETHKD 276

  Fly   932 IKSSCINGKRMSEYRSW------RQVKLEIKGD--------LL----RIYSGRHAKSEHNV---- 974
            ....|....|.::.|:|      |...:. |||        ||    ..||..:::|:...
Human   277 SSGRCYYYNRGTQERTWKPPRWTRDASIS-KGDFQNPGDQELLSSEENYYSTSYSQSDSQCGSPP 340

  Fly   975 ----IELDIRNFKFFDESMDKKKYLIRMQSKPSPSGAHLASLGNELNLDEGHDKLLTSSGSSSAN 1035
                .|||.|....:......:|:|..:.                   |:|.....::.||.|..
Human   341 RGWSEELDERGHTLYTSDYTNEKWLKHVD-------------------DQGRQYYYSADGSRSEW 386

  Fly  1036 E-PAANAAS--------------------ALT---------------ASTSSSTC----SSGPYT 1060
            | |..||:|                    .||               :.|:|..|    .|.|.:
Human   387 ELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSS 451

  Fly  1061 EILFKTKSSNEMKRLFGLL------------------QWK----DSLNYDDNEHQPQ---GKQLA 1100
            .....|.||.:.:..:|||                  .|.    .||.:...:....   |...:
Human   452 PKHQDTASSPKDQEKYGLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQS 516

  Fly  1101 EPQKTVASASYLDDVQGGASAADSSPLSSHSGGIADASGSHHVSAL---PAAAAIVAATSDS-IS 1161
            :|:.||       |::|......|.          |.|...:|..|   .....::.:.:|: |:
Human   517 KPEFTV-------DLKGATIEMASK----------DKSSKKNVFELKTRQGTELLIQSDNDTVIN 564

  Fly  1162 PVMKARKSSSH---------------------KHIPDKDLGSPK------------------SKN 1187
            ...|...|:.:                     ||..:|:...||                  .||
Human   565 DWFKVLSSTINNQAVETDEGIEEEIPDSPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKN 629

  Fly  1188 WKDLLFRRGGSGSGGVSHHDLASPSACAAKQIGSI-----GVPLRS-CPMSKVNAYVPHLVEVCT 1246
            .|..|.||               |:..|.::.|.|     |..|.: |  .:.|..||..|::|.
Human   630 LKKFLTRR---------------PTLQAVREKGYIKDQVFGSNLANLC--QRENGTVPKFVKLCI 677

  Fly  1247 NIVETKGLGVVGIYRIPGNKAAISELSELVNTKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPD 1311
            ..||..||.:.||||:.||.|.|.:|...|| .|.:.:  .:|.:|||::|::..||:|.|.||:
Human   678 EHVEEHGLDIDGIYRVSGNLAVIQKLRFAVN-HDEKLD--LNDSKWEDIHVITGALKMFFRELPE 739

  Fly  1312 ALMPASYYINFIEADKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNL 1376
            .|...:::.:|:.|.|:...:|:..:::::..||:...:||:.|.|||.||..|.:.|||..:::
Human   740 PLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSI 804

  Fly  1377 AIIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQYDYFF 1417
            ||:|||::::...:|...||..: :|.:||||::.:....|
Human   805 AIVFGPTLLKPEKETGNIAVHTV-YQNQIVELILLELSSIF 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	68/201 (34%)
ARHGAP12	NP_060757.4	SH3-WW_linker	71..266	CDD:293224	42/239 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..241		24/125 (19%)
		WW	268..298	CDD:238122	8/37 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..316		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..466		8/37 (22%)
		PH_ARHGAP9-like	465..576	CDD:270053	21/127 (17%)
		PH	479..574	CDD:278594	18/111 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	580..629		5/48 (10%)
		RhoGAP_ARHGAP27_15_12_9	654..839	CDD:239868	67/190 (35%)
		SH3_ARHGAP12	15..74	CDD:213003	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010