DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and BEM3

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_015210.1	Gene:	BEM3 / 855988	SGDID:	S000006036	Length:	1128	Species:	Saccharomyces cerevisiae

Alignment Length:	1373	Identity:	267/1373 - (19%)
Similarity:	447/1373 - (32%)	Gaps:	427/1373 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 QVKAMETIFIKEVQANGPAH----YANLQTGDRVLMVNNQPIAGIAYSTIVSMIKQTPAVLTLHV 204
            :::::|.: |..:|.|..|.    ...:|...|...||:|..                      |
Yeast    69 EIESLEKV-IDMLQKNREASLEVVLEQVQNDSRDSYVNDQSF----------------------V 110

  Fly   205 VPKECDVLQMHYTSIAHTPESNRLTMSTHSPSLLANG------SHKTTFPAAAAVAAPPHQHQQQ 263
            :|......:.|..|:       .|.:.|.||.|....      |...|.|.....:......:..
Yeast   111 LPPRSAERKAHIKSL-------NLPIPTLSPPLQQGSDVALETSVTPTVPQIGVTSNTSISRKHL 168

  Fly   264 QQQLISYPAVAAVTTSTPAGSPQSQSQSQSHSHPNTHHAPSLHGGSRSGSITSTASGGITVLSQ- 327
            |..:::....|..:.|:|      :..::|.|.|...|:..|  .|.:.|:|.|.| .||:.|.
Yeast   169 QNMILNDEIEANSSFSSP------KIINRSVSSPTKIHSEQL--ASPAASVTYTTS-RITIKSPN 224

  Fly   328 --PFYPQQQQQQQQQQQHRHPALTG--------GSSSIDFGDMAHGLRQHQQQQQHLYQQQQQHH 382
              ...|.|::.:..|..:|..|:..        .|:|.:..::...            :.||..:
Yeast   225 KGSKSPLQERLRSPQNPNRMTAVINNHLHSPLKASTSNNLDELTES------------KSQQLTN 277

  Fly   383 QFMRANQPPNLTVLSASSATNTPTPTARQPKSATSHNQALYAVGAGPSSAAGSGSGSLSGGSENS 447
            ..::.|.....::.|::..|.|||..|:.|.|       |..|..|.:.|.|....|    .|..
Yeast   278 DAIQKNDRVYSSITSSAYTTGTPTSAAKSPSS-------LLEVKEGENKALGFSPAS----KEKL 331

  Fly   448 DLMIRLRESIKQKEEFLKSPVPASMSSASSINGNQAQSSSPAQQQHLQQHQQHFFPSHTPPGGVQ 512
            |...:|.:|...:|:.:.:.....:|..|:||.:.....:|..          || |.|..|.::
Yeast   332 DDFTQLLDSSFGEEDLVNTDSKDPLSIKSTINESLPPPPAPPT----------FF-SPTSSGNIK 385

  Fly   513 VVVPPPRSRH---QVMLKQQQQQQQQHQQHHVLGYDMYHSGGKLVQRSSTAPGSVCHQHQQQQQH 574
              ...|.|.|   .|:|.::..
Yeast   386 --NSTPLSSHLASPVILNKKDD------------------------------------------- 405

  Fly   575 HLYHQQQHQQLQQTQHRQVMINNNAKYAKDLDYFETLQETGVTNKVFERKLVSHMSKGFDPFKPL 639
                                 |..|:.||:|.                              ||:
Yeast   406 ---------------------NFGAQSAKNLK------------------------------KPV 419

  Fly   640 SINTSALESSASTSSTSATTTVKKQSVLYESLQQHPLAKYHQTQQQTTTTTTVDGQTSSRMELHK 704
                  |.||....||..:||.:.     .||..:|..:....|:|.       |:|:|   :|.
Yeast   420 ------LTSSLPNLSTKLSTTSQN-----ASLPPNPPVESSSKQKQL-------GETAS---IHS 463

  Fly   705 ATLANATIDPVPVGSSKFVTLPDKPDKGSSVATLADIAESSAAAIVDSASGSGNVVRRYKPLSSS 769
            ....| |....|.||.|.:..|    ..|||:|:..:|:|..:.|               ||...
Yeast   464 TNTLN-TFSSTPQGSLKTLRRP----HASSVSTVKSVAQSLKSDI---------------PLFVQ 508

  Fly   770 SFDEGKPMRRISYLRATNNETDFNAEAAAGGDAAATGASGPASASAASSAPGPTPSSAPAPAPAP 834
            ..|.|.....:......:||.|.:...     |.....||......:.|............:..|
Yeast   509 PEDFGTIQIEVLSTLYRDNEDDLSILI-----AIIDRKSGKEMFKFSKSIHKVRELDVYMKSHVP 568

  Fly   835 -APLPISIPIPVAAVVEPQKT---KSLVEEHPDPTYDVIGGTGGGHEFIETPNGLEDVRLSAHGS 895
             .|||......:...:.|.|.   |:::.::....:.|          .|.|..: .::::...|
Yeast   569 DLPLPTLPDRQLFQTLSPTKVDTRKNILNQYYTSIFSV----------PEFPKNV-GLKIAQFIS 622

  Fly   896 RRASMSSDMRSSIHIDAELNGKYVPNELEAFETEIEIKSSCI---NGKRMSEYRSWRQVKLEIKG 957
            ....|:..|...                       .:|...:   ..|.::...:||.....::.
Yeast   623 TDTVMTPPMMDD-----------------------NVKDGSLLLRRPKTLTGNSTWRVRYGILRD 664

  Fly   958 DLLRIYSGRH----AKSEHNVIEL---------DIRNFKFFDE------SMDKKKYLIRMQSKPS 1003
            |:|:::....    .|...:.|||         ..||.....|      |...|.|:....||.
Yeast   665 DVLQLFDKNQLTETIKLRQSSIELIPNLPEDRFGTRNGFLITEHKKSGLSTSTKYYICTETSKE- 728

  Fly  1004 PSGAHLASLGNELNLDEGHDKL-----LTSSGSSSANEPAANAASALTASTSSSTCSSGPYTEIL 1063
                      .||.|....|.:     |:.|.|.:||:  .::||.|:|.|..|
Yeast   729 ----------RELWLSAFSDYIDPSQSLSLSSSRNAND--TDSASHLSAGTHHS----------- 770

  Fly  1064 FKTKSSNEMKRLFGLLQWKDSLNY--DDNEHQPQGKQLAEPQKTVASASYLDDVQGGASAADSSP 1126
               |..|      ..:...|:.:|  |..:.......::.....:|:          :...||:|
Yeast   771 ---KFGN------ATISATDTPSYVTDLTQEYNNNNNISNSSNNIAN----------SDGIDSNP 816

  Fly  1127 LSSHSGGIADASGSHH---------VSAL--------PAAAAI---VAATSDSISPVMKARKSSS 1171
             ||||..:|.:||:..         :.:|        ||:|..   :..::||.||..
Yeast   817 -SSHSNFLASSSGNAEEEKDSRRAKMRSLFPFKKLTGPASAMNHIGITISNDSDSPTS------- 873

  Fly  1172 HKHIPDKDLGSPKSKNWKDLLFRRGGSGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSKVNA 1236
                ||..:.||..|    |:.....|.|.       ..|....|....|:...||.......|.
Yeast   874 ----PDSIIKSPSKK----LMEVSSSSNSS-------TGPHVSTAIFGSSLETCLRLSSHKYQNV 923

  Fly  1237 Y-VPHLVEVCTN-IVETKGLGVVGIYRIPGNKAAISELSELVNTKDFQFESC-------ASDDR- 1291
            | :|.:|..|.. :.:.:|:...||:|:.|:...|..|.|..: |::..:.|       |.||.
Yeast   924 YDLPSVVYRCLEYLYKNRGIQEEGIFRLSGSSTVIKTLQERFD-KEYDVDLCRYNESIEAKDDEA 987

  Fly  1292 ----WEDVNVVSSLLKLFIRSLPDALMPASYYINF---IEADKKFGLERIVLLREIVES--LPRH 1347
                :..||.||.||||::|.||..|.....:::|   ::.:....::..:..:|::||  :|..
Yeast   988 SPSLYIGVNTVSGLLKLYLRKLPHLLFGDEQFLSFKRVVDENHNNPVQISLGFKELIESGLVPHA 1052

  Fly  1348 PYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQ 1412
            ....|..|...|.|::.|...|:|..:||.|:|.|        ||...:.       :::..:|.
Yeast  1053 NLSLMYALFELLVRINENSKFNKMNLRNLCIVFSP--------TLNIPIS-------MLQPFITD 1102

  Fly  1413 YDYFFEGG 1420
            :...|:||
Yeast  1103 FACIFQGG 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492	9/57 (16%)
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	53/214 (25%)
BEM3	NP_015210.1	PX	520..622	CDD:214610	17/117 (15%)
		PH_Bem3	633..741	CDD:270096	22/141 (16%)
		RhoGAP	904..1110	CDD:413382	54/221 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23176
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100